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Medication Description: Sodium Bicarbonate (Natrii hydrocarbonas)

SODIUM HYDROCARBONATE (Natrii hydrocarbonas).

Synonyms: Sodium bicarbonate, Sodium bicarbonate, Soda bicarbonate, Natrium bicarbonicum, Natrium hydrocarbonic, Sodium bicarbonate.

White crystalline powder; odorless, salty-alkaline taste. Soluble in water (1: 2) with the formation of alkaline solutions (pH 5% solution 8, 1), practically insoluble in alcohol. Aqueous solutions are sterilized at a temperature of + 120 ° C for 12 min (in hermetically sealed vials with the addition of stabilizers).

Apply with various diseases, accompanied by severe acidosis (diabetes, infections, etc.), to combat acidosis during surgical interventions, etc.

Sodium bicarbonate is widely used (as well as other alkalis) as an antacid with increased acidity of gastric juice, gastric ulcer and duodenal ulcer.

Sometimes sodium bicarbonate is used in the form of intravenous drip infusions or rectal suppositories for hypertension, symptomatic renal hypertension and chronic renal failure. The effect is associated with an increase in the excretion of sodium and chlorine ions and an increase in osmotic diuresis. It is noted that against the introduction of sodium bicarbonate, the effect of antihypertensive drugs (rauwolfia drugs, etc.) is enhanced.

Sodium bicarbonate also facilitates the phenomenon of "motion sickness" (sea and airborne illness).

Due to the fact that the increase in alkaline blood reserves caused by the drug shifts the reaction of bronchial mucus to the alkaline side and makes the sputum less viscous, it is used as an expectorant.

Locally (in the form of rinsing, washes), sodium bicarbonate solutions are prescribed for inflammatory diseases of the eyes, the mucous membranes of the upper respiratory tract, etc., as well as for contact with mucous membranes and skin acids.

Apply sodium bicarbonate inside, intravenously, in candles, for enemas and topically (in the form of solutions).

When administered orally, the drug quickly neutralizes the hydrochloric acid of gastric juice and has a pronounced antacid effect. However, it is necessary to take into account that when neutralizing hydrochloric acid with sodium bicarbonate, carbon dioxide is released, which has a stimulating effect on the receptors of the gastric mucosa, increases the secretion of gastrin and may cause a secondary increase in secretion. In addition, when using large doses, an excess of antacid can be absorbed into the bloodstream and cause disturbances of the acid-base state.

Often sodium bicarbonate is prescribed together with anticholinergic agents (see Tablets "Bécarbon"), enveloping, adsorbing and other substances (see Tablets "Vikair", Tablets "Vikalin", etc.), while their therapeutic efficacy increases, side effects decrease .

Recently, drugs of new groups have received the main use as anti-ulcer drugs (see