RED LUST SYSTEM (SCR)
RED LAMP SYSTEM (SLE) - a disease related to diffuse connective tissue diseases, which were previously called collagen diseases, or collagen diseases. Provocative factors are infections, insolation, vaccination, the use of certain drugs. Women at the age of 20-30 are predominantly ill.
The initial clinical manifestations of the disease can be fever resistant to antibiotic treatment, articular syndrome, skin rashes, occurring in isolation or in combination with each other. Almost all patients have articular syndrome in the form of arthralgia or polyarthritis with a predominant lesion of the interphalangeal and wrist joints. Characterized by skin lesions, manifested by erythematous rash on the nose and cheeks, having the appearance of a butterfly. Typical appearance of erythema under the influence of solar or ultraviolet radiation. On the skin of the terminal phalanges of the fingers and toes, small erythematous spots with small punctures and telangiectasias (capillaries) can be observed. Often revealed pleurisy, usually bilateral, recurrent, with a small amount of fluid and a tendency to adhesive processes. Damage to the lungs is possible, manifested by coughing, shortness of breath, and sometimes hemoptysis. Heart disease can manifest signs of myocarditis, endocarditis with the formation of mitral valve disease or pericarditis (intermittent pericardial friction noise). More than half of the patients have kidney damage in the form of diffuse glomerulonephritis (lupus nephritis), nephrotic syndrome with a gradual development of renal failure. Characterized by leukopenia , moderate anemia and thrombocytopenia, increased ESR. When the process is active in the blood, lupus cells (LE cells) are detected, which are mature neutrophils, in the cytoplasm of which there are large inclusions. Detection of LE cells has important diagnostic value.
The course of the disease is characterized by alternating periods of exacerbations and remissions. Subacute (most often) and chronic (benign variant) disease course is distinguished.
Treatment is usually complex, includes active anti-inflammatory and immunosuppressive therapy, as well as rehabilitation measures. The main treatment method is the use of corticosteroids. The initial (suppressive anti-inflammatory) dose is 40 - 60 mg of prednisone per day. After the suppression of activity, they switch to maintenance doses (5-10-15 mg per day). Cytotoxic drugs (azathioprine), nonsteroidal anti-inflammatory drugs, anticoagulants, antiplatelet agents are also used. In some cases, hemosorption, plasmapheresis. With a decrease in the activity of the process, it is possible to carry out rehabilitation activities - physical therapy, massage, sanatorium-resort treatment in the conditions of local sanatoriums. Patients with SLE should be under constant follow-up.