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INVENTION
Russian Federation Patent RU2257905
AGENT FOR THE TREATMENT OF PATIENTS WITH CHRONIC CHOLECYSTITIS
Name of the inventor: Lazebnyk Leonid Borisovich (RU); Kasyanenko Valentina (RU); Yulia Orlova N. (RU); Trubitsyna Irina E. (RU); Lychkova Alla Eduardovna
The name of the patentee: Lazebnyk Leonid Borisovich (RU); Kasyanenko Valentina (RU); Yulia Orlova N. (RU); Trubitsyna Irina E. (RU); Lychkova Alla Eduardovna
Address for correspondence: 129343, Moscow, ul. Amundsen, 11, building 1, kv.53, AE Lychkova
Starting date of the patent: 2003.10.31
The invention relates to medicine, namely to gastroenterology, and relates to the treatment of chronic cholecystitis. For this purpose, administered orally 35-51% honey water solution having a temperature of 13-43 ° C. This method enhances the effectiveness of treatment by improving the contractile function of the gallbladder while avoiding complications.
DESCRIPTION OF THE INVENTION
The invention relates to medicine, namely to treatment of extrahepatic biliary tract disease, and can be used as a remedy for chronic cholecystitis.
A method of treating cholecystitis, including cholecystectomy, taken as an analogue [1].
Known agent for the treatment of gallstone disease [2], taken as a prototype. The tool includes a bio-stimulating blend of aloe juice and honey, dandelion juice mother and stepmother, and a mixture of juice of black radish, beet and horseradish vodka and honey.
However, this tool is a complex, multi-component and can lead to an exacerbation of diseases of the gastrointestinal tract, as biostimulating mixture contains sharp, potent ingredients (black radish, horseradish and vodka).
The aim of the present invention is to increase efficiency of treatment by improving contractile function of the gallbladder while avoiding complications.
The technical result is achieved in that the medicament is used as an aqueous solution of 35-51% of honey at temperatures 13-43 ° C, and the investigation of the effect of honey solution is carried out after 40-60 min after administration honey solution.
The tool is applied as follows.
When a patient find out the presence of complaints characteristic of the disease cholecystitis - a feeling of bitterness in the mouth, mild pain or a feeling of heaviness in the right hypochondrium, the presence of nausea and vomiting. Celebrating involuntary tension of the abdominal muscles on the right, the presence of pain at the height of inspiration on deep palpation of the liver. Carry out a study of bile by the chromatic fractional duodenal intubation with staining portions gallbladder bile (portion B) in blue color with subsequent measurement of its volume.
Microscopic studies reveal accumulation of bile columnar epithelial cells, mucus, crystals of calcium bilirubinate cholesterol.
Ultrasound examination of the gallbladder determine the size and condition of the bladder wall, the presence in it of stones, and the contractility of the gallbladder before and after administration of the aqueous solution of honey.
In the study of blood serum level of amylase in patients with cholecystitis - 50-60 or more units, neutrophils - 9-11 x 10 9 / L, the content of cholinesterase - 0,22 ± 0,02 mmol / l / 30 min, the level of acetylcholine -0 64 ± 0,03 mmol / l.
Then apply the remedy in the form of an aqueous 35-51% solution of honey at a temperature of 13-43 ° in the amount of 1/4 cup, and after 40-60 min after administration of honey solution is carried out investigation of the effect of honey solution on the contractile function of the gallbladder with chronic cholecystitis.
According to the ultrasound determined volume of the gallbladder before and after taking the honey solution. Contractile function of the gallbladder in response to the introduction of honey solution is defined as the difference between the volume of the gallbladder before and after taking the honey solution. In identifying satisfactory contractile capacity, the gallbladder is reduced by 34 ± 3,5%, which is considered an indication for the treatment of chronic cholecystitis using apitherapy.
Then spend apitherapy patients within 2.5-3 weeks (without antibiotic therapy), which allows to bring patients in clinical and laboratory remission. Disappears pain, normal contractile function of the gallbladder, decreased pain on palpation of the right hypochondrium study.
When ultrasound control point reduction in the thickness of the gallbladder wall, restoring the contractility of the gallbladder with a load of lipids and cholesterol.
In the control study, serum amylase level is 30-40 units., Leukocytes 7-8.5 × 10 9 / L, cholinesterase content 0,35 ± 0,03 mmol / l / 30 min, the level of acetylcholine 0.71 ± 0 04 mmol / l.
The method is confirmed by the following examples.
Example 1.
The patient in the K-43 years, when you receive complains of nausea and a feeling of heaviness in the right hypochondrium, palpation, tenderness in the right upper quadrant. The fractional duodenal intubation with staining portions gallbladder bile (portion B) blue showed that the volume of the gallbladder bile is 22 ml. Microscopic studies reveal accumulation of bile columnar epithelial cells, mucus, crystals of calcium bilirubinate cholesterol.
Ultrasonography: Bubble contours equal, without constrictions, the volume is 25 cubic meters. cm. The wall of the bladder is thickened. Contractile ability of the gallbladder is reduced.
In the study the serum: amylase 50 U, leukocytes 9 × 10 9 / L, cholinesterase content 0.20 mmol / l / 30 min, the level of acetylcholine 0.61 mmol / l..
Then use the claimed means in the form of an aqueous 35% honey solution at 43 ° C in a volume of 1/4 cup and 40 minutes after administration of the solution is carried out a study of honey honey solution effect on the contractile function of the gallbladder in chronic cholecystitis. Under the influence of the contractile function of the gallbladder and the proposed drug has improved its volume decreased by 31%.
The results obtained with the use of honey is considered an indication for subsequent apitherapy given patient.
Then spend apitherapy patient for 2.5 weeks without antibiotic therapy that helped bring it to clinical and laboratory remission. Pain disappeared, returned to normal contractile function of the gallbladder, decreased pain on palpation of the right hypochondrium study.
When ultrasound control point reduction in the thickness of the gallbladder wall, restoring the contractility of the gallbladder.
In the control study serum: amylase - 30 units, leukocytes - 7 x 10 9 / L, cholinesterase content - 0.32 mmol / l / 30 min, the level of acetylcholine - 0.70 mmol / l..
Example 2.
Patient C to 45 years admitted with complaints of bitterness in the mouth, mild pain in the right upper quadrant, especially after a fatty meal. On examination, involuntary tension of the abdominal muscles on the right, the presence of pain at the height of inspiration on deep palpation of the liver. The fractional duodenal intubation reveals gallbladder bile volume of 18 ml.
Microscopic studies reveal accumulation of bile columnar epithelial cells, mucus, cholesterol.
If ultrasound bladder smooth contours, overstretched bladder, there is a constriction and calculus size 0.8 × 1 cm. Contractile ability of the gallbladder is reduced.
Serum amylase level was 54 U., Neutrophilia of 10.5 x 10 9 / L, cholinesterase content 0.23 mmol / l / 30 min, the level of acetylcholine 0.64 mmol / l.
Then use the claimed means in the form of an aqueous 45% solution of honey in volume% glass at a temperature of 37 ° C, and 50 min after administration of the solution is carried out a study of honey honey solution effect on the contractile function of the gall bladder. In this patient under the influence of the proposed drug found satisfactory contractility of the gall bladder - it decreased by 35%. Satisfactory contractile function of the gallbladder in response to the solution of honey was the indication for subsequent patient apitherapy.
Then spend apitherapy patients for 20 days, which will bring the patient in clinical and laboratory remission. Gone is the feeling of bitterness in the mouth, pain in the right upper quadrant, normalized contractile function of the gallbladder.
Serum amylase level was 35 U., Leukocytes, 8.0 × 10 9 / L, the level of cholinesterase 0.36 mmol / l / 30 min, acetylcholine content of 0.73 mmol / l.
When the control ultrasound marked reduction in the thickness of the gallbladder wall, restoring the contractility of the gallbladder.
Example 3.
Patient N Islands, 48 years old, complains of a feeling of heaviness in the right hypochondrium. In the study noted the involuntary tension of the abdominal muscles on the right. The volume of the gallbladder bile with fractional duodenal sounding 28 ml.
Microscopic bile examination reveals mucus bilirubinate crystals of calcium, cholesterol.
Ultrasonography - gallbladder contours equal, without constrictions, atonic bladder.
In the study the serum: 60 amylase units, neutrophilia 11 x 10 9 / L, cholinesterase content 0.25 mmol / l / 30 min, the level of acetylcholine 0.67 mmol / l..
Then use the claimed means in the form of an aqueous 51% honey solution at 13 ° C in a volume of 1/4 cup and 60 minutes after administration of the solution is carried out a study of honey honey solution effect on the contractile function of the gall bladder. The patient was found satisfactory contractility of the gallbladder (37%).
The results obtained with the use of honey is considered an indication for subsequent apitherapy this patient.
Then spend apitherapy sick for 3 weeks, which allows you to view the patient in the clinical and laboratory remission. Gone is the feeling of heaviness in the right hypochondrium and tension of the abdominal muscles on the right.
In the control study serum: amylase units 40, 7 Neutrophils 10 9 / l, cholinesterase content of 0.38 mmol / l / 30 min, the level of acetylcholine 0.75 mmol / l.
When ultrasound control point reduction in the thickness of the gallbladder wall, restoring the contractility of the gallbladder.
According to the proposed method has been successfully treated 30 patients (10 men and 20 women) with chronic cholecystitis, a mean age of 45,6 ± 2,2 g in this group of patients had a satisfactory contractility of the gallbladder after apitherapy. Clinical and laboratory remission of chronic cholecystitis was accompanied by a simultaneous favorable impact on the condition of the mucous membrane of the gastrointestinal tract.
INFORMATION SOURCES
1. Manual medicine. Diagnosis and therapy. R.Berkou (eds). v.1. M .: Mir, 1997, s.631-633.
2. RF Patent №92011702 (1995).
CLAIM
The use of 35-51% aqueous solution of honey with temperature 13-43 ° C as a treatment for patients with chronic cholecystitis with decreased contractile function of the gallbladder.
print version
Publication date 28.01.2007gg
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