Description of the medicine: Nialamid (Nialamidum)
NIALAMIDUM. 1- [2- (Benzylcarbamoyl) ethyl] -2-isonicotinoylhydrazide.
Synonyms of nialamide: Niamid, Novazid, Nuredal, Espril, Niamid, Niaquitil, Nuredal, Nyazin, Psicodisten and others.
White or white with a weak yellowish tinge fine crystalline powder. It is slightly soluble in water, it is difficult - in alcohol.
Nialamid is one of the first-generation antioxidant antidepressants.
Chemically, nialamide is similar to iproniazide: both are derivatives of isonicotinic acid hydrazide (Iproniazide is excluded from the nomenclature of drugs)
Nialamide is an indiscriminate and irreversible MAO inhibitor, but it is somewhat less toxic than iproniazide. Despite the possibility of side effects when it is used, it has retained its importance as a medicinal product. According to available data, MAO inhibitors are often more effective than other antidepressants (tricyclics), at <atypical> depression.
Nialamid is used in psychiatric practice in depressive states of various nosological forms, combined with lethargy, inhibition, lack of initiative, including in involutive, neurotic and cyclothymic depressions.
Assign inside (after eating) in the form of tablets, ranging from 0.05-0.075 g (50 - 75 mg) per day, preferably in 2 divided doses (morning and afternoon) to avoid disturbance of night sleep; If necessary, the dose is gradually increased by 25-50 mg per day to 200-350 mg per day (in resistant cases sometimes up to 800 mg).
The therapeutic effect in the treatment with nialamide appears usually after 7 to 14 days. The duration of the course of treatment is individual (from 1 to 6 months). After the onset of therapeutic effect, the dose of the drug is gradually reduced.
In neurological practice, nialamide is sometimes prescribed for the treatment of trigeminal neuralgia and other pain syndromes.
There are indications that nialamide (0.025 g 2 - 3 times a day) reduces the frequency and intensity of angina attacks.
Published data on the effectiveness of nialamide (noredal) in the complex treatment of chronic alcoholism. The use of the drug (from 50 to 200 mg per day) improves the general condition and cognitive (cognitive) functions.
Nialamide is relatively well tolerated. In some cases dyspeptic phenomena, a decrease in systolic pressure, anxiety, insomnia, headache, dry mouth, stool retention and other side effects are observed.
The drug is contraindicated in patients with impaired liver and kidney function, with cardiac decompensation, cerebral circulation disorders (due to the possibility of orthostatic hypotension).
Do not prescribe nialamides to patients with agitated conditions.
When nialamide is prescribed, however, it is necessary to consider the possibility of developing side effects associated with MAO inhibition.