tetracycline

- The substance of this series have been obtained as a result of systematic verification of the huge number of soil samples for the maintenance of microorganisms capable of producing antibiotics. Chemically tetracycline - "base" is characterized in that it contains in the molecule fused chetyrehtsiklicheskuyu (tetra) system. A similar structure has other drugs in this group. They were active not only in regard to many cocci, but also against Rickettsia, Brucella, some large viruses, and protozoa (amoebae, trichomonads). Thus, spectrum breadth exceed penicillin and many other antibiotics. Tetracyclines after ingestion appear in the blood at 1 hour and then concentration for 2-6 hours it reaches a maximum level and then gradually decreases. Distributed in the body uniformly, but in the cerebrospinal fluid penetrate in relatively small amounts. Excreted in the urine within 1224 hours, for the most part unchanged. In severe septic conditions may be administered tetracycline in conjunction with penicillin, streptomycin, and others. Antibiotics. The highest dose for adult single - 0.5 grams daily - 2 years
Tetracyclines are generally well tolerated, but may also cause side effects: loss of appetite, nausea, vomiting, diarrhea, changes in the mucous membranes of the mouth and gastrointestinal tract (glossitis, stomatitis, gastritis). Can increase skin sensitivity to sunlight. Long-term use during the formation of the teeth (the appointment of children in the first months of life, as well as women in the last 3 months of pregnancy) can cause dark yellow teeth color. In the treatment of tetracycline necessary to carefully monitor the condition of the patient, with signs of elevated him sensitivity to make a break or switch to other antibiotics. To prevent side effects, the development of candidiasis (skin and mucosa) recommended both vitamins (tablets "Vitatsiklin"), antifungals (nystatin, Levorinum) imeyutsyatakzhe special pills containing tetracycline with nystatin. Tetracycline is contraindicated in degenerative diseases of the liver, impaired renal function, caution is needed during pregnancy and hypersensitivity to him and related antibiotics.
Tetratsiklinovayamaz - used in skin diseases: acne, furunculosis, folliculitis, trophic ulcers, eczema, etc. Bears in the lesion 1-2 times a day or use as a bandage for 12-24 hours. The treatment duration from a few days to 2-3 weeks. In case of itching, burning, redness of the skin treatment ointment stop.