Medication Description: Lysoamidase (Lysoamidasa)
A proteolytic enzyme produced by a bacterial culture from the Pseudomonodaceae family.
Lyophilized powder or porous mass of gray with a brown tint color. Few soluble in water.
The activity of the drug is expressed in proteolytic units (PE). 1 mg of the drug contains at least 0.7 PE.
Lidoamidase also has a bacteriolytic effect. Bacteriolytic (lytic) activity is expressed in LU.
Lizoamidaza as a proteolytic drug helps cleanse wounds from purulent-necrotic masses, accelerate the formation of fresh granulations and improve the conditions for wound healing.
As a bacteriolytic agent, the drug is able to destroy the cell walls of gram-positive bacteria: staphylococci, streptococci, corynebacteria, as well as meningococci, gonococci, etc.
Applied in adults for the treatment of purulent wounds and burns in order to clean them from purulent-necrotic masses, accelerate the creation of fresh granulations and healing. It is prescribed for purulent-inflammatory skin diseases (folliculitis, furunculosis and other forms of pyoderma), for mastitis and endometritis, periodontal disease, stomatitis, pulpitis, periodontitis, osteomyelitis, diseases of the oral mucosa, etc., as well as for treating angina and sanation, sanitization and sanation, and for sanitization of the oral mucosa, etc. .
Applied topically in the form of solutions in 0.01 M sodium phosphate buffer (pH 8, 0) in concentrations of 5 PE (50 LE) in 1 ml; 10 PE (100 LE) in 1 ml; 25 PE (250 LE) in 1 ml.
In the presence of purulent wounds, inflammatory diseases of the skin, mastitis and burns, apply the application of isoamidase. The wound is pretreated, then gauze is watered abundantly with a solution of isoamidase and gauze napkins are applied to the wound surface under a moisture-proof bandage. The dressing as they dry is changed 1 - 2 times a day. Depending on the type and size of the affected surface. daily dose is 250 - 500 PE (2500 - 5000 LU) and, if necessary, may be increased. The course of treatment of purulent wounds 7 - 10 days, burns 6 - 7 days. When tamping deep wounds with napkins or foam sponges, abundantly moistened with lysoamidase, loosely fill the wound course. With the help of an irrigator, wipes or sponges are moistened 4-5 times a day. Change napkins every 3 to 4 days. The daily dose is 100 - 150 PE (1000 - 1500 LE).
When endometritis spend irrigation with isoamidase 1-2 times a day. The daily dose is 150 - 400 PE (1500 - 4000 LE). The course of treatment from 5 to 7 days.
In the dental practice, applications and rinsing of the oral cavity with the preparation are used. Rinse produce 2 times a day for 10 minutes, using 50 - 60 ml (100 - 300 PE; 1000 - 3000 LE) solution. The course of treatment is 5-7 days. Before application, the mucous membrane is treated with sodium phosphate buffer solution. Applications are carried out for 30 - 60 minutes; during the procedure, tampons are changed 4 - 5 times.