Description of the medicine: Haemodesum (Haemodesum)
A water-salt solution containing 6% low molecular weight polyvinylpyrrolidone (relative molecular weight 12,600 + 2,700) and sodium, potassium, calcium, magnesium, chlorine ions.
Polyvinylpyrrolidone (PVP) is a polymer compound; soluble in water.
Hemodez - a transparent yellow liquid; relative viscosity 1, 5 - 2, 1; pH 5, 2 - 7, 0.
It is used to detoxify the body in toxic forms of acute gastrointestinal diseases (dysentery, dyspepsia, salmonella, etc.), burn disease in the phase of intoxication, postoperative intoxication, infectious diseases, toxicosis of pregnant women and other pathological processes accompanied by intoxication.
Preparations similar to hemododesis are produced abroad under the names: Neocompensan, Рristan N, etc.
The mechanism of action of hemodesis is due to the ability of low molecular weight polyvinylpyrrolidone to bind toxins circulating in the blood and quickly remove them from the body.
The drug is rapidly excreted by the kidneys (up to 80% in 4 hours) and partially through the intestines.
It enhances renal blood flow, increases glomerular filtration and increases diuresis.
Hemodesis is administered intravenously at a rate of 40 to 80 drops per minute. If intravenous administration is not possible, subcutaneous is acceptable, but the effect in this case is less pronounced.
The solution is heated before administration to + 35; + 36 'C. Adults are once administered up to 300 - 500 ml; children 5 to 10 ml / kg.
Repeated infusions are made 12 hours or more after the end of the previous infusion.
The number of injections and the total number of injected hemodesis depend on the nature and course of the pathological process. In acute gastrointestinal diseases and intoxications, 1-2 infusions are usually sufficient. In case of a burn disease in the phase of intoxication (1st - 5th day of illness) and in the phase of intoxication of acute radiation sickness, 1 to 2 infusions are made, in case of hemolytic disease and toxemia of newborns, from 2 to 8 infusions (daily or 2 times a day).
Haemodesis can give a good detoxification effect in sepsis, but due to a possible decrease in blood pressure, careful monitoring of the patient's condition is necessary.
With a slow introduction, hemodesis usually does not cause complications. The introduction with increased speed can cause a decrease in blood pressure, tachycardia, difficulty breathing and require the introduction of vasoconstrictor and cardiac agents, calcium chloride.
The drug is contraindicated in bronchial asthma, acute nephritis, cerebral hemorrhage.
Release form: in hermetically sealed glass blood vessels for 100; 200 and 400 ml.
Storage: at a temperature from 0 to + 20 C. Freezing does not affect the quality of the drug.