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Description medications: Plasmin (Fibrinolysinum)

Plasmin (Fibrinolysinum).

Plasmin (or plasmin) is an enzyme, an activation of the blood plasminogen (plasminogen).

Plasmin (plasmin) is a physiological component of the natural anticoagulant system of the body. At the heart of the action of the enzyme is its ability to dissolve fibrin strands. This effect is observed in vitro and in vivo. The nature of fibrinolizin can be considered as protease tissue (tissue proteolytic enzyme). The most pronounced effect on fibrinolizina fresh fibrin clots prior to retraction. Due to these properties, fibrinolizin used to treat diseases associated with intravascular deposition of fibrin clots and the formation of blood clots.

Plasmin is prepared from human plasma plasminogen by its enzymatic trypsin activation. White hygroscopic powder. Soluble in izotonichesnom sodium chloride solution.

Drug activity determined by biological means, in their ability to cause lysis of fresh clot fibrinogen standard and expressed in units of (ED).

Apply fibrinolizin in cases of fresh thrombosis (for 1 nights stay in coronary vascular thrombosis and cerebral vascular thrombosis and peripheral arterial branches, if not come gangrene; for 5 - 7 days at a peripheral vein thrombosis). With the increase in the life of brain fibrinolizina efficiency decreases.

Currently, due to the broad introduction of streptokinase preparations, providing a more permanent fibrinolytic effect with less side effects; fibrinolizinom are relatively rare.

At therapeutic doses fibrinolysin not affect the blood clotting process and should be used in combination with anticoagulants (heparin). Heparin prevents further blood clots and provides the efficacy and safety of therapy. The need for fibrinolizina with anticoagulants is also determined by the fact that according to available data, fibrinolizin may cause activation of blood coagulation; In addition, after administration, may increase fibrinolizina antifibrinolytic properties of blood.

In a joint application with fibrinolizinom heparin administered in lower doses than when self-applied. It can also be used anticoagulants of indirect action (group bishydroxycoumarin and fenilina); they are applied immediately after the introduction fibrinolizina and heparin.

Enter drug intravenously. Plasmin, which is in dry form in a vial, dissolved in a sterile isotonic sodium chloride solution at the rate of 100 - 160 units in 1 ml. The solutions were prepared immediately before use, since on standing (uslaviyah at room temperature), they lose activity.