Medication Description: Methionine (Methioninum)
D, L- a -Amino-g-methylthiobutyric acid.
Synonyms: Acimetion, Athinon, Banthionine, Meonine, Metione, Thiomedon.
A white crystalline powder with a characteristic odor (mercapto compounds) and a slightly sweet taste. Few soluble in water.
Methionine is one of the essential amino acids necessary to maintain the growth and nitrogen balance of the body. The special role of this amino acid in metabolism is related to the fact that it contains a mobile methyl group (-CH3), which can be transmitted to other compounds. Thus, it participates in the process of peremetilirovanie, which is very important for the vital functions of the organism (See also Choline Chloride, Calcium Pangamat.).
Methionine's ability to give a methyl group is due to its lipotropic effect (removal of excess fat from the liver). By giving up a mobile methyl group, methionine contributes to the synthesis of choline, which is associated with insufficient formation of phospholipids from the synthesis of fat and the deposition of neutral fat in the liver.
Protein casein (and the curd containing it), which contains a significant amount of methionine, also has a lipotropic property.
Methionine is involved in the synthesis of adrenaline, creatine and other biologically important compounds; activates the action of hormones, vitamins (B 12, ascorbic and folic acids), enzymes. By methylation and transsulfurization, methionine neutralizes toxic products.
Methionine is used to treat and prevent diseases and toxic liver damage (cirrhosis, lesions with arsenic drugs, chloroform, benzene and other substances), as well as in chronic alcoholism, diabetes, etc. The effect is more pronounced with fatty infiltration of liver cells. Methionine is not recommended for viral hepatitis. Methionine is prescribed for the treatment of dystrophy resulting from protein deficiency in children and adults after dysentery and other chronic infectious diseases.
The introduction of methionine in atherosclerosis causes a decrease in blood levels and cholesterol and an increase in the level of phospholipids. The ratio of phospholipids / cholesterol increases.
Assign inside 3-4 times a day. Single dose for adults 0.5 - 1, 5 g, for children under 1 year old - 0.1 g, up to 2 years - 0.2 g, from 3 to 4 years old - 0.25 g, from 5 to 6 years old 0.3 g, from 7 years old and older - 0.5 g. Accepted half an hour before meals. The course of treatment lasts 10 to 30 days. The drug can also be prescribed courses for 10 days with 10-day breaks. In connection with an unpleasant odor, methionine is prescribed to adults in coated tablets, and to children in tablets, as well as in a mixture with syrup, jelly, etc. When vomiting, methionine is canceled.
Method of issuance: powder; coated tablets, 0.25 g.
Storage: in well-sealed cans of orange glass in a dark place.
Rp .: Tab. Methionini 0.25 obd. N. 50