INVENTION
Russian Federation Patent RU2081636

METHOD CORRECTION PARAMETERS OF IMMUNITY

METHOD CORRECTION PARAMETERS OF IMMUNITY

Name of the inventor: Khvorostov Sergey
The name of the patentee: Khvorostov Sergey
Address for correspondence:
Starting date of the patent: 1996.06.25

Application: The invention relates to medicine, particularly to immunology, due to the influence of some parameters of immunity. The essence consists in a method of correction parameters immunity by electric current, wherein the exposure is carried out from inside the body electrical signal pulse shape of the movable current source on the nerve endings located in the gastrointestinal tract, tissues and the environment with an amplitude of not more than 50 mA at a frequency of 4 Hz to 40 MHz, twice at an interval of 15 days.

DESCRIPTION OF THE INVENTION

The invention relates to medicine, particularly to immunology, due to the influence of some parameters of immunity. May find application in the treatment of diseases associated with immune disorders, allergies and asthma, including, for activation of cellular immunity elements in operators test aircraft profile and others.

Disorders of the immune system are the basis of many diseases.

Currently, for the correction of immunity using various drugs affecting the mechanisms of cellular and humoral immunity. As immunnostimulyatorov, in particular, using extractive preparations of the thymus gland (timalin, taktivin, Timoptin, vilozen).

From synthetic immunnostimulyatorov widely known levamisole (Mashkovskii MD Drugs hours. II, Vol. 12, M. Medicine, 1993, pp. 192-203).

However, drugs that stimulate the immune processes have a number of side effects and may cause adverse reactions. So, with repeated use of several drugs may experience headache, sleep disturbance, increased body temperature, changes in sense of taste, allergic skin reactions, etc.

There is a method of electrotherapy using mesodiencephalic modulation (MDM), at which the selective activation of the central regulatory systems (gipotalyamogipofizarnoy adrenal, opioid, and others.) And improvements in cellular and humoral immunity by exposure to specially selected weak electrical signal to median brain structures. When used MDM specific impulse currents of low frequency and the primary influence on the subcortical-stem parts of the brain (Mesodiencephalic zone). For this purpose, the pulse currents applied mainly rectangular shape in a narrow frequency range of 60-90 Hz with a maximum at a frequency of 77 Hz and a duration of 3.0-5.0 ms, 0.5-4.0 mA amplitude. Used and pointed, two-phase and high-frequency filling 10000-160000 Hz electrical signals. The mechanism of action of MDM is to increase the concentration in the peripheral blood of opioid peptides (in particular beta-endorphin), pituitary hormones (eg growth hormone), insulin, and in the modulation of the concentrations of the feedback system AKGG and cortisone in the improvement of cellular and humoral immunity . Apparently influenced by MDM arise generalized correlation neuroendocrine changes in the multilateral regulatory structures. Mesodiencephalic modulation (MDM) in treatment of patients Guidelines. Approved the chief medical management of Moscow, 1993, M. p. 21-24).

However, the method of electrotherapy with the use of MDM is designed mainly for the relief of pain, accelerate healing processes in case of damage of different tissues (wounds, burns, ulcers of the stomach), and activation and immune responses and nonspecific defense mechanisms in terms of health care institutions.

The aim of the invention is to exercise influence on the parameters of immunity not only in terms of health care institutions, but at home easier and more convenient way without unpleasant sensations (tingling, burning sensation) in the area of ​​the electrodes is often experienced by patients during sessions MDM.

It is proposed as a means for correcting the immunity autonomous electrostimulator of gastrointestinal tract and mucous membranes (gastrointestinal and CO NPP).

To study the influence of the autonomous electrostimulator on some indicators of immunity conducted clinical trials in patients with atopic asthma with hypersensitivity to household and pollen allergens. The patients were in the period of drug remission maintenance therapy with bronchodilators and anti-inflammatory drugs (INTA, tayled, inhaled steroids). Therapy with electrostimulator included in the set of conventional therapy intake (by ingestion) of two capsules electrostimulator with a break of two weeks. Exposure was carried out electric current from the movable current source with an amplitude of 50 mA and a frequency of 40 Hz to 4 MHz. Before and after therapy in patients with a detailed study of respiratory function, bronchial hyperreactivity was assessed, produced klinikolaboratornye standard and special studies. Long-term effects of therapy were evaluated at 8 weeks after cessation of treatment on clinical characteristics and parameters of external breathing. Jg IgE content was determined by enzyme immunoassay. The content of immunoglobulin G, A, M radioimmunodiffuziey determined by Mancini, circulating immune complexes (CIC) and precipitation by PEG Hashkovoy.

The standard views on the effectiveness of the treatment of asthma include: improvement of bronchial conductivity, defined clinically and spirogram; the number, severity and duration of asthma attacks; volume carried bronchodilator therapy and reduce the need of anti-inflammatory steroid and non-steroidal drugs. With the improvement of the immunological point corresponds to a decrease level Jg E, increased Jg A.

Carrying out a course of therapy using the electrostimulator has led to an improvement in clinical status of patients is to reduce the response to non-specific stimuli (smells, temperature difference), in derogation of bronchodilators or anti-inflammatory drugs (30% of patients). The therapeutic effect remains long, is not less than 8 weeks after cessation of treatment. A substantial reduction of the bronchi hyperresponsiveness in 100% of patients, defined in the provocation test with acetylcholine. Before treatment all patients with bronchial critical conductivity decrease by 20% was achieved at the first dilution of acetylcholine (1: 1000). After treatment, the conductivity decrease bronchial stimulants for the first dilution was 12.6% and on the second (1: 100), 23.2% that is the maximum threshold has been reached on the acetylcholine concentration 10 times higher than before the treatment. This is a reflection of changes in the number and / or affinity to acetylcholine receptors on bronchial epithelium and effector cells.

The change of physiological parameters characterizing lung function, shows that the total volume change (the FVC) and speed (all the rest) performance before and after the application of the NPP only shows a clear trend of growth. The vast majority of the use of the stimulant causes a significant improvement in breathing performance. For some patients patency bronchi increased by more than 100% This shows the influence of a stimulant on the bronchial tubes contractility and may affect the mechanisms of bronchospasm, for example, at the level of perception of receptor stimulation.

No adverse side effects were observed.

Electrostimulator therapy showed significant and substantial decrease in Jg E serum. The vast majority of patients (75%) decreased the number Jg E, 30% more than 2-4 times. This shows a decline in the intensity of allergic inflammation. In bronchial asthma synthesis Jg E antibodies is performed primarily in the mucosa of the respiratory route and in the regional lymph nodes, where Jg predecessors E-synthesizing B cells undergo differentiation stage, getting Jg E receptors in addition to Jf M receptors, present in all types of lymphocytes. Reduced production level Jg E-antibodies indicates suppressiyu immune response. A possible mechanism for this effect is the effect on B cells of lymph nodes of the electromagnetic field bowel low frequency generated electrostimulator. The high biological activity of such fields is known.

Revealed at the same time a significant increase in the majority of patients Jg A detention indicates stimulation of immunological defense mechanisms, especially the protection of mucous membranes, where Jg A plays a leading role.

Of particular interest is identified peripheral blood eosinophil dynamics under the influence of nuclear power plants. Eosinophils form cell infiltration of airway mucosa and are the main source of a number of mediators that induce bronchospasm and edema of the bronchial mucosa, stimulate mucus secretion, damage bronchial epithelium peroxy emit toxic metabolites. Eosinophils circulate in the blood and penetrate into the tissue, they are localized in the submucosa, including the respiratory tract. Consequently, revealed a significant and reliable reduction of eosinophils in the blood indicates the influence of a stimulant to the important pathogenetic mechanisms of bronchial asthma.

Based on these results we can assume the following explanation of the therapeutic effect of AES GIT and CO in patients with bronchial asthma. Low-frequency electromagnetic field created by NPP affects numerous intestinal lymph nodes, where the differentiation of B cells and synthesis of antibodies Jg E major mechanism of allergic asthma. In parallel with the decrease Jg E synthesis is an increase in the synthesis of Jg A (values ​​correlated) that stimulates the immunological defense mechanisms of the mucous. Anti-nuclear action entails a reduction in bronchial reactivity to specific and nonspecific stimuli. In addition, nuclear power plants, as any electrical, acting at the level of the hypothalamic-pituitary system, enhancing the production of hormones with anti-inflammatory effects, which reduce the number or affinity of cholinergic receptors on bronchial epithelial surface membrane or cytoplasmic effector cells. It consequently reduces the likelihood of perception of the external stimulator, after this reduction decreases the frequency and severity of attacks of breathlessness.

Studies have been conducted to assess the possibility of using the electrostimulator for the activation of cellular immunity elements aviation operators under the profile of the flight simulation stressful labor factors.

Subjects without diagnoses (practically healthy) NPP taken twice at an interval of 15 days. Before and after the use of nuclear power plants conducted a comprehensive survey, providing an assessment of the subjective state, including with the use of immunological tests.

As immunological tests used a technique based on the study of receptor system of basic cell populations of T-lymphocytes (T-active, T-shared cells, T lymphocytes enriched helper functions), responsible for cell-mediated immunity (tests rosette on K.A.Lebedevu and I.D.Ponyakinoy, 1990). All immunological studies were performed in trace peripheral blood.

The results of immunological tests demonstrate the positive impact of the NPP on the activation of cells of cellular immunity, which is manifested in the prevalence of the blood fractions the most functionally active lymphocytes (T-active). Thus, in 67% of test-common attitude T lymphocytes to T-cells, the active value was less than unity, reflecting the effect of the mobilization of the receptor structures of the cell membrane of T lymphocytes and could indicate a certain immunopotentsiruyuschem NPP effect.

These results suggest a possible strengthening of the immune potential of the blood after administration of the NPP as a prophylactic measure. Apparently cleansing the body of toxins leads at some point to an increase in blood levels of certain metabolites and altered cellular markers that can be seen as the start of the mechanism of the observed changes in blood test. Differences in the degree of antigenic load on the body before and after the nuclear power plant are decisive moments and in the characterization of multi-dimensional physiologically sound effects on endogenous electrical performance immunogram test.

The proposed method of influence on immune parameters may find application in the treatment of diseases associated with immune disorders, such as allergic and bronchial asthma including for activation of cellular immunity elements in operators, test aircraft and other profile.

CLAIM

Method immunity correction by exposing the electrical signal pulse shape, characterized in that the source of the electrical signal of pulse form are administered into the body orally and then act on the nerve endings are located in the digestive tract, an electrical signal of pulse shape with a current amplitude of 50 mA at a frequency 4 Hz to 40 MHz, while the action is carried out by the introduction of the source of electrical pulse waveform in the digestive tract prior to its removal from the body naturally, the source of pulse-shaped electric signal is introduced into the body twice at an interval of 15 days.

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Publication date 02.04.2007gg