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INVENTION
Russian Federation Patent RU2149002

METHOD FOR THE TREATMENT OF PSORIASIS

METHOD FOR THE TREATMENT OF PSORIASIS

Name of the inventor: Bahmisterova AA .; Bychko-current IS .; Novikova LV
The name of the patentee: Mordovia State University. NP Ogareva
Address for correspondence: 430000, Mordovia, Saransk, st. The Bolshevik 68, Moscow State University. NPOgareva, pat.otdel
Starting date of the patent: 1996.12.27

The invention relates to medicine, in particular dermatology, and can be used for the treatment of psoriasis. It is proposed to background therapy including desensitization, indifferent ointment and UV exposure, to conduct a comprehensive immunocorrection including detoxication therapy using enterosorbent such as activated carbon, a downward pattern in two months, immunomodulation T-activin for prolonged scheme up to six months, normalization of liver function karsilom, vascular therapy using cinnarizine, antioxidant therapy "Aevitum" and a multivitamin with trace elements in alternating monthly courses year-round. The method allows to achieve clinical and immunological remission in a shorter time.

DESCRIPTION OF THE INVENTION

The invention relates to medicine, in particular dermatology, and can be used in clinical practice.

There is a method immunotropic treatment of psoriasis, which comprises administering to the background of conventional therapy cytostatic methotrexate in a specific pattern (see the treatment of skin diseases: A Guide for Physicians / Ed Mashkilleysona AL - M .: Medicine, 1990 - with 311.... - 312).

The disadvantages of this method are the early recurrence of the disease, which is much greater; irreversible changes in the liver structure, function is disrupted in psoriasis; increased risk of early neoplastic process; purpose limitation methotrexate parties for children and the elderly; side effects, which are peculiar to all cytostatic therapy. In addition, the use of metotraksata in psoriasis does not affect the main elements of its pathogenesis, and affects only the end result of a multi-component disease process - a violation of the proliferation and differentiation epidermotsitov.

The closest to the proposed method for the treatment of psoriasis is the method of efferent therapy, which is used on a background of conventional therapy (desensitization using the H 1 receptor blockers, indifferent ointments, ultraviolet radiation) and is non-pharmacological stimulation of the natural immunity system, the physiological mechanisms sanogenesis with the normalization of life processes ., by the elimination of detoxification of xenobiotics various biological fluids, toxins and products "metabolic amputation" (see Sharapova Psoriasis GY et al (immunomehanizmy pathogenesis and treatment.) -. M .: Meditsina, 1989, p 89. - 140).

However, this method of treatment has several drawbacks: requires special equipment and trained staff, while its efficiency is not high elongation provides remission; because of side effects may require their cancellation; It has age limits, and contraindications associated with the concomitant diseases.

The technical effect is to develop pathogenetically sound method of treatment of psoriatic disease, allowing to achieve clinical and immunological remission in a shorter time.

The invention consists in that in a method of treating psoriasis effected during therapy comprising desensitization, ointments and indifferent ultraviolet irradiation, conducted immunocorrection complex comprising detoxication enterosorbent therapy using, for example activated carbon, in descending pattern within two months; immunomodulation T-activin for prolonged scheme up to six months; normalization of liver function karsilom; vascular therapy using cinnarizine; antioxidant therapy - "Aevitum" and a multivitamin with trace elements year-round, in alternation.

The process is as follows. Patients with a variety of clinical forms of psoriasis amid conventional therapy (desinsibilizatsiya example Phencarolum 0,025 3 times a day, 0,001 Tavegilum 2 times a day an ointment indifferent example 3-5% salicylic ointment ultraviolet irradiation) is carried out detoxication treatment with activated coal tablets downlink circuit. Of 0.25 g per 10 kg weight at a time, three times a day. Weekly single dose is reduced to 0.25 and gradually brought up to 0.1 g per 10 kg of body weight per day, singly. The general course of 2 months. After 3-5 days from the beginning detoxification therapy or concurrently with domestic immunomodulator assigned T-activin in a dose of 100 micrograms (0.01% - 1.0), subcutaneously at night (or an analogue timalin 10 mg, intramuscular) scheme 1 week - daily 2 weeks - 2 times a week, from 3 to 8 weeks - weekly. Depending on the severity of the process, dermatosis ago, the dynamics of immunological parameters, rate of thymus preparations extended to 6 months. From the first to the treatment for the normalization of liver function are assigned gepatoprotektory - Kars (legalon) at a dose of 0.07 to 3 doses for 1.5 - 2 months. In addition, vascular therapy is performed by assigning cinnarizine in 0,025 doses 3 times a day, the overall rate of 1.5 - 2 months. At the same time carry out antioxidant therapy by appointment "Aevitum" 1 capsule 2 times a day, and multivitamin preparations with trace elements in individual doses, for example, in Table 1. 2 times a day, "Complivit" monthly rates, in the alternation of the year.

Depending on the patient's general condition, the area of ​​lesions of the skin, which may indirectly indicate severity of endogenous intoxication, can be assigned to a parenteral detoxification - at 400.0 gemodez intravenous drip, every other day. Only 2 - 3 infusion.

Example 1. Patient I., 24 years complained of the appearance of itchy rash, accompanied by scaling, pain and stiffness of the joints of the hands and feet, wrist, ankle and elbow; general malaise, poor sleep. Sick for the first time, it links the disease with a difficult birth 6 months ago. Father sick - psoriasis. From accompanying diseases - gastric ulcer. Objectively: on the scalp, face, trunk, in the extensor surfaces of the joints of a finite set of papules, sometimes coalescing into plaques, intense pink color, moderately infiltrated, covered with silvery scales. Psoriatic triad (+) positive. Visible changes over the area of ​​the affected joints do not have; R-logically - signs of arthropathy I degree. In general clinical analyzes, except for elevated erythrocyte sedimentation rate of 25 mm / h, without deviation. In immunogram neutropenia, increased absolute and relative number of T cells and hyperimmune A G, enhancing phagocytic activity, the absence of T-suppression gipokomplementemiya increase in circulating immune complexes (CIC).

Assigned treatment: gemodez at 200.0 intravenous drip 2 days. Activated carbon according to the scheme: 1 week - 6 tablets 3 times a day, 2 weeks - 5 tablets three times a day, 3 weeks - 4 tablets 3 times a day, four weeks - 3 tablets 3 times a day, 5 week - 2 tablets three times a day, 6-8 weeks - 2 tablets at night. Karsil at 0.07 x 3 times a day, cinnarizine 0,025 x 3 times a day, "Aevitum" x 1 capsule 2 times a day, "Complivit" 1 tablet x 2 times daily, topically 2% salicylic vaseline, daily bath. Brufen 0.2 x 2 times per day. On the 3rd day of treatment - injections of T-activin 0.01% - 1.0 subcutaneously at night, according to the scheme: 1 week - every day, 2 week, 2 times a week at intervals of 3 days, from 3 - 8 weeks 1 injection in week. A total of 15 injections.

The treatment of the itching disappeared on the 3rd day, normal sleep, on the 8th day there was a process of stabilization: rash paled considerably reduced scaling in the centers; on the 10th day appeared "collar" Voronov, to 21 days only pigmentation noted on sites of former eruptions. Arthralgia has decreased on the 3rd day of treatment and completely disappeared within a week.

In the immunological sick after reaching clinical remission were observed positive changes: minor hyperimmune A, decrease in neutrophil phagocytic activity and normalization of the ratio of subpopulations of T-lymphocytes, the normalization of the concentration of the total complement of the CEC and serum. A year later, there was no recurrence.

Example 2. Patient B., 41 years old, suffers from the summer form of psoriasis for 20 years. 13 years ago I was diagnosed with psoriatic arthropathy, a disabled group III. Each year, 1-2 times a year is treated in a hospital RKVD. After the treatment, including traditional antihistamines, vitamins, biogenic agents, absorbable, non-steroidal anti-inflammatories, hormonal ointments are discharged with improvement, a complete remission did not occur even once. Last exacerbation of cutaneous and articular process occurred in August 1995. Indicators of general clinical analyzes - without abnormalities. In immunogram - signs immunodetsifita with an autoimmune component. Assigned treatment gemodez at 400.0 intravenously, every other day, 2 infusions; Activated Carbon 1 week - 7 tablets 3 times a day, 2 week - 6 tablets 3 times a day, 3 weeks - 5 tablets 3 times a day, four weeks - 4 tablets 3 times a day 5 week - 3 tablets 3 times a day, week 6 - 2 tablets 3 times a day, 7 - 8 weeks - 3 tablets at night. On the fourth day of treatment T-activin 0.01% - 1.0 p / c at night, according to the scheme: 1 week - every day, 2 week - 2 times a week, 3 - 16 weeks - 1 time per week. 0.07 Karsil by 3 times a day, the course of 2 months. Cinnarizine 0,025 3 times a day for 2 months. "Aevitum" 1 capsule 2 times a day, a month, "Complivit" 1 tablet 2 times a day; then alternating monthly courses. Tavegil 0,001 2 times a day for 10 days. Brufen 0.2 3 times a day for 15 days. Local: 3% salicylic ointment. Daily baths. Ultrasound paravertebrally. Against the background of the therapy process stabilization stepped on a 8-4 day; blanching psoriatic elements, reduction of flaking on the 10th day; regress efflorescence on the 15th day. Joint pain, feeling of stiffness decreased by 6 day and disappeared on the 12th day. Cleansing of the skin occurred in the 32-day hospital stay. In the control immunogram: normalization of relations subpopulations of T-lymphocytes, the CEC and the level of concentration of Ig; hyperactivity neutrophilic phagocytes giperkomplementemiya. Recurrence of the disease occurred in 13 months and is considerably lighter.

Due diligence immunomodulating treatment in 35 patients with different clinical forms of psoriasis on the proposed method showed a high clinical efficacy (97%). Hospital stay was reduced by 1.8 times. Recurrence of the disease has not been through 0.5 years in any case. The use of this treatment method is not limited to age of patients and has no contraindications (except for individual intolerances), it has no side effects, which would have caused the abolition of drugs. Pathogenic expediency and great breadth of therapeutic action allow the use of the proposed complex drugs is long and / or repeated courses. Finally, the full range of drugs readily available to the consumer and does not require special skills and special laboratory control during his appointment to patients, but also special equipment, can be used even on an outpatient basis.

CLAIM

A method of treating psoriasis exercised during therapy comprising desensitization, indifferent ointments and ultraviolet irradiation, wherein the carried complex immunocorrection comprising disintoxication therapy using enterosorbent such as activated carbon, descending pattern within 2 months immunomodulation of T-activin in depending on the severity and duration of the disease from 2 to 6 months, normalization of liver function karsilom, vascular therapy using cinnarizine, antioxidant therapy "Aevitum" and a multivitamin with trace elements in alternating monthly courses year-round.

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Publication date 01.04.2007gg