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INVENTION
Patent of the Russian Federation RU2147877

METHOD OF TREATMENT OF LEGS OF THE STOMACH AND TWELFTH DIAGNOSTIC

The name of the inventor: Chernekhovskaya NE; Mumladze RB; Andreev VG; Galaeva EV; Yeliseyeva ES; Kolyshkin VF; Varaksin MV; Bolotnikov AI; Bobrova M.N.
The name of the patent holder: Chernekhovskaya Natalya Evgenievna; Mumladze Robert Borisovich
Address for correspondence: 123480 , Moscow, ul.Vilisa Latsisa, 41, sq. 44, Chernekhovskaya N.E.
Date of commencement of the patent: 1999.09.13

The present invention relates to gastroenterology and can be used to treat gastric and duodenal ulcers. Oil "Ozonid" is applied to the ulcer during gastroduodenoscopy in a dose of 3 ml. The sessions are repeated every other day until a red scar appears. The method makes it possible to achieve complete epithelialization of gastric and duodenal ulcers without the use of additional antiulcer therapy.

DESCRIPTION OF THE INVENTION

The invention relates to medicine, in particular to gastroenterology, can be used to treat patients with peptic ulcer of the stomach and duodenum, which manifests itself in pain in the epigastric region, nausea, vomiting, dyspeptic phenomena.

A method for treating peptic ulcer of the stomach and duodenum is known in the conventional manner. At the same time, various antibiotics, antacids, beta-blockers are used.

However, the pharmacological agents used, having a certain therapeutic effect, have a number of disadvantages:

- they act only on certain parts of the pathogenesis of peptic ulcer and therefore there is a need to use a combination of different medications;

- often side effects of medications, especially when using many drugs (hypomotor dyskinesia of the intestine, complications of the liver, kidneys, central nervous system);

- Long term of treatment and high cost of drugs;

- insufficient antibacterial effect;

- low efficiency in elderly patients due to a change in reactivity, expressed atrophic and degenerative changes in the mucosa of the gastroduodenal zone (V.Vasilenko et al., Ulcer, M., Medicine, 1987, p.286, P.Derkachev. Treatment of chronic gastroduodenal ulcers associated with Helicobacter pylori, Candidate of Medicine, M., 1993).

The history of medical application of ozone is calculated from the beginning of the 20th century. Ozone-allotropic modification of oxygen. The ozone molecule contains three oxygen atoms and has two free valence groups, due to which it actively enters into various reactions and is one of the most powerful oxidants.

Possessing high reactogenic ability, ozone actively reacts with various biological objects, including cell structures. Due to the tight packing of lipids and proteins in biomembranes, it is the plasma membranes that play the role of the main target when ozone acts on the cell. Ozone is actively involved in the processes of lipid peroxidation, the feedback type stimulates these reactions. Under the influence of ozone in the tissues are restored adenosine triphosphate, adenosine diphosphate and adenosine monophosphate.

In humans and animals, ozone affects the immune system. After ozonotherapy, the initially increased amount of serum immunoglobulins of classes A, M, G is reduced.

To treat peptic ulcer of the stomach and duodenum, drink ozonized distilled water of 250 ml once a day and intravenously drip ozonated isotonic sodium chloride solution three times a day, every other day. Patients receive additional antiulcer treatment. When using ozone as a monotherapy, Helicobacter pylori disappeared only in 1 patient out of 150 (VA Maksimov et al., Ozone use in the treatment of peptic ulcer of the stomach and duodenum., Russian Journal of Gastroenterology., 1997, N 7, p.50- 53). The disadvantages of the method include multiple intravenous infusions of ozonized solutions, the absence of epithelialization of ulcers against the background of monotherapy with ozone and the preservation of H. Pylori.

With the local treatment of gastric and duodenal ulcers through the endoscope, washing of the ulcer defect with 96% alcohol is used, and the oiling of the sea buckthorn or rosehip oil.

As the closest analogue, a method has been adopted for the treatment of gastric and duodenal ulcers, including the application of sea buckthorn or dogrose oil to ulcer during gastroduodenoscopy (VM Bujanov et al., Medical endoscopy of gastroduodenal ulcers, Stavropol, 1986, p.53).

However, the known method has a number of significant drawbacks. This method does not affect Helicobacter pylori, does not have anti-inflammatory action, does not cause the formation of granulation tissue. Therefore, such gastroscopies do not have a therapeutic nature. Improvement occurs only if this treatment is performed against the background of antiulcer conservative therapy.

Ozonid oil, produced by the company Medozon, is a solution of ozonides of unsaturated carboxylic acids (natural origin) in oil. It is used for the treatment of skin diseases, long-term non-healing purulent wounds, trophic ulcers, burns, stomatitis, acute inflammatory diseases of the ear, throat and nose (VAMaksimov et al., Ozonotherapy., Smolensk, 1998). For treatment of stomach and duodenal ulcers is not used.

The mechanism of the therapeutic action of Ozonid oil is associated with its analgetic, anti-inflammatory and antiallergic effect; It has antiviral and fungicidal properties, stimulates reparative processes and local immunity, promotes the rapid cleansing of ulcers from necrotic masses, improves microcirculation. This is due to the fact that organic compounds containing double bonds that have different lipid components of tissues are especially sensitive to ozone. After ozonotherapy, there is a decrease in the number of phospholipids, triglycerides, free fatty acids. Thus, in tissues the content of those fatty acids that are most actively used as an energy substrate increases, the metabolic activity of polymorphonuclear neutrophils increases, and their antimicrobial activity increases.

The technical result of the proposed method is simultaneously protection of the ulcer area from the damaging effect of the acid-peptic gastric juice factor, suppression of Helicobacterial flora, stimulation of the reparative capacity of gastroduodenal tissues. The technical result is achieved due to the action on the ulcerative defect locally with a means possessing the properties of multicomponent influence on various pathogenetic components of the disease (Ozonid oil).

The method is carried out as follows. The patient under local anesthesia is injected with a gastroscopy into the stomach. Through the biopsy channel of the endoscope, a polyvinylchloride catheter is inserted, which is removed 1-2 cm from the canal and led to an ulcer. To the outer end of the catheter, connect a syringe with 3 ml of Ozonide oil, which is applied to the ulcer. The procedure is repeated the day before the formation of a red scar. On average, 3-6 procedures are required.

The method was clinically tested at the Department of Endoscopy of the Russian Medical Academy of Postgraduate Education on the basis of the Hospital. SP Botkin for 30 patients with gastric ulcer and duodenal ulcer. Of these, between the ages of 20 and 63, there were 28 males and 2 females. Duration of the disease from 1 year to 30 years. In 3 patients ulcers were localized in the stomach, in 27 patients in the bulb of the duodenum. The degree of dissemination of the gastric mucosa Hp was estimated as expressed in all patients. The treatment period averaged from 3 to 6 injections every other day, i.e. 10 days. At the same time, 27 patients received ambulatory treatment, 3 - permanently.

Results. Patients were observed after treatment for 6-8 months. Under the influence of intragastric administration of Ozonid oil after the first session, all pain patients completely stopped pain syndrome, appetite improved, disappeared phenomena disappeared. The ulcer was completely epithelized after 3-6 sessions with the formation of a tender scar without deformation of the organ wall and without narrowing its lumen. By the time of healing of the duodenal ulcer Hp, none of the patients showed up. In patients with gastric ulcers, the degree of dissemination of the mucosa was poorly expressed. To confirm the advantages of the proposed method, compared to the known, we give a comparison table.

Thus, as can be seen from the table, with the treatment method we propose, 96,6% of the patients recovered, the improvement - in 3,4%. Whereas with the known method, no patient fully recovered, and improvement was noted in 60% of patients. It is particularly advisable to use this method in patients with a recurring peptic ulcer of the stomach and duodenum complicated by bleeding, since the period of remission is significantly prolonged. In 29 patients treated with the proposed method, there were no relapses, and the period of remission lasts 6-8 months. In 1 patient, the stomach ulcer recurred 2 months after treatment.

The terms of treatment are reduced from 1-1.5 months to 6-12 days. Treatment can be carried out on an outpatient basis.

Example 1

Patient P., 58 years old, received complaints with pain in the epigastric region, heartburn, dyspeptic phenomena. She considers herself to be sick for 30 years. Annual spring and autumn exacerbations of peptic ulcer. The present exacerbation is within 1 week. Under local anesthesia, a gastroduodenoscopy was performed in which an ulcer was found on the back wall of a sharply deformed bulb of the duodenum 0.8 cm in diameter, with a deep bottom covered with fibrinous coating, and marked swelling and hyperemia of the mucosa around the ulcer. A biopsy is taken from the edge of the ulcer and from the antrum of the stomach. In the biopsy specimens of antrum, expressed dissemination of Hp. Morphological study of biopsy material taken from the edges of the ulcer showed the presence of conglomerates of cellular detritus with leukocyte and plasma infiltration of the mucosa, significant disturbances of microcirculation. Immunomorphological study revealed a decrease in the number of plasma cells, a distinct increase in immunoglobulin A (SigA). The applique was applied to the ulcer with 3 ml of Ozonid oil. After the first treatment, the pains disappeared. The treatment was conducted every other day, only 4 sessions per course of treatment. Recovery came in 8 days. With a control gastroduodenoscopy, a bright red stellate scar can be seen on the spot of the ulcer, with convergence of the folds of the mucosa to it. Mucous membrane around pink. A repeated biopsy was performed from the antral part of the stomach and from the rumen. In the biopsy specimens antrum Hp absent. In the morphological study of biopsy material from the edges of the ulcer, restoration of the structure of the duodenal mucosa and microcirculation, the presence of plasma cells, lymphocytes and fibroblasts was noted. SigA values ​​are within normal limits. Recurrence of the ulcer was not observed within 8 months.

Example 2

The patient S., 63 years old, turned out-ambulant with complaints of pain in the epigastric region, black stools, heartburn. It suffers from peptic ulcer disease for 15 years with annual seasonal exacerbations. The present exacerbation is within 25 days. Under local anesthesia, a gastroscopy was performed, at which a 1.3x0.7 cm ulcer was found on a small curvature in the middle third of the body of the stomach with a blood clot in the center, the mucosa around it is brightly hyperemic, edematous. The applique was applied to the ulcer with 3 ml of Ozonid oil. The treatment was conducted every other day, only 4 sessions per course of treatment. Recovery came in 8 days. Remission lasts 6 months.

Thus, the proposed method makes it possible to achieve a radical cure of peptic ulcer without the use of complex antiulcer therapy, and consequently, this significantly reduces the cost of treatment.

CLAIM

The method of treatment of gastric and duodenal ulcers, including intragastric application on the ulcer drug, characterized in that as a therapeutic drug, use the oil "Ozonide" in an amount of 3 ml every other day.

print version
Date of publication 29.03.2007gg

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