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INVENTION
Russian Federation Patent RU2200594

METHOD OF TREATMENT atypical forms of psoriasis

METHOD OF TREATMENT atypical forms of psoriasis

Name of the inventor: Tereshin KY
The name of the patentee: Far Eastern State Medical University
Address for correspondence: 680000, Khabarovsk, ul. M-Amur, 35, DVGMU, OIC
Starting date of the patent: 2000.07.10

The invention relates to medicine, in dermatology and can be used for treatment of atypical forms of psoriasis. Spend epithalamin intramuscular injection of 1 ml daily for 10-15 days. In the following 10 daily treatments administered by Epithalamin binazalnaya electrophoresis of 10 mg of the positive electrode. A second electrode is placed on the occipital region. Locally on psoriatic plaques bandage with nitrogen-silicon mineral water for 1-2 hours, 1-2 times a day, every day, for 20-25 days. The method improves the efficiency of the treatment of atypical forms of psoriasis.

DESCRIPTION OF THE INVENTION

The invention relates to medicine, in particular for dermatology.

In recent years, become increasingly register atypical forms of psoriasis, including exudative manifestations such as "eczema, psoriasis" occurring as allergic skin process. In patients with psoriasis revealed changes in the coagulating and immune systems, lipid and cholesterol metabolism, psycho-emotional and other areas, so acute in this current dermatosis may arise from various causes (mental and physical stress, injuries, exacerbation of chronic diseases, and others.) Without the influence of the seasonal factor and characteristic of psoriasis relapse mostly in the winter - in 60-75% of cases. Atypical forms of psoriasis and require non-standard approach to their treatment, since conventional methods in such cases are hardly effective, since they have a one-sided effect on some one disturbed link in the pathogenesis of psoriasis.

Hypothalamic brain system is the main regulatory system in the body through which the impact of external environmental factors affect the internal organs and systems. Stressful situations that reduce adaptive capacity of patients, particularly with a hereditary predisposition to dermatitis, lead to a breach of the regulatory impact of the central nervous system (CNS).

Object of the invention: to restore the consistency of the body's functional systems among themselves and with the external environment factors in patients with atypical form of psoriasis.

The closest analogue - protopipom - is the treatment of atypical forms of psoriasis by PUVA therapy hemosorption, Cytostome geeks. (Skripkin JK Skin and venereal disease. M .: Triad-X, 2000, p. 369-373).

But the disadvantages of these methods is the possible occurrence of serious complications (skin cancer hemodyscrasia), the need for special expensive and sophisticated equipment available only in institutions dermatological profile.

The proposed treatment of the present method provides an atypical form of psoriasis - with exudative manifestations reminiscent of the flow with the presence of psoriasis clinic eczematization, ie with ostrovospalitelnymi phenomena, erosive and moist areas (especially in the natural folds of the large) and the presence on the surface of the flake-crusts plaque, which is not typical for a typical psoriasis.

The purpose of the invention - increase the therapeutic efficacy of treatment of patients with atypical form of psoriasis, the reduction of complications, simplification of the process.

This object is achieved in that the first Epithalamin injected intramuscularly with 1 ml daily for 10-15 days, ostrovospalitelnuyu progressive stage, then in stage stationary-regressive in 10 ml binazalnaya electrophoresis with a positive pole (second electrode is placed on the occipital region or cervical-thoracic spine) in the amount of 10-15 procedures. Simultaneously carried externally vnekurortnoe silicon nitrogen-treated mineral water in the form of dressings for 1-1.5 hours two times a day (ostrovospalitelnuyu progressing step) for 1.5-2 hours and 1 time daily in the following days of treatment at a resolution exudative inflammation. General course lasts for 20-25 days. Appointment epithalamin binazalnaya in electrophoresis was performed for the purpose of direct injection in the neural structures of the brain regulating hypothalamic department patients, in addition, it takes into account the non-traumatic administration since in patients with psoriasis symptom expressed Kebnera (when the injury site of injections or skin irritation, new psoriatic elements).

The mechanism of action of nitrogen-silicon mineral water is its anti-inflammatory, vasoconstrictor effect (which is why this mineral water is the most effective for exudative inflammatory skin processes), hormone, desensitizing, absorbent with nitrogen immune complexes removing them from the lesions, "substitutionary" action the shortage of silicon in the pathological focus, strengthened by silicon walls of vessels in the skin and thus, reduces vascular permeability for exudate coming from the bloodstream into the tissues.

30 patients with exudative form of psoriasis at the age of 20 to 56 years of age and disease duration of 10 to 25 years were treated by the inventive method. Introduction epithalamin binazalnaya was possible only after decrease ostrovospalitelnyh phenomena and resolution of psoriatic elements in the occipital or cervical-thoracic spine (since it is impossible to place an electrode on the surface of weeping erosive). External treatment of wet-drying up bandages (in the form of lotions) with nitrogen-silicon mineral water carried the sick in the morning (9-10 hours) and night (20-21 hours) time 1-1.5 hours daily until subsided exudative inflammation and then once in the morning for 1.5-2 hours. Treatment of patients with atypical form of psoriasis take 18-25 days, on average 20-22 days instead of 30-35 days with conventional methods of treatment.

The advantage of the proposed method is:

- The possibility of treating atypical exudative form of psoriasis;

- Recovery of the mitotic (proliferative) activity of the epidermis;

- Removal of the "fixed" immune complex on the surface of the lesions;

- The removal of "allergic background" due to hormone-correcting, desensitizing and anti-inflammatory action of silicon.

Example 1. Patient G. 50 years. Bohlen psoriasis for 20 years. The first years after the onset of exacerbation of dermatosis were seasonal in nature, in the winter, with typical clinical manifestations on the skin of the trunk, upper and lower extremities. The patient was repeatedly treated in inpatient and outpatient settings, getting a spa treatment. After active treatment, carried out the sick within a few years, every year (PUVA therapy, the next year - hemosorbtion, cytostatics in the event of erythroderma, hormone therapy) in this patient there was atypical for a dermatosis with the presence of exudative manifestations and non-seasonal exacerbations arising from a variety of stressors .

If the next exacerbation of the skin process a patient were treated within 10 days of intramuscular injections epithalamin 1 ml.

At the same time externally applied dressings with nitrogen-silicon mineral water for 1-1.5 hours daily, 2 times a day. After calming down ostrovospalitelnyh exudative phenomena epithalamin treatment is started by introducing 10 mg binazalnaya by electrophoresis with the positive pole and the imposition of a second electrode on the occipital region of 15 procedures. Local: continued use of dressings with mineral water for 1.5 hours, 1 times a day. Cutaneous process is completely resolved within 25 days. Monitoring of patients after treatment by this method was carried out during the year - non-seasonal exacerbation was observed.

Example 2. Patient B. 40 years. Sick of psoriasis with 16 years of age. It notes the emergence of an exacerbation of the skin process a year, in spring and autumn, in connection with which repeatedly received treatment in inpatient and outpatient settings. Since 1994, it was treated with plasmapheresis, hemosorption after which aggravation occurred after nerve trauma. On the skin of the trunk and limbs were extensive lesions bright red color to the presence of scales, crusts, which were revealed after removal weeping erosive lesion sites. It was noted, and the deterioration of the general condition, the presence of low grade heat. The diagnosis: a common exudative psoriasis, lenticular, patchy form, unspecified type.

Epithalamin therapy started 1 ml intramuscularly daily while treating inflammatory outer silicon nitrogen-mineral water in the form of lotions (under occlusion) for 1-1.5 hours two times a day - morning and evening. After 14 days ostrovovspalitelnye phenomenon resolved, the general condition of the patient to normal. There was an active resolution of psoriatic elements. Continued treatment epithalamin binazalnaya administration of 10 mg with a positive pole and applying a second electrode on the occipital region for 10 days. Outwardly continued bezmazevoe treatment dressings with nitrogen-silicon water for 1.5 hours, and within 10 days. The total course of treatment was 24 days. Elements of the rash completely uplostilis, pale, and the patient was discharged with clinical recovery.

CLAIM

1. A method for treating atypical forms of psoriasis, characterized in that initially carried epithalamin intramuscular injection of 1 ml daily for 10-15 days, following 10 daily treatments administered Epithalamin binazalnaya by electrophoresis on 10 mg of the positive electrode, the second electrode is placed on the occipital region.

2. The method of claim. 1, characterized in that the topically applied on the psoriatic plaques bandage with nitrogen-silicon mineral water for 1-2 hours, 1-2 times a day, daily for 20-25 days.

print version
Publication date 06.01.2007gg