| section Home
Production, Amateur Radio amateur Model aircraft, rocket- Useful, entertaining |
Stealth master
Electronics Physics Technologies invention |
space Mystery
Earth Mysteries Secrets of the Ocean Stealth section Map |
  |
| Use of material is permitted for reference (for websites - hyperlinks) | |||
Navigation: => |
Home / Products Patents / In the section of the catalog / back / |
|
INVENTION
Russian Federation Patent RU2154480
METHOD FOR THE TREATMENT OF PATIENTS WITH PSORIASIS IN COMBINATION WITH chronic opisthorchiasis
Name of the inventor: Khardikova SA .; Beloborodova EI .; Pesterev PN
The name of the patentee: Siberian State Medical University; Khardikova Svetlana A.; Beloborodov Elvira Ivanovna; Petro Pesterev
Address for correspondence: 634050, Tomsk, Moscow highway 2, SSMU, Intellectual Property Department, Zubareva NG
Starting date of the patent: 1999.11.01
The invention relates to medicine and can be used for the treatment of psoriasis in combination with chronic opistorhozom. On the first day of treatment praziquantel administered at 30 mg / kg, and the next day further dry extract of bark of aspen (Populus tremuloz) at a dose of 0.03 g / kg body weight two times a day after meals for a period of 5 days. The method allows to reduce the times 2 praziquantel dose due to its combination with the vegetable preparation. This reduces the number of complications in patients with associated pathology and improves the efficiency of de-worming.
DESCRIPTION OF THE INVENTION
The invention relates to medicine, dermatology, and methods for treating psoriasis in combination with chronic opistorhozom.
A method of treating patients with combined pathology using praziquantel, assigned to the usual dose of 60 mg / kg body weight at night in Scheme 3 doses with an interval of 4 hour. The effectiveness of deworming was 100%. However, this treatment of patients with psoriasis is a skin complication of the process in the form of the appearance of new lesions, especially in the first days after deworming, accompanied by itching, which required additional detoxification therapy, for example, gemodez, for 5 days (Belyalov IG "The course of psoriasis, a condition of the stomach and biliary system when combined with chronic opisthorchiasis ". Abstract of dissertation for the degree of candidate of medical Sciences. Tomsk, 1999).
New technical result - reducing the number of complications in high efficiency deworming achieved using a new method of treating psoriasis in combination with chronic opisthorchiasis, including deworming praziquantel in stationary psoriasis stages, with praziquantel administered at a dose of 30 mg / kg of body weight, and a day in addition appointed reception dry extract of bark of aspen (Populus tremuloz) at a dose of 0.03 g / kg body weight 2 times daily after meals for 5 days.
The process is carried out as follows:
Before entering the gastroenterology clinic for translation advanced stage psoriasis in a stationary patient ambulatory receives the following treatment: disintoxication therapy (sodium thiosulfate solution 30% of 10 ml / v N 10), antihistamines (Trex 1 tablet daily for 7 days), vitamins ( vitamin B1 1 ml / m N 10, vitamin B6 and 1 ml / m 10 N, 2 Aevitum 1 capsule twice a day 30 days), sedatives (sibazon 1 tablet at night 20 days). Outer: Unna cream.
and the patient undergoes physical examination (complete blood count, urinalysis, blood chemistry), liver ultrasound, duodenal intubation.
While in the duodenal bile eggs opistorhisov patient is sent for deworming in gastroenterology hospital EDO.
At the hospital the patient receives praziquantel at night scheme at a dose of 30 mg / kg of body weight in 3 divided doses with an interval of 4 hours (10 pm to 2 am, 6 am). After one day, the treatment continues dry aspen bark extract in dose of 0.03 g / kg two times a day after meals for a period of 5 days.
The chemical composition of aspen bark contains fenolglikozidy (salicin, Populina, salikortin, tremulatsin), tannins, organic acids (benzoic, malic), ascorbic acid, pectin, gums, fats and a small amount of essential oil. The dry extract of bark of aspen is obtained by 5-fold repercolation cortex aspen 70% ethanol at room temperature with the infusion period 8 hours, followed by removal of the extractant under vacuum at 50 o C and adjusting to a dry extract in a vacuum oven at 40 o C. Yield the desired product is 13.5%. The drug has a pronounced protivoopistorhoznoy activity, which is reflected in the index of intens - 79.3%. Protivoopistorhoznoe effect of the extract was studied on golden hamsters infected metatsirkariyami opistorhisov (Krasnov EA, Balasheva II, Lepekhin AV Bychkov NK, Dudko VV Saratikov AS n N 1695542 , 04.01.94, the). Later it was revealed a pronounced choleretic effect of the drug (Patent RF N 2126687 BI N 6 from 27.02.99 city).
The dry extract of bark aspen used, for example in tablet form, at a dose of 0.03 g / kg two times a day after meals for a period of 5 days.
Praziquantel - 2- (Cyclohexylcarbonyl) -1,2,3,6,7,11b-hexahydro-4H-pyrazino (2,1-a) isoquinolin-4on - white crystalline powder with a bitter taste. Quickly absorbed by ingestion. Peak plasma concentrations observed after 1-2 hours. Metabiliziruetsya and quickly displayed to 80% as a metabolite in the kidneys for 4 days while 90% is excreted in the first 24 hours.
The mechanism of action is important to increase his influence the permeability of cell membranes of parasites for calcium ions. The drug causes a reduction in the parasite musculature, passing in spastic paralysis. It is highly effective for the treatment of schistosomiasis and trematodozov. Assign inside for 1-2 days. Normally take a day to 25 mg / kg body weight 3 times or 30-40 mg / kg, 2 times. The drug provides a high therapeutic effect (100%). Product: tablets. (Mashkovskii MD Lekarstvennnye means -. M .: Medicine, 1993 m 2, with 448...).
The dose of praziquantel has been reduced by 2 times against commonly used due to the combination with anthelmintic drugs of plant origin. Doses and consistency of the drug are chosen based on clinical observations of this category of patients. After the course of treatment carried out a control probe, according to which measured the effectiveness of deworming. The course of the dry extract of the bark of aspen (5 days) is necessary and sufficient for the treatment of these patients. During the de-worming during the term of less than 5 days reduced the effectiveness of de-worming, and lengthening of the course of treatment for more than 5 days leads to additional undesirable side effects for patients with psoriasis. In the daytime drug is given for the convenience of monitoring of patients in 2 divided doses - to increase the concentration of herbal drug to more effectively carry out deworming. Heading dose of 0.3 g / kg body weight is necessary and sufficient for clinical observation for the effective de-worming, in combination with praziquantel.
Example:
Patient LG Martynov, 21 years old, was admitted to the gastroenterology department of OKB with the diagnosis: Chronic opistorhoz. Chronic cholecystitis nekalkulezny in the stage of moderate exacerbations. Biliary dyskinesia of hypokinetic type. The accompanying diagnosis: Psoriasis, guttate, plaque, fixed stage, common, autumn and winter.
On admission he complained of heaviness in the right upper quadrant, a constant bitter taste in the mouth, nausea, decreased appetite.
From history revealed that the patient suffers from psoriasis for 10 years. Last aggravation appeared a month ago. The following treatment: detoxification therapy (sodium thiosulfate, 30%, 10 ml / in N 10), antihistamines (Trex 1 tablet daily for 7 days), vitamins (Aevitum 1 capsule 2 times daily for 30 days), sedatives (sibazon 1 tablet at night 20 days). Outer: Unna cream.
The last 2 years began to disturb the gravity in the right upper quadrant, intermittent pain in this area, fatty food intolerance, nausea.
A outpatient physical examination, ultrasound, duodenal intubation.
The general analysis of blood eosinophilia up to 5%. The general analysis of urine - without pathologic changes. Biochemical blood test within normal limits.
According minutirovannogo chromatic duodenal probing revealed gallbladder dyskinesia of hypokinetic type: gallbladder bile flowed in large volume to 100 ml (at a rate of 60 ml) and its expiration time has been lengthened to 45 minutes (normally 21 minutes). Revealed hypotension, sphincter of Oddi.
When bile microscopy revealed opisthorchis eggs (3-4 in sight).
According to the ultrasound volume of gallbladder was significantly increased and reached 80 cm 3 (at a rate of 40-60 cm 3).
In the transition process of the skin to the stationary stage was admitted to hospital EDO for chronic opisthorchiasis.
OBJECTIVE: asthenic physique. The skin in the area of the scalp, torso, elbows and knees papules pink and brown, coalescing into plaques, covered by silvery-white scales. Psoriatic triad of positive (stearin spot phenomenon, the phenomenon of psoriatic film, the phenomenon of the point of bleeding). Language coated with white bloom. The lungs and heart without pathology. The abdomen was soft, with tenderness in the right upper quadrant is moderately painful. Positive symptoms Kera and Murphy.
For the treatment of chronic and opisthorchiasis gipomotornoy gallbladder dyskinesia combined method of treatment has been appointed: praziquantel at a dose of 30 mg / kg, and in a day of dry aspen bark extract at a dose of 0.03 g / kg body weight 2 times daily after meals for 5 days .
Treatment of the patient is well tolerated. After deworming praziquantel side effects it was noted. The emergence of new skin rash, itching was observed on Day 3 the application of a dry extract of the bark of aspen vanished feeling of heaviness in the right upper quadrant, the bitterness in the mouth, by the end of the treatment did not disturb the feeling of nausea, appetite improved. control duodenal intubation, ultrasound performed after treatment of chronic opisthorchiasis. According to the fractional volume of duodenal intubation gallbladder bile and its normalized flow time and totaled 60 mL (at a rate of 60 ml) and 20 minutes (21 minutes normally). Violations in the activities of the sphincter apparatus have been identified. When bile microscopy revealed opisthorchis single egg. According to the ultrasound volume of gallbladder was 54 cm 3, which is the norm. Within a week of the treatment of psoriasis manifestations was reached regression. One month after treatment the patient noted the good state of health, complaints from the abdomen did not show disappeared nausea, appetite returned to normal. A repeated duodenal intubation. When bile microscopy eggs opisthorchis been identified. Skin was in the process of regression stage.
Combined method treated 8 patients with psoriasis in combination with chronic opisthorchiasis. Side effects from the skin, the gastrointestinal tract in the treatment of this method have been reported. The effectiveness of deworming was 90%.
Thus, the proposed method allows the authors to treat patients with comorbidity using optimally matched combination of high-performance anthelmintic drug with anthelmintic drugs of plant origin, obtained from local raw materials. This made it possible to halve the dose of a highly efficient, but also highly toxic and praziquantel more gently with a sufficiently high efficiency (90%) carry out the treatment of patients with psoriasis.
CLAIM
A method of treating psoriasis in combination with chronic opisthorchiasis, is to conduct deworming praziquantel during the stationary stage of the process, characterized in that prescribed in the first day of treatment with praziquantel at a dose of 30 mg / kg, and a day later appoint more dry extract of aspen bark (Populus tremuloz ) at a dose of 0.03 g / kg body weight two times a day after meals for a period of 5 days.
print version
Publication date 01.04.2007gg
Comments
Commenting, keep in mind that the content and the tone of your messages can hurt the feelings of real people, show respect and tolerance to his interlocutors, even if you do not share their opinion, your behavior in terms of freedom of speech and anonymity offered by the Internet, is changing not only virtual, but real world. All comments are hidden from the index, spam control.