Discipuititarianism youthful

Dyspituitarism youthful - dysfunction of the hypothalamic-pituitary system with increased secretion of adrenocorticotropic hormone and growth hormone, a violation of the secretion of thyrotropic and gonadotropic hormones; Is observed in the pubertal period of life.

Etiology, pathogenesis. Infections, injuries, obesity from early childhood, reduction in physical activity, cessation of systematic exercise. Against this background, the age-related physiological activation of the neuroendocrine system leads to its dysfunction.

Symptoms, course. It is equally observed in boys and girls aged 12-23 years, mainly in 15-18 years. Characterized by tall, more often in young men (sometimes subgigantism). Obesity of II-III degree, even. On the skin of the chest, abdomen, hips, shoulders - multiple pink or red stretch bands, often short, superficial. Sexual development can be normal, accelerated or delayed. The increase in mammary glands (gynecomastia) in young men and the violation of the menstrual cycle in girls. Often there is transient hypertension (more often in young men).

On the radiographs of the skull are signs of intracranial hypertension, areas of calcification of the dura mater in the region of the Turkish saddle. On EEG - signs of a violation of the function of nonspecific structures of the midbrain and diencephalic region. Some of the patients have impaired glucose tolerance, increased the function of the adrenal cortex, and there is hyperinsulinism. The course of the syndrome is usually benign.

Treatment. Diet with reduced calorie and increased physical activity normalize body weight, while reducing other symptoms of the disease. In the hospital, a special diet is prescribed (1200-1500 kcal, 80-100 g protein, 70-80 g fat, 80-120 g carbohydrates), anorexic drugs (fepranone, desopimon, biguanides), spironolactones, diuretics, thyroid drugs, adiposine . To improve the functional activity of the brain, courses are prescribed with cerebrolysin (20-40 injections per course), aminalon (for 1-3 months), nootropil, stugeron, cavinton, cinnarizine (1-3 months). When violating glucose tolerance, biguanides are used. With symptoms of sexual insufficiency, young men are prescribed chorionic gonadotropin 1500 ED 2-4 times a week (courses of 3-4 weeks). Treatment of juvenile forms of obesity is the prevention of the development of diabetes mellitus, hypertension, infertility.