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Description medications: Lidaza (Lydazum)

Lydasum (Lydazum).

The preparation containing the enzyme hyaluronidase.

Similar products are produced abroad under the title: Alidase, Hyalase, Hyalidase, Hyaluronidasum, Hyasa, Hyason, Hylase, Invasinum, Spredine, Widase and others.

Light yellow or golden-yellowish porous mass. Easily soluble in water.

Hyaluronidase - an enzyme-specific substrate which is hyaluronic acid. The latter is a mucopolysaccharide composed of acetylglucosamine and glucuronic acid. Hyaluronic acid has a high viscosity; its biological importance mainly lies in the fact that it is a cementing substance of connective tissue.

Hyaluronidase or "propagation factor", causes the decomposition of hyaluronic acid, glucosamine to glucuronic acid and thereby reduces its viscosity. Hyaluronidase causes an increase in tissue permeability and facilitates the movement of fluids in the interstices spaces.

Hyaluronidase is found in various body tissues. The system of relations "hyaluronic acid - hyaluronidase" largely regulated tissue permeability. Anti-inflammatory effect of various drugs (salicylates, derivatives of pyrazolone, ACTH, glucocorticoids, steroids, etc.), Partly due to their ability to reduce the activity of hyaluronidase. Conversely, the effects of some substances that increase the permeability (for example, bee and snake venom), due in part to the presence of hyaluronidase.

Action gialurotsidazy is reversible. By reducing its viscosity hyaluronic acid concentration is restored. Thus, hyaluronidase can be used to temporarily reduce the viscosity of hyaluronic acid.

Preparations containing hyaluronidase (lidasa and ronidaza) is obtained from testes of cattle.

Lidaza is specially purified preparation suitable for parenteral (subcutaneous, intramuscular) and inhalative application.

The freeze-dried powder or porous mass or a porous mass of compacted into a tablet, a light color with beige shade. Easily soluble in water.

Drug activity is expressed in conventional units (CU).

Available in bottles, sealed with rubber stoppers and aluminum caps containing 64 CU sterile substance.

For injection, the contents of the vial is dissolved in 1 ml of isotonic sodium chloride solution, or 1 ml of 0.5% novocaine solution for inhalation - in 5 ml of isotonic sodium chloride solution.

The main indications for use are lidazy joint contractures, burns, and scars after operations, ankylosing spondylitis, hematoma and al. Lidazy solution (1 ml) was added in these cases the vicinity of the lesion under the skin or scar-modified tissue. Injections are made daily or every other day; treatment course consists of 6 - 10 - 15 or more injections.