Medication Description: Hemodez (Haemodesum)
Water-salt solution containing 6% low molecular weight polyvinylpyrrolidone (relative molecular weight 12,600 + 2,700) and ions of sodium, potassium, calcium, magnesium, chlorine.
Polyvinylpyrrolidone (PVP) is a polymeric compound; let's well dissolve in water.
Hemodez is a clear yellow liquid; relative viscosity 1, 5 - 2, 1; pH 5, 2 - 7, 0.
Used for detoxification of the body in toxic forms of acute gastrointestinal diseases (dysentery, dyspepsia, salmonella, etc.), burn disease in the phase of intoxication, postoperative intoxication, infectious diseases, toxicosis of pregnant women and other pathological processes accompanied by intoxication.
Preparations similar to hemodez are produced abroad under the names: Neocompensan, Reristan H, etc.
The mechanism of action of hemodesis due to the ability of low molecular weight polyvinylpyrrolidone to bind toxins circulating in the blood, and quickly remove them from the body.
The drug is rapidly excreted by the kidneys (up to 80% in 4 hours) and partially through the intestines.
It enhances renal blood flow, increases glomerular filtration and increases diuresis.
Introduced gemodez intravenously at a speed of 40 - 80 drops per minute. If intravenous administration is not possible, subcutaneous is acceptable, but the effect in this case is less pronounced.
The solution is heated before administration to + 35; + 36 'C. Adults once injected to 300 - 500 ml; children 5 to 10 ml / kg.
Repeated infusions are performed 12 hours or more after the end of the previous infusion.
The number of injections and the total number of hemodesis administered depend on the nature and course of the pathological process. In acute gastrointestinal diseases and intoxications, 1 to 2 infusions are usually sufficient. In case of a burn disease in the phase of intoxication (1 - 5th day of the disease) and in the phase of intoxication of acute radiation sickness, 1 - 2 infusions are produced; in hemolytic disease and toxemia of the newborn - from 2 to 8 infusions (daily or 2 times a day).
Hemodez can give a good detoxification effect in sepsis, but due to the possible lowering of blood pressure, careful monitoring of the patient’s condition is necessary.
With a slow introduction gemodez usually does not cause complications. Introduction with an increased rate may cause a decrease in blood pressure, tachycardia, difficulty in breathing and require the introduction of vasoconstrictor and cardiac agents, calcium chloride.
The drug is contraindicated in bronchial asthma, acute nephritis, cerebral hemorrhage.
Product: in hermetically sealed glass vessels for blood of 100; 200 and 400 ml.
Storage: at a temperature of from 0 to + 20 C. Freezing does not affect the quality of the drug.