Medication Description: Lipofundin (Lipofundinum)
LIPOFUNDIN (Lipofundinum) *.
Fat emulsion prepared from purified soybean oil, emulsified using an isotonic (2, 5%) solution of glycerin, and containing particles (balls) of oil in size from 0.1 to 1, 0 micron, which corresponds to the size of chylomicrons in human blood.
A similar drug is also produced under the name "Intralipid" (Intralipid).
Lipofundin S 10% contains in 1 liter 100 g of soybean oil and 7, 5 g of soybean phosphatides; lipofundin S 20% - respectively 200 and 15 g.
Lipofundin (Intralipid) is used for parenteral nutrition in the postoperative period, with extensive burns, severe infectious diseases, unconscious conditions, cancer of the stomach and esophagus, and other conditions in which the use of drugs for parenteral nutrition is indicated.
There is evidence of the effectiveness of intralipid in acute pancreatitis (due to inhibition of pancreatic juice secretion).
Lipofundin is administered intravenously, usually at the rate of 1–2 g of fat per 1 kg of body weight per day, which is about 10–20 ml of lipofundin S 10% or 5–10 ml of lipofundin S 20%. The introduction of 500 ml of the drug should last about 3 to 5 hours (when using 10% of the drug) or 5 to 8 hours (when using 20% of the drug). It should start with 15-20 drops per minute during the first 10-15 minutes, then gradually (within 30 minutes) increase the number of drops (no more than 60 drops per minute).
After administration to the patient of the drug in a total dose corresponding to 1000 - 1500 g of fat, it is necessary to take a break in treatment, during which the blood plasma should become completely transparent. For serum enlightenment with the introduction of large doses of the drug should be monitored daily, especially in cases where there may be a violation of the transfer of fat and metabolism.
The drug is contraindicated in shock, myocardial infarction, stroke, severe liver disease, hyperlipidemia, nephrotic syndrome, severe atherosclerosis.
Product: in ampoules of 100 and 500 ml.
Storage: at a temperature of + 2 to + 8 'C. Freezing is not allowed.