GANGRENA is one of the forms of necrosis (necrosis) of tissues. Cause gangrene often are damaged large arterial vessels, plugging them by thrombus or embolus, vascular lesions in atherosclerosis, obliterating endarteritis et al. Development gangrene promote long vasospasm, increased blood clotting, chronic intoxication (alcohol, phosphorus, nicotine), starvation, frostbite , endocrine diseases, especially diabetes mellitus , vitamin and cardiovascular insufficiency. Gangrene can occur in different tissues and organs, but gangrene of the extremities is more common.
Distinguish between dry and wet gangrene. With dry gangrene, a picture of coagulation necrosis is noted, mummification of the affected organ or tissue occurs. Wet gangrene occurs when a putrefactive infection develops in dead tissue. Under the influence of proteolytic enzymes, the tissues melt and take on the form of a fetid, dirty-gray mass. In wet gangrene intoxication is pronounced.
When treating dry gangrene, it is recommended to wait for the formation of a demarcation line (a clear boundary between necrotic and healthy tissues), and then to perform amputation within healthy tissues. When gangrene is small areas of the body (nail phalanx, tip of the nose, part of the auricle) dead tissue can separate on their own. With progressive wet gangrene, early amputation is necessary during detoxification therapy.