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INVENTION
Russian Federation Patent RU2154458

METHOD FOR THE TREATMENT OF PSORIASIS

METHOD FOR THE TREATMENT OF PSORIASIS

Name of the inventor: Khairulin F.YA .; Virnik VL .; Bukhtiyarov RS
The name of the patentee: Russian medical company; Khairulin Farid Yarulovich; Virnik Victor Leopoldovich; Bukhtiyarov Roman Semenovich
Address for correspondence: 350049, Krasnodar, ul. Sevastopol 3 kv.36, Khairulin FY
Starting date of the patent: 1997.05.06

The invention relates to medicine, dermatology. Spend drug effects and speleotherapy. Speleotherapy carried out in a chamber artificial microclimate. Sodium chloride aerosol is used, the density of 3 - 5 mg / m3, particle size 3 - 5 mm. The method shortens treatment time.

DESCRIPTION OF THE INVENTION

The invention relates to medicine, namely to dermatology, and can be used in the treatment of psoriasis, various forms and stages.

The problem of psoriasis treatment is becoming increasingly important. This is due to its prevalence (7-10% of all skin diseases), duration of course, a tendency to recur.

The pathogenesis of the disease remains unclear until the end. The prerequisites are in methods for treating disorders in the body of the patient. The presence of psoriasis in a patient, usually accompanied by systemic disorders: violation of the functional state of the gastrointestinal tract, osteo-articular apparatus, the kidneys, the hepatobiliary system, imbalance in the immune and endocrine systems. A significant role played by genetic factors. With regard to the etiology of psoriasis, it is mainly isolated neurogenic, autoimmune, genetic, viral theory.

The complexity of the problem gave rise to a significant number of ways to treat psoriasis based on the nature of the violations identified in the body of the patient.

Taking into account the various aspects of the disorders in the body, typical methods for the treatment of psoriasis include the use of B vitamins, antihistamines and desensitizing agents, externally - ftorokort, lokakortena, salicylic, Naftalan and other ointments, flutsinar, Lorinden and many other drugs.

All of them are characterized by a common drawback: give only temporary relief and are a significant number of contraindications Yu.K.Skripkin 1994, N.A.Kalamkaryan, 1990. AP Suvorov, 1988, GJ Sharapova, 1989, SI Dovzhansky, 1992, VF Korsun 1991).

Due to the frequent involvement in the disease process in psoriasis hepatobiliary system, in the treatment of psoriasis considered indicators of serum bile acids (M.K.Baltabaev, Sh.A.Hamidov, 1996).

In the group of patients with different forms of psoriasis (including at Arthropathic, eritrodermicheskoy) previously detected increased concentration of bile acid fractions. The treatment involves the combined therapy with the use of drugs, improve metabolism, strengthen the membrane structure of the cell walls of hepatocytes (vitogepat, Syrepar, Essentiale, Kars, livomin, vitamins, biostimulants - aloe, splenin). As the authors note, a significant number of patients after the first course of treatment dissolve plaques and papules, in some patients reduces the amount of bile acids. The treatment is repeated after 2-3 week break, it gives an improvement in 50% of the remaining patients: decreased itching in the lesions gradually absorbed part of papules and plaques.

However, the effect is short-lived. The authors explain this chronic violation of the production of bile acids by the liver.

Known and the method of treatment of psoriasis (auth. St. 936918, cl. A 61 K 33/00), comprising oral administration of potassium chloride three times a day after meals, 25% solution of 6-8 ml of magnesium sulphate. Treatment continued for 2-3 days. Then appoint B vitamins, A, UFO, coal tar and other drugs.

The method has the following disadvantages:

- Erratic therapeutic effect;

- Adverse effects of drugs:

- Short period of time between relapses. (KN Veresheenko, 1971).

Known and method of treatment of psoriasis based on the content of protease inhibitors in the serum of patients. The method proposed in connection with the fact that the heavy flowing psoriasis increases the level of alpha-one antitrypsin and reduced level of alpha-two or macroglobulin. In this regard, patients are administered 50,000 units intravenously twice weekly injections contrycal 5-6. At the same time carry out the complex therapy: hiposensibilic impact, restorative, immunokorrigirujushchej, gordoks, gemodez (6 infusions of 400 ml).

Treatment lasts 1-1.5 months sometimes 2. After such treatment, patients come in about 50% of cases in clinical remission, but only improvement observed in half of the patients. All marked relapse.

A method of treating psoriasis (accepted by us as a prototype) by applying Lokoid. This drug has been created in an attempt to solve the problem of security of fluorinated steroids. Lokoid hydrocortisone-17-butyrate is halogen, its use in the form of a fatty ointment provides substantially less risk of side effects compared with halogenated steroids. Lokoid softens the skin, reduces dryness, reduces the feeling of tension, has a pleasant smell.

Patients administered the cream on the face on the isolated pockets on the trunk, extremities, scalp 2-3 times a day for mainly one month. This treatment is carried out against the background of the overall therapy. A few days later a rash in patients with pale, peeling stops.

However, as the authors (V.A.Samsonov, V.I.Hapilova, 1996) consider clinical recovery occurs in 29.8% of treated patients. General blood and urine tests, blood biochemical indices under the influence of therapy Lokoid lipokremom not undergo significant changes. On the effectiveness of the impact and the negative side effects lokoid unequivocal about flutsinar, ftorokort and other drugs.

Of all these methods are effective psoriasis treatment methods using hormones. However, the treatment causes many side effects: euphoria, sleep disturbances, feeling of heaviness and pain in the epigastric pain, heartburn, stomach bleeding, high blood pressure, obesity, pituitary type, asthenia, hypertrichosis, ulcerogenic and diabetogenic effects, osteoporosis, exacerbation of chronic infections, upset the menstrual cycle , swelling of the optic nerves, and others.

The use of cytotoxic drugs and, in addition, aromatic retinoid that is less effective and is associated with a formidable risk of serious complications (nausea, diarrhea, stomatitis, ulcerative lesions of the oral mucosa, colitis, anemia, hair loss, etc.).

A method of treating patients with non-specific respiratory diseases (Journal attendant and midwife, the N7 1982, pp. 54-56. Questions balneology, physiotherapy and exercise therapy 1982 N1, pp. 14-16), bronchial asthma, cardiovascular disease, hypertension , neuroses through the use of speleotherapy. Thus use natural and artificial caves (caverns, salt mines, mines, caves), and as an artificial climate chamber, which create certain micro-climatic conditions similar to the natural.

The treatment provides the patient stay in the microclimate on average for 270-300 hours (depending on the severity of the disease). The total course of treatment is 35-40 days. At the same time the patient is prescribed physiotherapy, exercise therapy, medicine. remission period is 9-12 months. The aforementioned source notes that highly dispersed aerosol of salt a positive impact mainly on the bronchopulmonary apparatus, but does not cure patients. The next step after speleotherapy recommended continued treatment by well-known techniques. In addition, treated patients in natural underground caves leads to an increase in the number of microflora in the caves and causes a significant change in the structure and composition of walls, chambers. In this connection, the intensity varies Speleotherapy impact on the patient.

In addition, the process of salt dust and household dust of crystalline salts, which differ in their properties from the crystalline salt. This requires a thorough cleaning of the surface of the walls and ceilings of underground compartments at least once in 1-1,5 years to a depth of 3-5 mm, the prohibition to bring in food, pre-full rehabilitation of chronic foci of infection in the body of patients before prescribing speleotherapy.

The aim of the present invention is to increase the therapeutic effect of treatment of psoriasis.

Tasks:

- Development gentle way of influence on the patient's body - reduction of terms of treatment,

- Reducing the negative side effects of medicines,

- Obtaining a positive effect in a shorter time,

- Positive impact on the general state of the patient's organism,

- Immunotherapy body.

The essence of the invention is a complex drug effects and speleotherapy. The process is as follows. Upon confirmation of the diagnosis "psoriasis", the patient is prescribed a course of speleotherapy. It involves placing a patient in an artificial climate chamber in which the air environment saturated with sodium chloride aerosol with a density of 3.5 mg per cubic meter, the 3-8 micron particle size within the 75-80%. Aerosol spray and pre-stabilized to receive treatment. Wherein the aerosol comprises iodine or anions.

Time of stay of the patient in the chamber defined by the doctor. Number of sessions per course of treatment depends on the severity of the patient and on average from 15 to 20.

In order to adapt to the patient's cell, the reception procedures increase gradually. At the same time the patient is prescribed vitamins, adaptogens (for example, Eleutherococcus, Aralia Manchurian, tincture of licorice root, and others.), Gepatoprotektory (methionine, Essentiale, holosas, lipokain), phosphodiesterase inhibitors (ATP kokarboksilaza, caffeine, etc.) And angioprotectors (Trental, nicotinic acid teonikol et al.). Medications prescribed to patients differentially, with the condition of an individual approach.

Control over the treatment is carried out by functional, laboratory and immunological parameters.

Example. Patient A., 21 years old, was admitted to the outpatient-course treatment with complaints of rashes on the skin of the trunk, upper extremities, scalp, itching in the lesions. Ill for 8 years. Every year treated different pills, vitamins, desensitizing agents, ointments (including hormonal such as tselestoderm, belosalik, sinaflana, ftorokort). An objective study did not reveal the internal organs pathology. Local status: chronic process, it is exudative character, papules pink-red color, covered with silvery-white scales. Psoriatic positive phenomena. On the scalp papules, fused to the skin of the forehead, the expression "psoriatic crown."

The diagnosis: Psoriasis is a common, papules, plaque, progressive stage, the winter season form.

The results of immunological studies: T lymphocytes of 49%, T helper 34%, T suppressor 18% B lymphocytes 8%, lgM 2,4 g / l, lgG 8,1 g / l, lgA 1,75, NK -cells 14%, 48% -fagotsitoza, 3.72 phagocytic number, phagocytic index of 1.79, 30.7% of digestion, the digestion of index 0.55.

Indicators leukocyte: leukocyte 4.9g / l, eosinophils 2%, 20.0% lymphocytes, 5% monocytes, 70% neutrophils, 5% stab, 3 ESR mm / h.

A patient being administered speleoterapija ranging from 20 to 60 minutes, N20, Aevitum 1 capsule three times a day, 20 days, calcium pangamate 1 tab. (0.05) 3 times a day, 29 days, liquorice syrup 1 tsp 3 times a day, 25 days, treatment MIL-N5, valeric coniferous bath ATF 1% -1.0 20 days, caffeine sodium benzoate -1.0 20% 20 days 0.02 pyridoxal 3 times a day 25 days. Outer: salicylic ointment 2%, Psorkutan.

As a result of the treatment on day 3 indicated blanching psoriatic lesions, reducing flaking, itching termination. After 8 days of treatment the individual papules resolved, while others were on the stage of resolution. Within 28 days after the start of treatment, all lesions resolved and the process was completed clinical recovery. After 1 year, the patient no complaints.

Indicators immunological studies after treatment: T 61% lymphocytes, T-helpers 42%, T suppressor 22%, B-lymphocytes of 10%, lgM 1,7 g / l, 12.8 lgG, 1.94 lgA, NK- 12% cells% 54% phagocytosis, phagocytic number 3.68, phagocytic index of 2.7, 68% digestion, digestion of 2.1 index.

Indicators leukocyte: leukocyte 3.2g / l eoeinofily 1.0%, 19% lymphocytes, 4.0% monocytes, segmented neutrophils, 70, stab 6 3 ESR mm / h.

The method was tested on 56 patients.

Using the proposed method allows to obtain a cure in 89.7% of patients, a significant improvement in the percentage of 100. The treatment period is 25-30 days, a period of observation of limitations is 0.5-1 years. This recurrence is not marked.

The method does not require high material costs, simple playback, highly effective, does not give negative side-effects typical of hormonal drugs, cytostatics, aromatic retinoids.

CLAIM

A method of treating psoriasis comprising the drug effect, characterized in that the physical therapy performed Speleotherapy artificial climate chamber in which the medium is saturated with sodium chloride aerosol with a density of 3 - 5 mg / m3, particle size 3 - 5 mm.

print version
Publication date 01.04.2007gg