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Description of the medicine: Pantrypinum (Pantrypinum)

Pantrypinum.

A drug obtained from the pancreas of large cattle.

Lyophilized powder of yellowish color. It is soluble in water and in isotonic sodium chloride solution.

Panthropine is a substance of a polypeptide nature that has a specific ability to inhibit the activity of trypsin, chymotrypsin, kallikrein, plasmin and other proteases.

The activity of pantripine is determined biologically by the ability to lower the activity of trypsin. In 1 g of the drug contains not less than 650 units.

The polyvalent antiprotease activity of pantrypine (as well as other similar protease inhibitors) determines its high activity in acute pancreatitis.

According to modern data, with acute pancreatitis the process of activation of pancreatic enzymes (trypsin, chymotrypsin, lipases, etc.) changes. Under physiological conditions, these enzymes are in the iron in an inactive (zymogenic) form and are activated only when entering the intestine. Violation of metabolic processes and the appearance of cytokinase (as a result of infections, injuries, stones, etc.) can lead to the release of activated enzymes in the pancreatic ducts, which causes self-digestion of the gland tissues, the appearance of interstitial hemorrhages, edema and other changes.

Applied for the treatment of acute pancreatitis and recurrences of chronic pancreatitis, the prevention of pancreatitis in stomach and bile duct operations if there is a risk of injury to the pancreas.

It should be noted that in severe cases, the use of pantrypine does not replace surgical intervention.

Enter intravenously. In severe forms of pancreatitis, 100-125 units of ED in 10-20 ml of 5% glucose solution or isotonic sodium chloride solution are administered simultaneously. Then the drug is administered dropwise in a dose of 25 - 30 U in 500 ml of 5% glucose solution (with the addition of insulin at the rate of 1 unit for every 3 to 4 g of glucose) or isotonic sodium chloride solution. Drop injections of pantripine solution are produced at a rate of 40-60 drops per minute. In the first day the drug can be injected repeatedly to a total dose of 250-300 units. In the next 24 hours, up to 120-150 units are administered (depending on the disease pattern). The injections are repeated until a clinical recovery.

For mild forms of the disease, the initial dose is 12-25 U, in the future, the dose is set depending on the patient's condition (injected drip).

With bile, duodenal, high intestinal fistulas, etc., drip 6 to 12 U; In the future, the dose is changed depending on the clinical picture; Administered once a day. Prophylactic (for operations on the abdominal organs) appoint 50 - 80 units.

Pantrypine is also used in cataract removal with chymotrypsin (see), to inhibit the excess action of the enzyme introduced into the eye's chambers.