Medication Description: Rheopolyglucinum (Rheopolyglucinum)
REOPOLIGLUKIN (Rheopolyglucinum). 10% glucose-dextran polymer solution (see Polyglukin) with a relative molecular weight of 30,000 - 40,000 with the addition of isotonic sodium chloride solution.
Transparent colorless or slightly yellowish liquid. Relative viscosity at temperature + 25 'С not more than 5, 5.
Reopoliglyukin is a drug of low molecular weight dextran. It reduces the aggregation of blood cells, promotes the movement of fluid from the tissues into the bloodstream. In this regard, the drug increases the suspension properties of blood, reduces its viscosity, helps to restore blood flow in small capillaries, has a detoxification effect, prevents and reduces the aggregation of blood cells.
Reopoliglyukin, like polyglukin, is excreted mainly by the kidneys, and about 70% is eliminated on the first day.
Applied with violations of the capillary blood flow, for the prevention and treatment of traumatic, operative and burn shock, violations of the arterial and venous circulation; for the treatment and prevention of thrombosis and thrombophlebitis, endarteritis; during heart operations performed using the heart-lung machine (to add to the perfusion fluid); in vascular and plastic surgery to improve local circulation; for detoxification with burns, peritonitis, pancreatitis, etc.
Reopoliglyukin prescribed for diseases of the retina and optic nerve (complicated myopia, retinal dystrophy, etc.), inflammatory processes of the cornea and choroid.
In order to prevent and treat capillary blood flow disorders associated with traumatic, operative and burn shock, 400-1000 ml (up to 1500 ml) of reopolyglucin intravenously are used intravenously (for 30–60 min). For surgical interventions on the heart and vessels, 10 ml / kg intravenously are administered intravenously before the operation, 400-500 ml during the operation, and 10 ml / kg per injection for 5-6 days after the operation.
In operations using the heart-lung machine, reopolyglukine is added to the blood at the rate of 10-20 ml / kg. For detoxification, 400-1000 ml is injected intravenously. If necessary, an additional 400 to 500 ml can be added on the same day, and 400 ml per day (drip) is injected over the next 5 days.
For children with various forms of shock, 5–10 ml / kg (up to 15 ml / kg) are administered. For cardiovascular operations, 10 ml / kg are administered to children under the age of 2–3 years once a day (for 60 minutes). , up to 8 years - at 7 - 10 ml / kg (1 2 times a day), up to 13 years - at 5 - 7 ml / kg (1 - 2 times a day), older than 14 years - a dose for adults. For detoxification injected at 5 - 10 ml / kg for 60 - 90 minutes.
In dehydrated patients, it is advisable to add isotonic sodium chloride solution or 5% glucose solution to reopolyglukine.
With a reduced filtration ability of the kidneys or, if necessary, restrictions on the introduction of sodium chloride, preopolyglukine with glucose is prescribed (see).