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Description of the medicine: Pantripin (Pantrypinum)

PANTRIPIN (Pantrypinum).

The drug is obtained from the pancreas of cattle.

Lyophilized yellowish powder. Soluble in water and in an isotonic sodium chloride solution.

Pantripin is a polypeptide substance with a specific ability to inhibit the activity of trypsin, chymotrypsin, kallikrein, plasmin and other proteases.

Pantripin activity is determined biologically by the ability to lower trypsin activity. 1 g of the drug contains at least 650 units.

The polyvalent antiprotease activity of pantripine (as well as other protease inhibitors similar in nature to it) determines its high activity in acute pancreatitis.

According to modern data, in acute pancreatitis, the process of activation of pancreatic enzymes (trypsin, chymotrypsin, lipases, etc.) changes. Under physiological conditions, these enzymes are in the inactive (zymogenic) form in the gland and are activated only when they enter the intestine. Violation of metabolic processes and the appearance of cytokinase (as a result of infections, injuries, stone formation, etc.) can lead to the release of activated enzymes in the pancreatic ducts, which causes self-digestion of the gland tissue, the appearance of interstitial hemorrhages, edema, and other changes.

It is used to treat acute pancreatitis and relapse of chronic pancreatitis, to prevent pancreatitis in operations on the stomach and biliary tract, if there is a risk of injury to the pancreas.

It must be borne in mind that in severe cases, the use of pantripine does not replace surgical intervention.

Enter intravenously. In severe forms of pancreatitis, 100 - 125 IU is administered simultaneously in 10 - 20 ml of 5% glucose solution or isotonic sodium chloride solution. Then the drug is administered dropwise at a dose of 25-30 IU in 500 ml of 5% glucose solution (with the addition of insulin at the rate of 1 IU for every 3-4 g of glucose) or isotonic sodium chloride solution. Drop drops of pantripin solution are produced at a rate of 40-60 drops per minute. On the first day, the drug can be re-administered up to a total dose of 250-300 units. In the next day, up to 120 - 150 PIECES are administered (depending on the picture of the disease). Administration is repeated until clinical recovery.

In mild forms of the disease, the initial dose is 12 - 25 units, in the future the doses are set depending on the patient's condition (administered dropwise).

With bile, duodenal, high intestinal fistulas, etc., they are administered dropwise in 6 - 12 units; in the future, the dose is changed depending on the clinical picture; administered once a day. Prophylactically (during operations on the organs of the abdominal cavity), 50 to 80 units are prescribed.

Pantripin is also used in cataract surgery using chymotrypsin (see), to inhibit the excessive action of the enzyme introduced into the chambers of the eye.