Vitamin B2 deficiency ( riboflavin.Hypo- or ariboflavinosis occurs with a lack of vitamin B2 in food, a violation of its absorption in the intestine, digestion or with increased destruction in the body.Riboflavin is found in many products of animal and plant origin.The daily requirement of an adult is 2- 3 mg In the body, riboflavin, interacting with ATP, forms flavimmono- and flavindinucleotides involved in the regulation of oxidation-reduction processes.Current hypoxia arises with ariboflavinosis.Riboflavin takes part in the visual function of the eye and the synthesis of hemoglobin.In the pathogenesis of ariboflavinosis, Other B vitamins.

Clinical picture. Characteristic are a decrease in appetite, weight loss, weakness, headache, twilight vision, dystrophic changes in the skin and mucous membranes, burning sensation of the skin, eye pain, conjunctivitis, angular stomatitis (cracks and maceration of the epithelium and crusts in the corners of the mouth), aphthous stomatitis, Glossitis (tongue bright red, dry), seborrheic dermatitis, especially pronounced in the nasolabial folds, on the wings of the nose, ears, dry itchy dermatitis on the hands. With a prolonged course, there are disorders of the nervous system: paresthesia, increased tendon reflexes, ataxia, etc., as well as hypochromic anemia. The course is chronic, with exacerbations in the spring-summer months.

The diagnosis is based on characteristic clinical signs, biochemical studies (demonstrably a decrease in riboflavin in the daily urine below 100 μg, hour urine below 10 μg, serum levels below 3 μg / l, and erythrocytes below 100 μg / l). It is important to reduce the dark adaptation. Differential diagnosis is carried out with pellagra, avitaminosis A, multiple sclerosis. In doubtful cases, the results of studies of the content of vitamins in blood and urine are most convincing.

Treatment. Full nutrition, riboflavin inside for 10-30 mg for 2-4 weeks. At the same time, prescribe other vitamins of group B. With endogenous insufficiency, treatment of intestinal diseases accompanied by impaired absorption.