Medication Description: Reogluman (Rheoglumanum)
The drug is a 10% solution of dextran with a molecular weight of 40,000 # 10,000 with the addition of 5% mannitol and 0.9% sodium chloride in water for injection.
Transparent, colorless, odorless; pH 4, 0-6, 5; relative viscosity at a temperature of +25 ° C is not more than 7.0.
The drug is considered as a multifunctional blood substitute: it reduces blood viscosity, helps restore blood flow in small capillaries, reduces the aggregation of blood cells, has a detoxification, osmodiourtic, and hemodynamic action.
Reogluman is used to improve capillary blood flow in diseases involving microcirculation and fluid retention in the body, including traumatic, operative, cardiogenic, burn shock, and arterial and venous blood flow disorders (thrombosis; thrombophlebitis, endarteritis, etc.) for disinfection of thrombosis; with burns, peritonitis, pancreatitis, etc.
Reogluman is administered intravenously, drip. Begin with the introduction of 5 to 10 drops per minute for 10 to 15 minutes. After the introduction of 5 - 10 drops, and then 30 drops, take breaks for 2 - 3 minutes; if there are no undesirable reactions, go to the introduction of the drug at a rate of 40 drops per minute.
Doses and rate of administration are selected individually depending on the indications, the patient's condition, diuresis.
To maintain electrolyte balance, it is advisable to inject simultaneously with reoglyuman solutions containing potassium and sodium. In the complex therapy of shock, usually from 400 to 800 ml of reogluman is administered for 30–60 minutes (under the control of hemodynamic and diuresis parameters).
In cardiovascular surgery, 30 to 60 minutes before the operation, 10 ml / kg of reogluman is administered, 400 to 500 ml during the operation, and 5 to 6 days daily after the operation at the rate of 10 ml / kg.
In acute renal-hepatic insufficiency (with preserved filtration capacity), 400-800 ml is administered once; then daily (for 3–5 days) is used at the rate of 10 ml / kg for administration, under the control of the water-electrolyte and acid-base state and the blood coagulation system.
Possible complications, precautions and contraindications are the same as with the use of polyglucin. Do not apply reogluman with excessive hemodilution (hematocrit below 25%) and with hemorrhagic diathesis (thrombocytopenia).
Product: in bottles of 100; 200 and 400 ml.
Storage: at a temperature not lower than +10 and not higher than + 25 ° C. During transportation, a short-term storage temperature may drop to - 10 'C.