| Start of section
Production, amateur Radio amateurs Aircraft model, rocket-model Useful, entertaining |
Stealth Master
Electronics Physics Technologies Inventions |
Secrets of the cosmos
Secrets of the Earth Secrets of the Ocean Tricks Map of section |
  |
| Use of the site materials is allowed subject to the link (for websites - hyperlinks) | |||
Navigation: => |
Home / Patent catalog / Catalog section / Back / |
|
INVENTION
Patent of the Russian Federation RU2007179
METHOD OF TREATMENT OF PSORIASIS AND NEURODERMITHE
The name of the inventor: A.Ya. Potapenko; Kagova AA; Childless LN; Lysenko EP; Chernyakhovskaya I.Yu .; Bekhalo VA; Nagurskaya EV; Nesterenko VG; Short NG; Akhtyamov SN; Krylenkov VA; Lanshchikova TM
The name of the patent owner: Potapenko Alexander Yakovlevich
Address for correspondence:
The effective date of the patent: 1992.01.09
The invention relates to medicine, namely to the treatment of psoriasis and neurodermatitis. The aim of the invention is to shorten the treatment period and prolong the period of remission. The essence of the invention is that psoralen is irradiated before administration, with a course of treatment of 10-12 days, a dose of 1 mg per reception. The advantage of the method is to improve the functional results.
DESCRIPTION OF THE INVENTION
The invention relates to medicine, namely to the treatment of psoriasis and neurodermatitis.
Currently, the clinical practice uses the method of PUFA-therapy of many skin diseases (psoriasis, vitiligo, nests of baldness, cutaneous T-cell lymphoma, atopic eczema, etc.). The method consists in the combined use of psoralens (furocoumarins) and UV-A radiation (320-400 nm). After the administration of psoralens, either human skin (PUFA-therapy) or a fraction of blood lymphocytes (photopheresis), selected as a prototype, is subjected to UV-A-irradiation.
However, PUFA therapy has the following drawbacks: a long (20-30 sessions) course consisting of general irradiation of the body of patients with ultraviolet A, which is not indifferent to the health of patients, since repeated UV-A radiation can increase the incidence of skin cancer.
Photopheresis and has the following drawbacks. In addition to significant cost, it requires multiple use of the device for photopheresis, in addition, intravenous injection of large amounts of blood and its components may pose a risk of contracting HIV.
There are also known methods of treating psoriasis by using various medications (anti-inflammatory, antihistamines, etc.) or with the help of physiotherapy procedures - sea bathing, sulfur baths, and using external means (ointments, creams).
The aim of the invention is to shorten the treatment period and prolong the period of remission.
The goal is achieved by the fact that, unlike the known method, including the administration of psoralen and subsequent irradiation of the patient, in this method, psoralen is pre-irradiated, with a course of treatment of 10-12 days, and a dose of 1 mg per reception.
Investigation of the mechanisms of action of the PUFA-therapy and photopheresis led to the assumption that the key moment of the therapeutic effect is the suppression of the T-system of immunity.
Studies were conducted in mice that showed the following. Decreased delayed hypersensitivity reaction (HRT). Hybrid mice (CBA x C57BL / 6) F1 were sensitized by intravenous administration of 5x105 ml of erythrocytes of ram (EB). The level of sensibilization was determined on the fourth day. To this end, 108 ml of EB were injected into 40 ml of physiological solution into the pad of the experimental mouse foot, physiological saline solution was injected into the control (contralateral) paw in the same volume. The intensity of the HRT reaction was determined after 24 hours for the thickness difference between the test and control legs. For the unit of reaction, the HRT took a difference of 0.1 mm. Unmodified psoralen (Pc) or modified psoralen (PcD) was administered intravenously in 0.5 ml at two concentrations of 5 U / ml or 30 U / ml 24 hours after sensitization of the EB (afferent phase of the reaction) or 72 hours after sensitization of EB (effector Phase of the reaction). There was a significant decrease in the level of the reaction of GTP to EB by the introduction of PSD at a concentration of 30 U / ml in both phases of the HRT reaction, and at a concentration of 5 U / ml per effector phase of the reaction compared with the positive control and with the introduction of unmodified psoralen.
In addition to PSD, derivatives of other furocoumarins (angelicin, 8-Mop, peycedanin) were used. Unmodified preparations and modified ones were administered intravenously 72 hours after EB sensitization. Peitsedanin D, 8-Mop D significantly reduced the level of HRT reaction in comparison with the positive control and the introduction of unmodified furocoumarins. Based on preliminary data from one experiment, there was no difference between unmodified angelicin and the derivative of angelicin.
Inhibition of the growth of the grafted T-cell lymphoma EL-4 in C57BL / 6 mice under the influence of PDD. C57BL / 6 mice were subcutaneously injected into the back region with 0.2 ml of a suspension of EL-4 lymphoma cells in medium 199 in an amount of 107 cells. Registration of tumor growth in dynamics was carried out by measuring its area by surface palpation. The tumor mass was evaluated on the 15th day after tumor transplantation. The tumor began to palpate on the 5th day after its transplant, followed by a sharp increase in its area by the 15th day. The action of the PDI was carried out in two versions. In the first case, PSD injection was intravenously (0.5 ml, concentration 30 U / ml) on the sixth day after tumor transplantation and was repeated 6 times during the following 9 days, while on the 15th day there was a 2-fold inhibition of tumor development. In another case, the first injection of PDV (0.5 ml, 30 U / ml) was done 30 minutes before the tumor was transplanted, then PSD injections were repeated 9 times for 15 days. This led on the 15th day to a 3-fold inhibition of the tumor.
In addition to measuring the tumor area in the same experimental and control group of animals, on the 15th day after tumor transplantation, the mice were sacrificed and the tumor mass was determined. It can be seen that in the groups with the introduced PSD, a significant decrease in tumor mass is observed in comparison with the control. It can be seen that in the case of the simultaneous introduction of PSD, the effect is much better.
The method is carried out as follows
Example 1 . Patient R. 23 years old, entered the department of dermatology with a diagnosis of limited neurodermatitis in the acute stage. She is sick for 12 years. Exacerbations occur annually in the autumn-winter period. It was treated with calcium preparations, antihistamines, UV irradiation, glucocorticoid ointments, group B vitamins. However, the process began to worsen at the end of 1990 and the patient did not notice any improvement from the listed methods of treatment. On examination, it was noted: hyperemia, infiltration, traces of scratching, lichenification in the elbows, popliteal folds, on the face. From the internal organs there is a hyperacid gastritis, calculous cholecystitis. In blood tests expressed zosinophilia - 26.
The treatment of PdD by 50 ml 3 times a week on an empty stomach is shown. In all, the patient received 15 procedures. After the first session of PDS, there was a therapeutic effect: the itching decreased. After the 4th session, the manifestations on the skin began to decrease. In the analysis of blood taken after 8 days, the number of cases of zosinophilia decreased to 14, and to 12th session - to 8. The patient was recommended to continue treatment.
Example 2 . Patient N., 18 years old, entered the department of dermatology with a diagnosis of diffuse neurodermatitis in the acute stage. Has been sick for 10 years. The skin process from the very beginning took a continuously-recurrent nature, despite the various methods of treatment: hormones, antihistamines, plasmapheresis. On examination, it was noted: hyperemia, infiltration, peeling, swelling of the skin, an increase in all groups of regional lymph nodes. Internal pathology has not been revealed. In the analysis of blood there is a small leukocytosis - 8000, zosinophilia up to 18.
The treatment of PdD by 50 ml 3 times a week on an empty stomach is shown. In all, the patient received 12 procedures. After 3 procedures in a row, there was a decrease in itching, puffiness and infiltration of the skin. Due to objective reasons, the patient could receive the procedures not in a day, but in a row 3 days a week, in this regard, the effect of treatment was unstable and by the beginning of the next cycle of procedures, itching and swelling increased. The treatment is currently continued in a modified mode - every other day.
Example 3 . Patient D., 21, entered the department of dermatology with a diagnosis of diffuse neurodermatitis in the acute stage. Ill since early childhood. Repeatedly received various treatment methods (antihistamines, enteroseptol, nystatin, colibacterin, nicotinic acid, allahol, peritol, splenin, radedorm, cryotherapy, corticosteroid therapy, etc.). However, the effectiveness of treatment was inadequate. The last aggravation began three months before admission to the department. When you receive a complaint about a permanent biopsy intense itching, worse at night, a feeling of tightening the skin. When examined from the internal organs pathologies are not revealed. Localization status: the pathological skin process has a widespread symmetrical character, multiple lesions located on the chest, extremities, lower abdomen, face, neck, skin folds. Skin covers are markedly dry, cyanotic coloration with hyperpigmentation and secondary amyloidosis, shagreen skin. Primary morphological elements are represented by infiltrated papules with uneven edges, which tend to merge. At the confluence, the areas of lichenization are formed. On the surface of the foci, numerous secondary pathological elements are seen - excoriations covered with sero-hemorrhagic crusts. The face of the patient is edematic, hyperemic, covered in the cheek and forehead area with small chalices. Nails have a polished appearance. Considering the prescription of the disease, the prevalence of skin lesions, as well as torpidity to traditional methods of treatment, the patient was treated with PDS 50 ml per day on an empty stomach 6 times a week.
After 2 treatment sessions, there was a decrease in itching, decreased hyperemia, infiltration in the face, swelling in the eyelid. After 4 sessions, the itching and cyanoticity of the skin completely disappeared. After 7 sessions, the skin was lightened, and in some places physiological staining was obtained. Clearly there is a decrease in the number of crusts, peeling, the disappearance of edema from most of the skin (swelling is preserved only in the folds of the skin). After 14 sessions of PDS - skin integuments had physiological staining, were elastic, completely erythema and lichenization was resolved, slight hyperemia of skin folds was preserved, secondary pathological elements were not detected. The data of the general picture correspond to the diagnosis: clinical remission. The patient is recommended to continue treatment to fix the effect within 2 weeks.
Example 4 . The patient B. 34 years old, entered the department of dermatology with the diagnosis: eczema in the acute stage. Sick for a month. The disease began after contact with the cement, redness and itching appeared in the area of the wrist joints, then the process spread completely to both limbs and neck. When you receive a complaint about paroxysmal intense itching, worse at night, a feeling of tightening the skin. When examining the pathology from the internal organs is not revealed. Localization status: the pathological skin process is widespread and symmetrical, localizing in the neck, upper chest, upper limbs, including the shoulder joint, lower extremities to the level of the knee joint. Skin covers are brightly hyperemic and infiltrated. Of the primary pathological elements - edematous erythema, against which microvesicles, micropapules, multiple erosions, abundantly presented serous and serous - haemorragic crusts, excoriation.
The patient was treated with PDS 50 ml per week 6 times a week. In all, the patient received 8 procedures. After the first session of PDS, the itching decreased sharply, edema decreased. After the 2nd session, hyperemia disappeared, swelling in the neck, upper chest, on the upper limbs, the level of infiltrative hyperemia descended to the middle of the shoulder, on the lower limbs - to the level of the ankle joint, the number of microvesicles and micropoups dropped sharply. After the 4th session of PDS - the itching and skin tightening sensation are absent, the level of infiltrative hyperemia on the upper limbs has descended to the middle part of the forearm, there is a significant cleansing of the skin: the serous and serous-hemorrhagic crusts, excoriations have disappeared. After the 6th session, hyperemia was preserved only in the area of the skin folds of the wrist joints; in other parts the skin had physiological staining, was elastic, cool to the touch, there was no swelling and infiltration, erosive surfaces, the skin of the upper extremities was completely cleansed. After the 8th session, complete regression of the pathological process was noted. The patient is discharged in a state of clinical remission.
Example 5 . Patient S. 6 years old, entered the department of dermatology in a serious condition with a generalized eczematous process complicated by secondary pyoderma. He is sick from the age of one month after being transferred to artificial feeding. Initially, the eczematous process was localized on the face, and from the first year of life it spread to the extremities, the trunk, despite the ongoing therapy with antihistamines, vitamin and antibiotic therapy, and local treatment with hormonal ointments.
On examination, multiple hemorrhagic crusts, traces of scratching, purulent crusts, multiple pustular and papular elements, the phenomena of cheilitis, in the oral area, a continuous purulent crust, and cracks were noted. The itch was permanent. PSD treatment was carried out for 50 ml of wasp. In total, the child received 12 PDS procedures. After the 4th procedure, the itching decreased sharply. After the 8th procedure, there was a significant cleansing of the skin, the pustular elements practically disappeared, the ecdysis decreased significantly, the erythema decreased. However, in the mouth area, despite the disappearance of the pustular elements, infiltration decreased slightly. The data of the general picture correspond to the diagnosis: clinical remission. Treatment with PDS is planned to continue.
Example 6 . Patient T. 30 years, entered the department of dermatology with a diagnosis: exacerbation of chronic eczema complicated by secondary pyoderma. He is sick for about 12 years. The eczematous process was localized practically on the entire skin. The examination noted: swelling of the skin in the face and neck, infiltration, foci of mocclusion in the upper and lower extremities, multiple well-defined papulopustular eruptions, traces of scratching. The patient was tormented by constant itching.
The patient was treated with PSD 50 ml per os 6 times a week. Already at the 3rd session of PDS, signs of clinical improvement became noticeable: the edema and infiltration of the skin were markedly reduced. Twelve procedures were performed, as a result of which the itching practically disappeared, only small areas of lichenification remained. The data of the general picture corresponded to the diagnosis: clinical remission. The patient himself interrupted the course of treatment.
Example 7 . Patient K. 16 years old, was in the dermatological department on an outpatient treatment with a clinical diagnosis: vulgar acne. Is sick for 2 years. The disease had a progressive nature. Received treatment with antibacterial, antihistamine drugs, nonspecific anti-inflammatory drugs, vitamins, membrane stabilizing drugs. Treatment was with a mild effect. When examining the patient: the pathology of the internal organs is not revealed. Localization status: the pathological process was widespread, localized on the skin of the upper chest and back; Rashes are represented by small inflammatory papules, purulent pustules, comedones in the form of black dots: from secondary pathological elements - crusts, in place of some old acne rashes - scars, areas of hyperpigmentation.
The patient was treated with PDS 50 ml on an empty stomach 6 times a week. The first signs of clinical improvement appeared after 7 sessions of PDS. There was a decrease in the number of acne eruptions. Under the influence of the therapy, the resolution of the primary morphological elements (papules, pustules) was observed, the secondary morphological elements gradually disappeared. The general condition of the patient corresponds to the diagnosis: clinical remission.
Example 8 . Patient N., 17 years old, entered the department of dermatology with the diagnosis: conglobata acne. Is sick for 3 years. Despite the constant cleaning of the skin, antibiotic therapy, immunotherapy, the use of a variety of lotions, acne eruptions have progressed. The examination noted: large conglobata acne eruptions, localized in the face, neck, chest, back with abundant purulent contents.
The treatment was carried out using PDS 50 ml per week, fasting 4 times a week, additional gauze wipes moistened with Pseudomonasemia were added to large acne for 15 min. In all, the patient received 14 procedures. The first signs of improvement appeared after 8 sessions of PDS: acne eruptions began to decrease, so far no new pustular element appeared for 3 weeks, scars are noted in place of old acne.
Example 9 . Patient A., 29 years old, was diagnosed with: widespread psoriasis, arthropathic form in the stage of exacerbation.
He is 10 years old. Exacerbations in the autumn-winter period. The disease has a slowly progressive nature. She was treated repeatedly in the hospital with traditional methods (antihistamines, sedatives, hormones, vitamin preparations) with insignificant effect.
Concomitant pathology: an increase in goiter II-III degree, from other organs and pathology systems is not revealed.
Complaints about pain in the joints, itching in the area of the rash.
Pathologically the skin process has a generalized character, it is spread over the whole surface of the body. It is represented by numerous papular elements of pink color, covered with silvery scales. In some places papules are fused into dense infiltrated plaques extending up to 30 cm. The arthropathic triad is positive. Nails changed by the type of "thimble". The joints of the hands, feet, elbows and knees are thickened, altered, painful when moving.
Given the duration, course, severity of the disease, and torpidity to traditional methods of treatment, the patient is prescribed PDD-therapy according to the scheme: 6 times a week for 50 ml of PDS in the morning on an empty stomach. In total, the patient received 44 sessions. After 10 sessions, in addition to PSD, selective phototherapy (UV-B) was prescribed.
After the 3rd session, there was a decrease in itching and joint pain. The process has stabilized. After the 5th session, there was a simplification and blanching of the plaques. After the 8th session, the appearance of an atrophic corolla in plaques was noted. After 10 sessions, some of the plaques broke up, areas of apparently healthy skin appeared. After the 10th session, in parallel with PDD, UV-B therapy was administered daily with suberythmic doses. After the 15th session, a sharp increase in the rate of resolution of the pathology of the skin process was noted. After the 20th session, hands were cleansed, after 30 sessions - the trunk and buttocks, after 40 sessions, legs were cleared, hyperpigmentation remained at the sites of pathology resolution. The patient is discharged with the diagnosis: clinical remission.
Example 10 Patient G., 19 years old, was diagnosed with advanced psoriasis progressing stage.
Ill since 3 years. Exacerbations were observed in the autumn-winter period. Repeatedly treated ambulatory and in a hospital with a weak effect of traditional methods (antihistamines, sedatives, hormones and vitamin preparations).
Associated pathologies are not revealed.
Complaints about itching, a feeling of tightening the skin.
The pathological skin process is widespread, spreading throughout the skin. It is represented by multiple papular elements of pink color, covered with silvery scales. In some places papules merge into dense infiltrated plaques up to 3 cm in diameter. Psoriatic triad is positive.
Given the duration of the disease, its course, as well as the torpidity of the traditional methods of treatment, the patient underwent PSD therapy according to the scheme: 50 ml in the morning, on an empty stomach, 6 times a week. In all, the patient received 16 sessions.
After 3 sessions the itch disappeared. After 6 sessions there was a simplification of papular elements, the process was stabilized. After 12 sessions, a partial resolution of the cutaneous pathological process was observed. Further, there was a slow regression of the process, but to the 16th session, full resolution was not yet observed. The patient was discharged for family reasons with a diagnosis of regressing psoriasis.
A similar method can be cured and eczema, conglobata acne, pyoderma, which is checked for patients.
The advantage of the method of treatment is the shortening of the treatment period and the prolongation of the period of remission. (56) New Eng. J. Med. V. 316 N 6. pp. 297-303. Edelson R et all 1987.
CLAIM
METHOD FOR TREATMENT OF PSORIASIS AND NEURODERMITHE with the help of psoralen and subsequent irradiation, characterized in that, in order to shorten the duration of treatment and prolong the period of remission, psoralen is irradiated beforehand, with a course of treatment of 10-12 days, a dose of 1 mg per reception.
print version
Date of publication 01.04.2007гг
Comments
When commenting on, remember that the content and tone of your message can hurt the feelings of real people, show respect and tolerance to your interlocutors even if you do not share their opinion, your behavior in the conditions of freedom of expression and anonymity provided by the Internet, changes Not only virtual, but also the real world. All comments are hidden from the index, spam is controlled.