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INVENTION
Russian Federation Patent RU2204936
METHOD FOR DETERMINING skin blood flow
Name of the inventor: Elkin VD .; Datskovsky YS
The name of the patentee: Perm State Medical Academy
Address for correspondence: 614990, Perm, ul. Kuibyshev, 39, PGMA, patent department
Starting date of the patent: 1998.11.23
The invention relates to medicine, dermatology. Measured blood flow velocity and volume of blood filling the area of skin in relation to an ECG. Skin blood flow is determined by the formula Kubitschek. When V = 0,136-0,718 ml per 1 heartbeat define normal blood flow. With average less than 0,136 and more than 0,718 - changed. The method improves the measurement accuracy, detect the presence of autonomic disorders and make adjustments to the treatment.
DESCRIPTION OF THE INVENTION
The invention relates to medicine, namely to dermatology, and can be used for the diagnosis of vascular diseases of the skin and monitoring the effectiveness of treatment.
Known method for determining blood flow through a unique prototype reopletizmografa RPG2-02. Method is based on the resistance change of living tissue a high frequency current (g Cardiology -.. M .: Med 1977, 7, s.85-90.).
Disadvantages: this device and any modifications it is impossible to differentiate the level of skin blood flow, since the method allows to determine only the total (integral) of the skin blood circulation, subcutaneous fat, muscles.
The invention is directed to the solution of the problem: increasing the measurement accuracy, the achievement is the ability to measure skin blood flow.
This object is achieved by measuring blood flow velocity and volume of blood supply to an area of skin in relation to an ECG.
Skin blood flow is determined by the formula Kubicek:
V = 0,9 × 150 × 2 l / z 2× A d B T and,
where V - the amount of blood flowing in the test area of skin 1 heart beat, ml;
0.9 - correction factor due to the superposition of the electrodes;
150 - constant specific resistance of the blood;
l - the distance between the electrodes, see;
z - the base impedance, Ohm;
A d - the amplitude of the differential curve, Ohm / s;
T and - during the blood expulsion for 1 cardiac systole, with,
and when the value of V = 0,136-0,718 define normal blood flow, and at 0,136> V> 0,718 - changed.
The process is performed as follows: the patient is applied on the electrodes of the study area of the skin, for example, on the forearm and at the same time - electrodes for ECG. With the help of the device for the determination of skin blood flow, such as the skin tester opredeleyayut blood flow velocity and volume of blood supply of the skin. The data is calculated by the following formula:
V = 0,9 × 150 × 2 l / z 2× A d B T and,
where V - the amount of blood flowing in the test area of skin 1 heart beat, ml;
0.9 - correction factor due to the superposition of the electrodes;
150 - constant specific resistance of the blood;
l - the distance between the electrodes, see;
z - the base impedance, Ohm;
A d - the amplitude of the differential curve, Ohm / s;
T and - during the blood expulsion for 1 cardiac systole, with,
and V = 0,136-0,718 ml for 1 heart beat define normal blood flow at rates below 0,136> V> 0,718 - changed.
These numerical values were obtained as follows. It examined a group of 20 healthy individuals aged 20-40 years. The amount of blood in the measured area of the skin for 1 heartbeat ranged 0,281-0,599 ml. The average value (M 1) amounted to 0.427 ml; the average error (m 1) = 0.022; sigma (d) = 0,097. According to the laws of statistics corridor normal values of M 1± 3 d, then there is 0,427 ± 0,291, or from 0,136 to 0,718.
A method for determining skin blood flow allows to take into account the dynamics of the functional state of the skin blood vessels in response to some stimuli, such as exercise. These 20 healthy load submaximal contraction was brush pears sphygmomanometer 20 times for 1 min, followed by measurement of blood flow velocity and volume. The figures are as follows: M 2 = 0,318, m 2= 0,04, d = 0,063. These data indicate an authentic shift: 
Examples of specific performance.
Determination of blood flow to the forearm skin produced by the method.
Example 1. Patient K and 38 years old, was admitted to the hospital with a diagnosis of chronic eczema. Before treatment, V 1 = 0.08; in the complex treatment (3 weeks) index V 2 = 0.027; normalized by the end of the 5-week course of therapy, the blood flow rate - V 3 = 0.48.
Example 2. Patient P-about 23 years, was admitted to the hospital with a diagnosis of atopic atopic dermatitis. Before treatment V 1 = 0.03, indicating a severe deficiency of blood circulation of the skin. After 2 weeks in the combined treatment, including physical therapy and vascular drugs, V 2 = 0.11; a month later (after the course) V 3 = 0.28 (normalized level). The patient is recommended to continue treatment as an outpatient. Another study skin blood flow after 1.5 months testified to the full normalization of the skin blood flow: V 4 = 0.42.
Example 3. Patient Sch-in 29 years, was admitted to the hospital with a diagnosis of psoriasis. In the first study, V 1 = 1.05. The patient revealed persistent hypotension. In the complex treatment of physiotherapy and adaptogen were introduced. After 3 weeks of treatment, V 2 = 0.701. The patient was recommended systematic physical therapy sessions and balneotherapy.
EXAMPLE 4-a, healthy, 32 year. Donor. V = 0,49 (normal skin blood flow).
Positive effect
Determination of skin blood flow at the level of dermatologic patients allows to objectively assess the state of blood circulation in the skin, reveal the presence of autonomic disorders and prescribe additional pathogenetic therapy. Research in skin blood flow dynamics allow to make timely adjustments to the treatment process.
CLAIM
A method for determining the blood flow of the skin by measuring the volume of blood filling the test skin area, characterized in that in addition to determining the volume flow rate in comparison with the cardiac cycle, and blood flow was calculated by the formula
V = 0,9 × 150 Part 1 of 2 / z 2× A d B T and,
where V - the amount of blood flowing in the test area of skin 1 heart beat, ml;
0.9 - correction factor due to the superposition of the electrodes;
150 - constant specific resistance of the blood;
1 - the distance between the electrodes in cm;
z - the base impedance, Ohm;
A d - the amplitude of the differential curve, m / s;
T and - during the blood expulsion for 1 cardiac systole, with,
and V = 0,136-0,718 define normal blood flow, and at 0,136> V> 0,718 - changed.
print version
Publication date 01.04.2007gg
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