Description of the medicine: Deoxyribonuclease (Desoxyribonucleasum)

Deoxyribonuclease (Desoxyribonucleasum).

Deoxyribonuclease is an enzyme contained in the pancreas and intestinal mucosa; Protein of albumin type. Hydrolyses (depolymerizes) DNA to form deoxyribonucleotides.

For medical use are obtained from the pancreas of cattle. It is a lyophilized white powder, soluble in water and isotonic sodium chloride solution; PH 0.1% aqueous solution 3, 0 - 5, 5. Aqueous solutions (and powder) are inactivated when heated above +55 ° C.

The activity is determined by the formation of acid-soluble products released by the preparation under certain conditions from DNA; It is expressed in units of activity (EA). In 1 mg of the drug should contain at least 1700 EA.

Preparations that are similar in effect to deoxyribonuclease are produced abroad under the names "Rancreatic dornase", "Dornavac", etc.

Deoxyribonuclease has the ability to delay the development of viruses of herpes, adenoviruses and other viruses containing DNA. The effect is associated with the depolymerization of DNA to mono- and oligonucleotides by cleavage of internucleotide linkages. By suppressing the synthesis of viral DNA, deoxyribonuclease does not damage the DNA of the macroorganism cells.

Deoxyribonuclease also causes depolymerization and liquefaction of pus.

Applied with herpetic keratitis and keratouveitis, adenoviral conjunctivitis and keratitis, lung abscesses, acute catarrhal inflammation of the upper respiratory tract adenovirus nature; To reduce the viscosity and improve the evacuation of sputum and pus with bronchoectatic disease, lung abscesses, atelectasis, pneumonia; In the preoperative and postoperative periods in patients with purulent lung diseases, pulmonary tuberculosis.

For external use, use deoxyribonuclease as a 0.2% solution (2 mg of the drug in 1 ml) on isotonic sodium chloride solution. The solutions are prepared daily; The shelf life of the solution is 12 hours.

With herpetic keratitis and keratouveitis injected under the conjunctiva of the affected eye daily with 0.5 ml of sterile solution of deoxyribonuclease for 2 to 4 weeks. In addition, instilled in the eye 2 to 3 drops of 0.2% solution 3 - 4 times a day. For the prevention of relapse continue to inject the drug for 6 to 10 days after persistent clinical improvement.

For the treatment of adenoviral keratoconjunctivitis, 1 to 2 drops of a 0.05% solution of distilled water are injected into the conjunctival cavity every 1-5 to 2 hours during the day.

In acute catarrhal inflammation of the upper respiratory tract of adenoviral nature, the solution is buried in the nose or injected in the form of an aerosol; Inhalation for 10 to 15 minutes is performed 2 to 3 times a day for 2 to 5 days. For each inhalation - 3 ml of 0.2% solution.

In the case of suppuration in the lungs, the solution is injected into the respiratory tract in the form of an aerosol at a rate of 1 ml of the solution for 10-15 minutes.