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Description medicines: Gemfibrozil (Gemfibrozil)

Gemfibrozil (Gemfibrozil) *. 5- (2, 5-Dimethylphenoxy) -2, 2-dimetilpentanoevaya acid.

Synonyms: Gevilon, Dopur, Gevilon, Hipolixan, Lipigem , Lipozid, Lopid, Normolip and others.

Obtained as a result of the search clofibrate derivatives having less toxicity. Gemfibrozil turned low toxic and yet highly effective hypolipidemic agent reducing blood of patients with hypertriglyceridemia, VLDL, not reagiruyushih treatment diet and other lipid-lowering agents. Furthermore, it increases the concentration of HDL.

Gemfibrozil, Fast and almost completely absorbed by ingestion. The peak concentration in the blood observed after 1 - 2 h after administration. Provided mainly kidneys as glucuronide.

Assign an adult to 0.3 - 0.45 g 2 times a day (30 minutes before breakfast and dinner). The full therapeutic effect occurs after 3 - 4 weeks. Assign patients with hypertriglyceridemia when resistance to therapeutic diet and other lipid-lowering agents. When giperhilomikronemii due to family deficiency of lipoprotein lipase, the drug is ineffective.

Gemfibrozil is generally well tolerated. There may be gastrointestinal disorders (abdominal pain, nausea, diarrhea.). In rare cases, slight anemia, leukopenia. Like clofibrate (but rarely) may contribute to the formation of gallstones.

Contraindicated in patients with diseases of the gallbladder. The drug is not prescribed to pregnant women and children.

Potentiates the effect of anticoagulants.

Method of issuance: capsules to 0.3 g (300 mg); film-coated tablets (white), 0.45 g