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Doctors are perplexed

Is premenstrual syndrome a hormonal disease or is it due to psychosocial causes? There is very convincing evidence that it is associated with hormones, since during the week preceding menstruation, the level of female hormones, estrogen and progesterone changes, and during menopause, the symptoms that recur every month disappear. However, researchers who hospitalized women with a pronounced premenstrual syndrome and measured their hormone levels at different times have never found any significant deviations from the norm. The Englishwoman Carina Dalton, in one of her early works, advised using progesterone as a remedy for premenstrual syndrome. Although some women suffering from premenstrual syndrome reported that progesterone relieves them, even willing to swear to this, most studies have argued that the hormone helps nothing more than a placebo. In a limited study, women suffering from premenstrual syndrome received estrogen, usually prescribed in the case of pronounced menopause symptoms.
A little light on these contradictory data shed the most recent research described in an article published in the New English Medical Journal. In the course of these studies, those suffering from premenstrual syndrome were given medication that was supposed to prevent hormonal changes, usually occurring in the premenstrual phase of the cycle. However, the condition of women receiving such medication has not changed for the better, which led the researchers to think about other causes of the disease, perhaps the syndrome is caused by hormonal changes in another phase of the cycle or the disorder does not have a causal relationship with the menstrual cycle, but only synchronized with it in time .
Some researchers have studied the possible connection between premenstrual syndrome and thyroid dysfunction, seasonal emotional disorder, and circadian rhythm disturbances, which are treated with a full spectrum radiation dose. But until now, premenstrual syndrome remains as mysterious as in 1931, when obstetrician Robert Frank, MD, first used this term to describe a cyclical psychological disorder suffered by his patients.