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Prohibited, falsified and useless drugs and their manufacturers

Annotation to the unauthorized replacement of more expensive drugs on their cheap counterparts

Many readers were hooked by the phrase about the unauthorized replacement of more expensive drugs with their cheap counterparts, on the advice of the “most affluent patients with difficult financial situation” of first-timers. Well, there is a saying ... A wolf regretted a mare ... left a tail and a mane ... Shouts that here .... they say evil doctors with anger prescribe insanely expensive treatment when it would be possible to get by with less expensive ... they start a few to strain therefore, to the best of power, a small explanation.

In your life there is no more necessary and important purchase for you than the purchase of medicines necessary for your health. Therefore, saving is not necessary. You can save on books, going to the cinema and theater, clothes, fashionable booths and devices, drinking ... if it’s really bad, then on food.

The fact is that sometimes the price / quality difference does not fall within the framework of ordinary consumer behavior. Sometimes (and more often not) the quality is better "slightly", and the price doubled ...

In the case of buying furniture, building materials and laundry detergent, probably not .... however, everyone will decide. But in the price / quality ratio in the case of a medicine, “quality” is the quality of your one and only life + risks of developing side and unpredictable effects, of course. Of course, you ultimately decide ... but, I have been trying not to risk for a long time ....

The most important is the predictability of the drug, the predictability of possible side effects, the predictability of the interaction with other treatments, etc., etc.

What is guided by the doctor? First of all, their personal experience and data colleagues. Recently, “evidentiary” or “demonstrative” medicine has also appeared, which allows objectively combining the experience of many doctors, but this is a topic for a separate message, and there are also some pitfalls ...

So, the experience of each doctor is based on the use of a large, but in general, a limited number of drugs, nothing can be done about this is life. Because everyone wants the predicted results of treatment, and no one wants to be a guinea pig.

Tells professional pharmacist

Oh, what a pity that I later found this topic, but I have a lot to say about cheap analogues. So, in a nutshell. We take the very first one, according to the list, or the second or third, we prepare the sample, put the chromatograph in the chromatograph - the output is a candy. The peak of the main substance, a pair of three tiny spikes of impurities and everything. Then we take a cheap analogue, put it in the device in exactly the same way and ... Squish from the paling of any rubbish that crawls on the chromatogram.

The trick is that the expensive drug is made from high-quality raw materials, most often American, Canadian or Israeli (well, something else happens in Europe, but this is rarely already). And generic drugs are boiled from Sino-Indian trash, miles sorry, so control over the raw materials is much more approximate. Accordingly, at least due to impurities, we have an elegant distortion of the mechanism of action of the drug. Raw materials are controlled by a certain final list of parameters, and inorganic impurities are generally checked very conditionally. And they may be there - Mama Do not Cry.

In my personal rating, the top position is the story of an American aunt who decided to spoil an aspirin batch of hellish emotions by shaking a decent dose of rat poison into the reactor. Do you think it was discovered during production and pre-sales control? And nifiga! Arsenic is not included in the standard test list, and if you do not specifically look for it, then by chance you will not find it in life. Thank you, my aunt thought better of it and surrendered to the police, they managed to withdraw aspirin from the sale ... It’s just me that the inorganics are “caught” extremely difficult, and there can be trouble from her - don't you grieve! And how much of the inorganics in Indian and Chinese raw materials, which are most often produced in violation of the basic requirements of Good Manufacturing Practices, is unknown to anyone at all.

In general, this is my main professional callus ... I apologize for the wordiness. It’s just a fucking cloud of years in pharmaceutical production, of which 10 years in Canada, I’m a little nervously responding to the phrases "there is a cheap analogue," because the answer to this is, like Zhvanetsky, "you are those who have or are treated."


If you do not trust the doctor who prescribed you, in your opinion, an unreasonable expensive / harmful / unnecessary treatment - nothing terrible, it happens. Only in such a situation it is necessary to change the doctor, and not the one prescribed by him. And if you trust the professionalism of your doctor ... please leave creative approaches for some other area.

Black list of drugs (Black list of Roszdravnadzor)


- LLC “Iodine technologies and marketing” (45 series of four drugs were rejected)
- Tula pharmaceutical factory (26 series of seven drugs)
- CJSC Vifitekh (22 series of eight drugs)
- LLC Slavic pharmacy
- Association of JSC "Biosintez"
- JSC "Tatkhimpharmpreparaty"
- CJSC Rostov Pharmaceutical Factory
- OJSC "Dalkharmharm"
- JSC "Biochemist"
- OJSC Flora of the Caucasus


(Indian pharmaceutical companies heading the list)
- Plethico Pharmaceuticals Ltd (India
- “Shrey Life Sciences Pvt. Ltd. "
- “Himalaya Drag Co.”
- The English company "Rekitt Benkizer Helsker International Ltd" ("Boots Helskar International")
- Ukrainian OJSC “Farmak”
- Belgian “YUSB S.A. Pharma Sector "
- Netherlands "Natur Product Europe BV"
- Pakistan Herbion Pakistan Private Limited
- Belarusian Unitary Enterprise "Belmedpreparaty"
- American "Sagmel Inc."

Most often forged:

(name; number of fakes; average. retail. price (rub.))
- Trichopol ; 41619; 39.5;
- Mezim-forte ; 9334; 40;
- Valocordin ; 8910; 60;
- Festal ; 8445; 156;
- Novo-Passit (solution) ; 7622; 89;
- Essentiale-Forte N ; 5888; 235;
- Claritin ; 3153; 174;
- Suprastin ; 1040; 70


Phenacetin - Prohibited Medical Use
Cimetidine - Prohibited Medical Use
Hemodez - Prohibited Medical Use
Phenylbutazone (Butadion) - Medical Use Limited
Gentamicin - Limited Medical Use
Nitrofural (furatsilin) - Prohibited medical use of oral tablets
Nitrofuran - Limited Medical Use
Detoxification Solutions Containing Low Molecular Polyvinylpyralidone - Limited Medical Use

Metamizole Sodium (Analgin) - Limited Medical Use

  • limiting the age of children when administered in tablet form - up to 12 years;
  • there are groups of patients who may have a risk of PR (with a burdened allergological history, blood diseases, impaired liver and kidney function);
  • the duration of the continuous use of these drugs is not more than 3 days for all age groups (in the average therapeutic dose for adults 0.5 -1.0 grams);

Rofecoxib (Rofic, Denebol) - Medical Use Limited

  • maximum daily dose is limited (not higher than 50 mg per day)
  • contraindication to use - people with an increased risk of the cardiovascular system (endured heart attacks, strokes, progressive clinical forms of atherosclerosis); age over 65 years.

Thioridazine (Sonapax, Ridazin) - Medical Use Limited

  • the highest daily dose is limited (not higher than 300 mg per day)
  • indications for use: limiting mental states, psychoneurotic states, mental disorders of alcoholic origin

Nimesulide Preparations - Limited Medical Use

  • use is forbidden in children under 12 years old;
  • simultaneous use with potentially hepatotoxic agents
  • alcoholism, drug addiction
  • increased body temperature and flu-like condition

Eufilin - Medical use of medical forms that contain the stabilizer ethylenediamine is prohibited.

Prepare Oseltamivir (Tamiflu) - Changes have been made to the Instructions that relate to the potential risk of neuropsychiatric disorders associated with the use of Tamiflu, especially in children.

The experts got into attention:

  • Abilify schizophrenia medicine manufactured by Bristol Myers Squibb Co. Clinical trials have shown its toxicity and harm to the liver.
  • Xenical slimming drug from Roche Holding AG due to the risk of rectal bleeding.
  • Antidepressants - inhibitors of serotonin reuptake and norepinephrine - due to the risk of congenital anomalies in children of persons taking these drugs.
  • Antifungal drug Lamisil from Novartis AG from Roche due to the risk of mental disorders.
  • The drug for high blood pressure Diovan from Novartis AG - for the development of anemia.
  • Oral contraceptives Plan B (Postinor and Escapelle) from the Israeli company Teva Pharmaceutical Industries - a high risk of loss of consciousness.