Description drugs: Cytochrome c (Cytochromum C)
Cytochrome c (Cytochromum C).
The enzyme preparation obtained by extracting from the heart tissue of cattle and swine.
Available as a lyophilized powder (C Sutochromum lyophilisatum), that contain the 20 - 30% of cytochrome C and up to 100% sodium chloride. Pink-brown powder, easily soluble in water.
Tablets are prepared from the powder of cytochrome C (0.01 g) was dissolved in the gut (Ta buletta Sutochromi enterosolubiles 0.01 C). Tablets are pink-brown color. Available as cytochrome C for injections (Sutochromum With pro injectionibus) - 0,25% solution in isotonic sodium chloride solution. Transparent liquid reddish-brown color.
Cytochrome C is an enzyme involved in the processes of tissue respiration. Iron contained in the prosthetic group of the cytochrome C and reversibly changes from the oxidized form to the reduced, and therefore the use of the drug accelerates oxidation processes.
Refers to the group of cytochrome C antihypoxic funds (see. Antigipoksanty and antioxidants).
Apply for improved tissue respiration during neonatal asphyxia, asthmatic conditions, chronic pneumonia, heart failure, coronary heart disease, infectious hepatitis, senile degeneration of the retina, intoxication and other conditions involving violation of oxidative processes in the body.
Assign parenterally and inwardly.
Intramuscular (slow) and intravenous (drip) injected under pathological conditions mentioned above. Usually give muscle to 4 - 8 ml cytochrome C injection 1 - 2 times a day. The course of treatment 10 - 14 days.
In diseases drug hearts in the same dose applied to 200 ml of isotonic sodium chloride solution or 5% dextrose solution intravenously (30 - 40 drops per minute) for 6 - 8 h. During the day, administered 12 - 32 ml (30 - 80 mg ).
Postoperatively (surgery for congenital and acquired heart disease), and chronic coronary insufficiency drug injected 2 times per day by 4 mL (16 mg) per injection. In case of severe condition (trauma, shock, hepatic coma, poisoning hypnotic drugs, carbon monoxide) administered intravenously in an amount of 20 - 40 ml (50 - 100 mg). When injected into neonatal asphyxia umbilical vein during the first 2 minutes after birth at a dose of 4 ml (10 mg).
In bronchial asthma drug administered intramuscularly, 2 times a day for 2 - 4 ml (5 - 10 mg) per injection. The course of treatment lasts from 14 to 25 days depending on the stage and stage.
Before the start of the application of cytochrome C should determine individual sensitivity to it. For this purpose, injected intradermally with 0.1 ml of the drug (0.25 mg). If the 30 minutes is not observed facial flushing, itching, hives, it is possible to start drug treatment. Before the appointment of a repeat course is required to repeat the biological sample.
If you find you are hypersensitive to the drug is contraindicated.