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Description of the medicine: Lizoamidase (Lysoamidasa)

LYSOAMIDASE. (Lysoamidasa).

Proteolytic enzyme produced by a bacterial culture from the family Pseudomonodaceae.

Lyophilized powder or porous mass of gray with a brown tint. Slightly soluble in water.

The activity of the drug is expressed in proteolytic units (PE). 1 mg of the drug contains at least 0.7 PE.

Lizoamidase also has a bacteriolytic effect. Bacteriolytic (lytic) activity is expressed in LE.

Lizoamidase as a proteolytic drug helps to cleanse wounds from purulent-necrotic masses, accelerate the formation of fresh granulations and improve the conditions for wound healing.

As a bacteriolytic agent, the drug is able to destroy the cell walls of gram-positive bacteria: staphylococci, streptococci, corynebacteria, as well as meningococci, gonococci, etc.

It is used in adults for the treatment of purulent wounds and burns in order to cleanse them from purulent-necrotic masses, accelerate the creation of fresh granulations and healing. It is prescribed for purulent-inflammatory skin diseases (folliculitis, furunculosis and other forms of pyoderma), for mastitis and endometritis, periodontal disease, stomatitis, pulpitis, periodontitis, osteomyelitis, diseases of the oral mucosa, etc., as well as for the treatment of angina and debridement .

Apply topically in the form of solutions in 0.01 M sodium phosphate buffer (pH 8, 0) at concentrations of 5 PE (50 LE) in 1 ml; 10 PE (100 LE) in 1 ml; 25 PE (250 LE) in 1 ml.

In the presence of purulent wounds, purulent-inflammatory skin diseases, mastitis and burns, lysoamidase applications are used. The wound is pre-treated, then gauze wipes are abundantly moistened with a solution of lysoamidase and applied to the wound surface under a moisture-proof dressing. The dressing is changed 1 to 2 times a day as it dries. Depending on the type and size of the affected surface. the daily dose is 250 - 500 PE (2500 - 5000 LE) and can be increased if necessary. The course of treatment of purulent wounds is 7-10 days, burns are 6-7 days. When plugging deep wounds with napkins or foam sponges, abundantly moistened with lysoamidase, they loosely fill the wound passage. Using an irrigator, wipes or sponges are moistened 4 to 5 times a day. Napkins are changed every 3 to 4 days. The daily dose is 100 - 150 PE (1000 - 1500 LE).

With endometritis, irrigation with lysoamidase is carried out 1 to 2 times a day. The daily dose is 150 - 400 PE (1500 - 4000 LE). The course of treatment is from 5 to 7 days.

In dental practice, apply and rinse the mouth with the drug. Rinses are performed 2 times a day for 10 minutes, using 50-60 ml (100-300 PE; 1000-3000 LE) of solution. The course of treatment is 5 to 7 days. Before application, the mucous membrane is treated with sodium phosphate buffer solution. Applications are carried out within 30-60 minutes; during the procedure, tampons are changed 4 to 5 times.