Prycchinot is true
Pemphigus true (pemphigus acantholitic) is a disease of unknown etiology, characterized by the appearance on the mucous membranes and skin of blisters and erosions prone to peripheral growth and toxicosis. A certain role in the etiology belongs to autoimmune processes, leading to acantholysis and the formation of intraepidermal blisters.
Symptoms, course. The main form is vulgar pemphigus. The process usually begins on the mucous membrane of the mouth, sometimes the larynx, where thin-walled blisters are formed, which are quickly opened. Erosions are located on the unmodified mucosa. On the skin there are bubbles with transparent contents, after the opening of which there are bright red colors of erosion, prone to growth. On the surface of erosions, crusts can form. The skin around is not changed. Positive symptom of Nikolsky. The process without treatment progresses, the rashes merge, cover large areas of the skin, toxicosis is attached, a fever is possible. Variants of pemphigus - seborrheic, leaf-shaped and vegetative forms. Acantholytic cells are found from the surface of erosions in swabs-prints.
Treatment. Corticosteroids are first prescribed in a shock dose (60-100 mg prednisolone per day). After the onset of remission, the dose is gradually reduced to maintenance (10-15 mg per day), which is administered continuously. Corticosteroids can be combined with cytostatics (methotrexate), gamma globulin, antibiotics, hyperbaric oxygenation. The abolition of corticosteroids or a rapid decrease in their daily dose causes an exacerbation of the disease.
The prognosis without treatment is poor. Corticosteroids cause remission, sometimes persistent, allowing gradual discontinuation of treatment. Work capacity is limited.
- Skin and venereal diseases
- Actinomycosis of the skin
- Alopecia
- Angiitis (vasculitis) of the skin
- Atopic dermatitis (diffuse neurodermatitis)
- Balanoposthitis
- Warts
- Vitiligo
- Gonorrhea
- Dermatitis
- Ichthyosis
- Candidiasis
- Itching itch
- Condyloma spikelets
- Hives
- Lyell's syndrome
- Leprosy
- Lymphogranulomatosis of inguinal
- Leaven red flat
- Lichen otripeda
- Pink lichen
- Mastocytosis
- Microsporia
- Molluscum contagiosum
- Pyoderma
- Pocerucha (Prurigo)
- Psoriasis
- Skin cancer
- Rosacea
- Rubrophytia
- Seborrhea
- Syphilis
- Stevens-Johnson syndrome
- Toxidermia
- Lupus
- Acne vulgaris (youthful)
- Favus (scab)
- Scabies
- Chancre soft
- Eczema
- Epidermophytia
- Erythema nodosum
- Erythrasm
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