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Medication Description: Lydazum

LIDAZA (Lydazum).

A drug containing the enzyme hyaluronidase.

Similar drugs are produced abroad under the names: Alidase, Hyalase, Hyalidase, Hyaluronidasum, Hyasa, Hyason, Hylase, Invasinum, Spredine, Widase, etc.

Weak or golden yellow porous mass. Easily soluble in water.

Hyaluronidase is an enzyme whose specific substrate is hyaluronic acid. The latter is a mucopolysaccharide, which consists of acetylglucosamine and glucuronic acid. Hyaluronic acid has a high viscosity; its biological significance lies mainly in the fact that it is a cementing substance of connective tissue.

Hyaluronidase, or "proliferation factor", causes the breakdown of hyaluronic acid to glucosamine glucuronic acid and thereby reduces its viscosity. Hyaluronidase causes an increase in tissue permeability and facilitates the movement of fluids in interstitial spaces.

Hyaluronidase is found in various tissues of the body. The ratio of the system "hyaluronic acid - hyaluronidase" largely regulates tissue permeability. The anti-inflammatory effect of various drugs (salicylates, pyrazolone derivatives, ACTH, glucocorticoids, steroids, etc.) is partly due to their ability to reduce the activity of hyaluronidase. On the contrary, the effect of certain substances that increase permeability (for example, bee and snake venom) is partly due to the presence of hyaluronidase in them.

The effect of hyalurocidase is reversible. With a decrease in its concentration, the viscosity of hyaluronic acid is restored. Thus, hyaluronidase can be used to temporarily reduce the viscosity of hyaluronic acid.

Preparations containing hyaluronidase (lidaza and ronidaza), obtained from the testes of cattle.

Lidaza is a specially purified drug suitable for parenteral (subcutaneous, intramuscular) and inhalation use.

Lyophilized powder or porous mass, or porous mass, compacted into a pill, light color with a beige tinge. Easily soluble in water.

The activity of the drug is expressed in arbitrary units (UE).

Available in bottles, sealed with rubber stoppers with aluminum caps, containing 64 UE of sterile substance.

For injection, the contents of the vial are dissolved in 1 ml of isotonic sodium chloride solution or in 1 ml of 0.5% novocaine solution, for inhalations - in 5 ml of isotonic sodium chloride solution.

The main indications for lidzas are contracture of the joints, scars after burns and surgeries, ankylosing spondylitis, hematomas, etc. The lidz solution (1 ml) is injected in these cases near the lesion under the skin or under the scarred tissue. Injections are made daily or every other day; The treatment consists of 6 - 10 - 15 and more injections.