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INVENTION
Russian Federation Patent RU2140791
METHOD OF TREATMENT True eczema
Name of the inventor: Ali Kathanov Muratovic; Boyko Natalia
The name of the patentee: Kathanov Ali Muratovic; Boyko Natalia
Address for correspondence: 350063, Krasnodar, ul.Sedina 4 Kuban Medical Academy Patent Department Doroninoj TA
Starting date of the patent: 1996.01.03
The invention relates to medicine, namely to dermatology, and can be used to treat eczema true. To do this on the background of antibacterial therapy arbaktalom spend an immunomodulating therapy and allergen stafiloprotektinom. The method allows to reduce the time of treatment of eczema, to extend the period of remission and reduce the number of relapses in 8 times.
DESCRIPTION OF THE INVENTION
The invention relates to medicine and can be used in the treatment of skin disease - true eczema.
It refers to True eczema dermatoses, the pathogenesis of which plays a decisive role sensitization to allergens, including those of bacterial origin.
According to the literature, 90,7-98,2% of children discharged from the hospital already sensitized Staphylococcus, while obvious, manifest forms of the disease (tonsillitis, otitis, sinusitis, cholecystitis) can not be observed. Traditionally, control of chronic, focal diseases using antibiotics (tetracycline, aminoglycosides, macrolides), and for desensitization - repeatedly diluted allergen aureus (Annex N 1 to the Regulations of the USSR Ministry of Health 1976), which is often ineffective and will not prevent the development of relapses, because these groups antibiotics, unfortunately, lost its effectiveness due to the formation of b -laktamazoprodutsiruyuschih staphylococcus strains, and this method desensitization lasts a few months or years, causing aggravation in 25% of patients and adverse reactions such as anaphylaxis approximately 30% of patients, forcing discontinue treatment.
A method of treating a true eczema (Novikov GM Eczema (the role of immune disorders, endocrine system and cell membranes, clinical and experimental studies, Methodological treatment): Abstract Dis dokt.med Sciences - Sverdlovsk, 1987. - 16..... -18 s), including non-specific immunotherapy (timogenom, splenin, levamisole), vitamin (vitamin B, a), improvement of microcirculation (trental, nicotinic acid), hypersensitivity to piokokkam -. antibiotics. Local treatment - depending on the process steps of: lotions, pastes, creams.
The disadvantages of the method include the lack of sanitation; duration of therapy (more than 1 month); the absence of clinical and immunological monitoring conducted after medical manipulations.
For a prototype accepted method for the treatment of eczema (Tkachenko LA Complex treatment of patients with microbial eczema using immuno- and herbal medicine Abstract Thesis Candidate of medical sciences -.... Kyiv, 1990. -. 17-18 s), including the use of antibiotics in combination with a non-specific immunotherapy measles gamma globulin donor, enterosorbent brand SKNP-2, and the outer herbal drugs from medicinal plant extracts (oak bark, St. John's wort grass, pine buds), produced by evaporation.
The method does not take into account the depth of disorders of immunity, depending on the degree of bacterial sensitization, simply stating the fact of its existence. The consequence of this is the lack of individual approach to the patient and the inability to forecast the flow of dermatosis.
Invention Problems - improving therapeutic efficacy, reduction of terms of treatment, the lengthening of remission, improving long-term results and therefore more resistant rehabilitation of patients with true eczema.
We first developed the scheme of treatment of patients with true eczema and sensitization to the golden Staphylococcus epidermidis, which provides application Abaktala (pefloxacin) - a synthetic antimicrobial agent derived oksihinolonkarbonovoy acid. The quinolones have a wide spectrum of antimicrobial activity, including trudnopodavlyaemye and resting cells; activity within the cell, the inhibition of DNA-hydrazo, rapid and wide distribution in the body. In addition, we have identified and immunocorrecting hyposensitizing effect stafiloprotektina, whose identity is not only in domestic work, to study the impact stafiloprotektina with pyoderma (Tlish MM "Complex therapy of patients with chronic stafilodermiyami stafiloprotektinom and differentiated immunotherapy". Dis. Candidate of medical sciences , Krasnodar, 1992, pp. 27, 38-40, 80-100, 102, 103, 115), which did not specify the level of sensitization either in vitro, or in vivo, and did not study the properties of hyposensitization stafiloprotektina.
The essence of the invention is that the true eczema patient with sensitization to staphylococci appoint hiposensibilic and immunomodulating treatment and antibiotic therapy stafiloprotektinom abaktalom.
Treatment of patients with true eczema sensitive to staphylococcus carried out by the following procedure:
- Antibacterial treatment abaktalom 400 mg twice a day (morning, evening) for six days;
- Specific immunotherapy and allergen therapy native stafiloprotektinom whose injections were subcutaneously into the bottom corner of the blade under the scheme (0.2; 0.3; 0.5; 0.8) with an interval of 2-3 days; revaccination performed adsorbed stafiloprotektinom 2 months after immunization.
Other tools used were traditional:
- Valerian tincture 20 drops three times a day for 15 days;
- Sodium thiosulfate (a desensitizing, antiinflammatory, protivotoksicheskoe purpose) 30% solution, 10 mL intravenously every other day, 10 injections;
- Reserpine (with normal blood pressure for "serotoninopustoshayuschego effect") to 0.00025 1 times a day, 7 days;
- Aevitum 1 capsule per day to 14 days;
- Intestinal lavage with mineral water (to reduce the antigenic stimulation of the small and large intestine) 5 times a day;
- External treatment of patients was carried out according to the process.
The method has been tested in more than 1,000 patients in a hospital in the edges of the STI clinic.
Patient T., 22 years old. The diagnosis: a true eczema in the acute stage. Concomitant diseases: chronic tonsillitis. On admission the patient complained of itching and oozing in the upper extremities. there was no pain in the throat. Sick for 2 years. Eczema first appeared after strong emotions in the service of the army. Angina is ill since childhood 2-3 times a year. Repeatedly treated by a dermatologist at the place of residence of calcium preparations, vitamins, antihistamines, lotions, corticosteroid ointments, but the recurrence of the disease lasted for 2-3 times a year. Composed on the dispensary at the ENT doctor, which periodically receives antibiotic irrigation of the tonsils, throat gargle solutions hlorofillipta and Lugol, UV irradiation (OKUF). On examination: skin disease process is common, symmetrical, localized on the hands of both hands.
Presented ostrovospalitelnoy edematous erythema, vesicles, weeping, crusts grayish-yellow color. Outbreaks have no clear boundaries.
The taking of blood on the immune status
LT 3 - 51%, 3F - 18%, LT 4 - 35%, LT 8 - 17%, LT 4 / LT 8 - 2.0.
The reaction of the specific S.aureus with rosette - 38%, S.epidermidis - 47% (average degree of sensitization).
Treatment:
1) stafiloprotektin subcutaneously into the lower angle blades to 0.2; 0.3; 0.5 and 0.8 ml after two days;
2) abaktal 400 mg in the morning and evening, 6 days;
3) after the above mentioned manipulations - Sodium thiosulphate 30% solution, 10 ml intravenous infusion 10;
4) 0.00025 reserpine on the morning after a meal, 7 days;
5) Aevitum 1 capsule a day, 14 days;
6) washing the mineral water of the intestine is 5 times a day;
7) externally - first lotions from broth herb St. John's wort and pine buds, then paste Lassara.
On the 12 th day of the treatment process of the skin completely regressed. During the 3-year follow-up for patients with recurrences were noted. The results of repeated examinations of the immune status and sensitization showed normalization of all parameters.
Patient A., 34 years old. The diagnosis: a true eczema in the acute stage. From accompanying diseases: recurrent purulent otitis left. On admission the patient complained of itching and oozing in the upper and lower extremities. Sick eczema 7 years. Onset of the disease with nothing in common. Otitis acute 3-4 times a year for 4 years. Double treated in STI clinics in the community. Therapy: vitamin, allergen agents, corticosteroid ointments were ineffective: relapse continued for 2 times a year. More than once appealed to the otolaryngologist, who appointed "Dexon", "Sofradeks" warm and dry "Ray-3" in the area of the ear.
On examination: skin disease process is common, symmetrical, localized on the hands of both arms and both legs. Presented bubbles, erosions with weeping surface, is located on the hyperemic hydropic background, isolated putulami sluggish, yellow crusts.
On the day of admission, the patient's blood is taken on the immune status and the amount of antigen-rosette-forming cells (degree of sensitization staphylococcal). Immunosuppression is found on all counts and a high level of sensitization. Assigned treatment on our way: stafiloprotektin subcutaneously, alternating right and left corner of the scapula to 0.2; 0.3; 0.5 and 0.8 ml 2 days. Simultaneously with injections: 1 tablet abaktal 2 times a day, six days. After stafiloprotektina and Abaktala - Sodium thiosulphate 30% solution of 10 ml 10 N intravenously, reserpine 1/4 tablets in the morning, 7 days, Aevitum 1 capsule a day, 14 days, and intestinal lavage with mineral water 5 times a day . Locally: on moist areas - lotion with drilling fluid and a decoction of pine buds, then - cream "Beloderm".
On the 18th day of hospitalization were only hyperpigmented spots on the site of the former lesions. After the treatment, and after 2 years of follow-up examination is done, indicating almost complete normalization of immune homeostasis and a state of heightened sensitivity to staphylococcus.
Thus, the method of treatment provides more rapid regression of symptoms of the disease, reduces the length of hospital stay (7.4 days), the remission period lengthens, reduces the number of relapses in 8-fold when compared with the conventional method of treatment, and consequently, economic effect.
The developed method is simple and complex therapy is available for widespread use in hospital and outpatient clinic.
CLAIM
A method for treating a true eczema, including medical effects, including antibacterial, and immunomodulating hiposensibilic, characterized in that the antibiotic therapy is arbaktalom and allergen immunotherapy - stafiloprotektinom.
print version
Publication date 01.04.2007gg
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