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Drug treatment of excessive sweating

Tablets, by mouth, or systemic drugs are sometimes prescribed by doctors to treat excessive sweating (hyperhidrosis). For this purpose, antholinergic drugs, beta-blockers, clonidine are used. (propantheline, glycopyrronium, benztropine, diazepam, diltiazem, indomethacin, oxybutynin, glycopyrrolate, robinul). Theoretically, these drugs can help in the treatment of excessive sweating, because they prevent the stimulation of all sweat glands and can reduce sweating in general, however, prolonged use is not recommended due to pronounced adverse events. In fact, many doctors are not convinced that systemic anticholinergics and other tablet preparations can be used to treat primary local hyperhidrosis (excessive sweating not associated with any other medical condition and localized in the arms, legs, face, and armpits).

Effective use of anticholinergic drugs

As noted above, specialists do not consider possible the long-term use of anticholinergic drugs or other tablets for localized hyperhidrosis (excessive sweating of the palms, feet, face and underarms), mainly due to severe and serious adverse events, such as:

  • Dry mouth
  • Accommodation disturbance (focusing vision)
  • Disturbance of speech, taste, difficulty chewing and swallowing
  • Urinary retention
  • Constipation
  • Heart rhythm disorders

There is one very interesting application of anticholinergic drugs. Some doctors and patients achieve great success in the treatment of excessive sweating of the palms and feet with the addition of crushed tablets of anticholinergic drugs in water during iontophoresis.