Esophageal carcinoma

Esophageal carcinoma. It is usually diagnosed at the age of 55 years and older, in men it is 3 times more often than in women. Russia is characterized by uneven morbidity in different republics: the highest in Kazakhstan, Turkmenistan, and Uzbekistan.

The main histological form is squamous cell carcinoma. Malignant tumors are preceded by chronic esophagitis, peptic ulcers, chemical and thermal burns. Aetiological importance is also the systematic use of very hot food, micro-burns and micro-traumas of the esophagus, the effect of aflatoxins, nitrosamines, alcohol, lack of vitamins A and C.

Esophageal cancer can be ulcerative, warty-papillomatous and infiltrating. Most often, tumors are located in the middle third of the esophagus (60%), then in the lower third (30%), less often in the cervical region.

Symptoms: dysphagia (first there are difficulties in swallowing solid foods, then semi-liquid and liquid, dysphagia progresses continuously), pain (also during swallowing), salivation (usually with upper cervical and upper thoracic cancer), weight loss and dehydration.

X-ray and endoscopic examination allows to reveal the level of narrowing of the esophagus, to determine the size of the tumor, the presence of ulceration. The final diagnosis is made after a biopsy. Patients die from complications associated with the primary tumor (perforation, causing mediastinitis, exhaustion), and from distant metastases (lymph nodes, lungs, liver).

Treatment. The main method of treatment - surgical or combined (radiotherapy in combination with the operation). Palliative operations such as gastrostomy can be performed. Radiation treatment as the only method is also possible. When chemotherapy is used, adriablastin, fluorouracil, methotrexate, cisplatin, bleomycin, prospidin.