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Description of the medicine: Sodium bicarbonate (Natrii hydrocarbonas)

SODIUM HYDROCARBONATE (Natrii hydrocarbonas).

Synonyms: Sodium bicarbonate, Sodium bicarbonate, Soda bicarbonate, Natrium bicarbonicum, Natrium hydrocarbonicum, Sodium bicarbonate.

Flavourless white crystalline powder, salty-alkaline taste. It is soluble in water (1: 2) with the formation of alkaline solutions (pH of a 5% solution of 8, 1), practically insoluble in alcohol. Aqueous solutions are sterilized at a temperature of + 120 ° C for 12 minutes (in hermetically sealed vials with the addition of stabilizers).

It is used for various diseases accompanied by severe acidosis (with diabetes, infections, etc.), to combat acidosis during surgical interventions, etc.

Widespread use of sodium bicarbonate (as well as other alkalis) has as an antacid with increased acidity of gastric juice, gastric ulcer and duodenal ulcer.

Sometimes sodium bicarbonate is used in the form of intravenous drips or rectal suppositories for hypertension, symptomatic renal hypertension and chronic renal failure. The effect is associated with an increase in the release of sodium and chlorine ions and an increase in osmotic diuresis. It was noted that against the background of the introduction of sodium bicarbonate, the effect of antihypertensive drugs (Rauwolfia preparations, etc.) is enhanced.

Sodium bicarbonate also alleviates the phenomena of "motion sickness" (sea and airborne illness).

Due to the fact that the increase in blood alkaline reserves caused by the drug shifts the reaction of bronchial mucus to the alkaline side and makes sputum less viscous, it is used as an expectorant.

Locally (in the form of rinses, rinses), sodium bicarbonate solutions are prescribed for inflammatory diseases of the eyes, mucous membranes of the upper respiratory tract, etc., as well as when acids are exposed to the mucous membranes and skin.

Apply sodium bicarbonate orally, intravenously, in suppositories, for enemas and topically (in the form of solutions).

When taken orally, the drug quickly neutralizes the hydrochloric acid of the gastric juice and has a pronounced antacid effect. However, it must be borne in mind that when neutralizing hydrochloric acid with sodium bicarbonate, carbon dioxide is released, which has an exciting effect on the receptors of the gastric mucosa, enhances the secretion of gastrin and can cause a secondary increase in secretion. In addition, when using large doses, an excess of antacid can be absorbed into the blood and cause disturbances in the acid-base state.

Often sodium bicarbonate is prescribed along with anticholinergic drugs (see Bekarbon tablets), enveloping, absorbent and other substances (see Vicair tablets, Vicalin tablets, etc.), while their therapeutic effectiveness increases, side effects decrease .

Recently, the main use as anti-ulcer drugs have received drugs of new groups (see