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Silent Oncology Revolution

Тихая революция в онкологии

Oncology (Greek onkos, tumor + logos, word, teaching) is a branch of medicine that studies benign and malignant tumors, the mechanisms and patterns of their occurrence and development, methods for their prevention, diagnosis and treatment. Oncological diseases are a vast and heterogeneous class of diseases. Oncological diseases are systemic and affect, in one way or another, all human organs and systems. There are many forms and options for treating cancer. Although patients often perceive a diagnosis of cancer as a sentence, not all, even malignant tumors, lead to death. Modern studies have shown that every person in the body regularly develop cancer cells and micro-tumors, which die and dissolve under the influence of an antitumor immunity system.

Quiet revolution in oncology - the key word here is SILENT. But this is the very case when silence should be broken by tom-toms, timpani and revolutionary volleys of the Aurora. And all because in medicine there was a real revolution. And everyone should know about it. This is a genuine, rather than bloated sensation. This is not theory, but practice. This should be written and broadcast at every turn. And then the lives of many people will be saved, including those who no longer have the slightest hope for it.

The last few years, we are witnessing a truly revolutionary changes in medicine. Unfortunately, such developments have not yet reached all countries, moreover - not all doctors are aware of what is happening.

In this article I want to talk in general terms about the breakthrough in the treatment of a number of the most severe oncological (and not only) diseases that until recently were considered incurable. In addition, as a practicing Israeli doctor, I will cite cases from personal experience using examples from my patients from the former CIS countries. As they say - from the first person.

So what is it about?

First of all, we are talking about new biological and immunological drugs that have already proven to be highly effective in treating many types of diseases such as lung cancer, metastatic melanoma, kidney cancer, bladder cancer, breast cancer, colon cancer, stomach cancer, hepatitis C and many others. Moreover, these drugs help precisely in cases with advanced stages of the disease, with the already metastasis of the tumor.

As is known, conventional chemotherapy has a systemic effect on the entire human body, destroying both cancer and healthy cells. The most obvious example of this is hair loss during chemotherapy.

Biological drugs also act pointwise - destroying only genetically modified cancer cells of the body, and without affecting healthy ones. For example, Zelboraf) blocks the serine-threonine kinase, which is encoded by the BRAF gene, which, in turn, is responsible for the development of melanoma. A patient is undergoing genetic research and, if the BRAF mutation is confirmed, Zelboraf is a salvation for such patients.

I have a 56-year-old patient who was operated on in connection with melanoma of the back skin 10 back. A year ago, he had metastases in his lungs, spine and brain. After confirming the presence of the BRAF mutation, the patient began to receive Zelboraf, and within a month all metastases disappeared.

Immunological drugs act on a different principle. They train and mobilize the human immune system to fight cancer cells. A cancerous tumor is an out of control group of cells with a failure in the DNA that can be disguised and become invisible to the immune system, which normally can cope with the single cancer cells that constantly appear in the human body. Immunological drugs remove masking from cancers, giving the "fas" immune system that begins to destroy the tumor throughout the body, including remote metastases - without harming healthy cells. That if in a nutshell. If, for example, a genetic study on BRAF in a patient with metastatic melanoma does not show the presence of a mutation, he is given an immunological drug - Opdivo. And I have such patients too.

Other examples of treatment with the latest biological and immunological drugs can be cited: Today, 90-98% can cure hepatitis C, which is deadly, no less than cancer, with modern drugs such as Harvoni and Sovaldi (Sovaldi). , Vierax, Exviera, even in those patients who have already been unsuccessfully treated with interferon and ribovirin, and are in advanced stages of liver cirrhosis.

Such drugs as Opdivo (Opdivo), Keitruda (Keytruda), Erbitux (Erbitux) and others enter into remission of patients with metastatic cancer of the kidney, bladder, lungs, intestines, chest.

The mere emergence of these drugs is a huge breakthrough, and in Israel their use is the standard.

But that is not all.

Recently, we have begun to conduct some of our patients the latest personal genetic research . They are carried out on the basis of a blood test or tumor tissue obtained as a result of an operation or a biopsy and, in terms from a week to three, give answers to a number of important questions:

  • Genetic analysis of the tumor - specific mutations (changes in the structure of the tumor at the cellular level), allowing to provide effective treatment with a specific biological drug
  • What is the effect of different types of chemotherapy on a particular patient’s tumor? This study is akin to many years of the well-known study of the sensitivity of bacteria to antibiotics, only studies the sensitivity of tumor cells to chemotherapeutic drugs.
  • What is the wagging of all types of biological preparations for a specific type of tumor of a given patient?
  • What is the effect of immunological drugs on a specific type of tumor in a given patient?
  • Urgency of treatment (depending on the type of tumor)
  • Possibility of early detection of oncology early detection for family members of the patient

These studies are recommended in cases where:

  • Patients received several treatment protocols with no visible results.
  • Tumor does not respond to treatment
  • For types of cancer with low chances of cure
  • For tumors from an unknown source
  • So what is the breakthrough here?

    The fact is that these studies are personalized - they provide answers for treating a specific type of cancer of a particular patient .

    And, accordingly, make it possible to pre-select the drug that will be most effective for this patient. That is, to immediately select the most effective medicine and its dosage, without spending many months using the “trial and error” method. After all, it is often a matter of life and death.

    And, besides, biological and immunological drugs are currently quite expensive, so the preparation selected in advance on the basis of genetic research saves not only time but also a lot of money.

    By the way - about the money.

    As I have already said, the problem with the drugs under discussion is their high price, although in recent months prices have begun to decline significantly, and I expect this trend to continue.

    But is it possible to value human life with money? Indeed, more recently, many of these diseases could not be cured for any money.

    Anyway, personally using the described methods of treatment, I can say with confidence that modern science and medicine have made a serious breakthrough in the treatment of a large number of serious diseases.

    And for a snack: Last August, Jimmy Carter, the former US president, said that he had cancer with multiple metastases. And already at the beginning of December, he said that after the course of treatment with the immunological preparation “keytruda”, which, by the way, was undergoing clinical trials in Israel, there were no traces of the disease in his body.

    Israeli medicine is once again one of the first in the world to develop and adopt the latest medicines and technologies. And I am pleased to feel my involvement in this process.