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Description of the medicine: Methionine (Methioninum)

METHIONINE (Methioninum).

D, L-a-amino-g-methylthiobutyric acid.

Synonyms: Acimetion, Athinon, Banthionine, Meonine, Metione, Thiomedon.

A white crystalline powder with a characteristic odor (mercapto compounds) and a slightly sweet taste. Slightly soluble in water.

Methionine is one of the essential amino acids necessary to maintain growth and nitrogen balance in the body. The special role of this amino acid in metabolism is due to the fact that it contains a mobile methyl group (-CH3), which can be transmitted to other compounds. Thus, it is involved in the process of methylation, which is very important for the life of the body (See also Choline chloride, Calcium pangamate.).

The ability of methionine to give a methyl group is due to its lipotropic effect (removal of excess fat from the liver). By giving a mobile methyl group, methionine promotes the synthesis of choline with insufficient formation of which is associated with a violation of the synthesis of phospholipids from fats and deposition of neutral fat in the liver.

Casein protein (and cottage cheese containing it), which contains a significant amount of methionine, also has a lipotropic property.

Methionine is involved in the synthesis of adrenaline, creatine and other biologically important compounds; activates the action of hormones, vitamins (B 12, ascorbic and folic acids), enzymes. By methylation and trans-sulfonation, methionine neutralizes toxic products.

Methionine is used to treat and prevent diseases and toxic lesions of the liver (cirrhosis, lesions with arsenic preparations, chloroform, benzene and other substances), as well as in chronic alcoholism, diabetes mellitus, etc. The effect is more pronounced with fatty infiltration of liver cells. In case of viral hepatitis, methionine is not recommended. Methionine is prescribed for the treatment of dystrophy resulting from protein deficiency in children and adults after dysentery and other chronic infectious diseases.

The introduction of methionine in atherosclerosis causes a decrease in blood cholesterol and blood levels and an increase in phospholipids. The coefficient of phospholipids / cholesterol is increased.

Assign inside 3-4 times a day. A single dose for adults is 0.5-1.5 g, for children under 1 year old - 0.1 g, up to 2 years old - 0.2 g, from 3 to 4 years old - 0.25 g, from 5 to 6 years old - 0.3 g, from 7 years and older - 0.5 g. Accepted half an hour before meals. The course of treatment lasts 10 to 30 days. The drug can also be prescribed in courses of 10 days with 10-day breaks. Due to the unpleasant odor, methionine is prescribed for adults in coated tablets, and for children in tablets, as well as in a mixture with syrup, jelly, etc. Methionine is canceled with vomiting.

Method of release: powder; coated tablets, 0.25 g each

Storage: in well-sealed jars of orange glass in a dark place.

Rp .: Tab. Меthionini 0.25 obd. N. 50