Description of the medicine: Nialamidum (Nialamidum)
NIALAMID (Nialamidum). 1- [2- (Benzylcarbamoyl) ethyl] -2-isonicotinoyl hydrazide.
Synonyms of nialamide: Niamide, Novazid, Nuredal, Espril, Niamid, Niaquitil, Nuredal, Nyazin, Psicodisten, etc.
Fine crystalline powder, white or white with a slight yellowish tint. It is slightly soluble in water, it is difficult in alcohol.
Nialamide is one of the first generation antidepressant inhibitors of MAO.
Chemically, nialamide is close to iproniazide: both are derivatives of isonicotinic acid hydrazide (iproniazide is excluded from the range of drugs)
Nialamide is a non-selective and irreversible MAO inhibitor, but it is slightly less toxic than iproniazide. Despite the possibility of side effects during its use, it retained its importance as a medicine. According to reports, MAO inhibitors are often more effective than other antidepressants (tricyclics) in "atypical" depression.
Nialamide is used in psychiatric practice for depressive states of various nosological forms, combined with lethargy, lethargy, lack of initiative, including involutional, neurotic, and cyclothymic depressions.
Assign inside (after eating) in the form of tablets, starting from 0.05-0.075 g (50 - 75 mg) per day, preferably in 2 divided doses (morning and afternoon) to avoid disturbance of night sleep; if necessary, the dose is gradually increased by 25 - 50 mg per day to 200 - 350 mg per day <in resistant cases, sometimes up to 800 mg).
The therapeutic effect in the treatment with nialamide usually manifests itself after 7-14 days. The duration of the course of treatment is individual (from 1 to 6 months). After the onset of the therapeutic effect, the dose of the drug is gradually reduced.
In neurological practice, nialamide is sometimes prescribed for the treatment of trigeminal neuralgia and other pain syndromes.
There are indications that nialamide (0.025 g 2 - 3 times a day) reduces the frequency and intensity of angina attacks.
Published data on the effectiveness of nialamide (nuredal) in the treatment of chronic alcoholism. The use of the drug (from 50 to 200 mg per day) improved the general condition and cognitive (cognitive) functions.
Nialamide is relatively well tolerated. In some cases, dyspeptic symptoms, a decrease in systolic pressure, anxiety, insomnia, headache, dry mouth, stool retention and other side effects are observed.
The drug is contraindicated in patients with impaired liver and kidney function, with decompensation of cardiac activity, cerebrovascular accident (due to the possibility of orthostatic hypotension).
Nialamide should not be prescribed to patients with agitated conditions.
When prescribing nialamide, however, it is necessary to take into account the possibility of developing side effects associated with inhibition of MAO.