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INVENTION
Patent of the Russian Federation RU2286185
METHOD FOR TREATMENT OF CARDIOVASCULAR DISEASES
The name of the inventor: Parshina Svetlana Serafimovna (RU); Kirichuk Vyacheslav Fedorovich (RU); Tupikin Vladimir Dmitrievich (RU); Golovacheva Tatiana Vladimirovna (RU); Alexander Krencitsky (RU); Mayborodin Anatoly Viktorovich
The name of the patent holder: Open Joint-Stock Company Central Scientific Research Institute of Measurement Apparatus (CNIIIA)
Address for correspondence: 410012, Saratov, ul. Moscow, 155, SSU, PLO, Pat. NVRomanova
Date of commencement of the patent: 2005.02.14
The invention relates to medicine, namely cardiology, and concerns the treatment of cardiovascular diseases. Affect the patient with electromagnetic radiation millimeter range at the frequencies of the molecular spectrum of radiation and absorption of nitric oxide in the regime of interruption of radiation during the session, with the localization of irradiation in the area of the xiphoid process of the sternum. The method allows to achieve a more pronounced anti-anginal action and an increase in the fibrinolytic properties of the blood on the background of ongoing medical therapy.
DESCRIPTION OF THE INVENTION
The invention relates to medicine, in particular to cardiology, and can be used to increase the antianginal effect of treatment and increase the fibrinolytic activity of blood in patients with cardiovascular diseases, in particular stable and unstable angina, including with concomitant arterial hypertension (primary or secondary).
There are known medical methods for the treatment of angina pectoris, in which, as a rule, nitrates, beta-adrenoblockers, aspirin, and others are used.
One such treatment includes intravenous drip of nitroglycerin and one of the vasodilator prostaglandins, for example the prostenone, simultaneously. The administration of the drugs is carried out until a therapeutic effect is achieved. The positive effect: prevention of refractoriness of the patient to the action of nitrates, a decrease in the risk of developing myocardial infarction, a reduction in the duration of the attack of angina, a reduction in the duration of treatment of patients in hospital settings (see RF patent No. 2072842, IPC A 61 K 3 1/21).
However, such methods are not effective enough.
A method for the treatment of coronary heart disease is known, in which the electromagnetic radiation of the EHF-range is applied to acupuncture points. The frequency of emissions is selected individually from the range of 60.9-61.2 GHz. To do this, checkpoints of meridians C and MC are studied using the R. Voll method. The course of treatment is 10-12 procedures (see RF patent No. 21744417, IPC A 61 N 5/02).
A method of bioresonance therapy with low-intensity electromagnetic fields (EMF) of extremely high frequencies (millimeter wave band) is known in the treatment of human diseases (see the Provisional Instruction of the Ministry of Health of the USSR approved on 18.07.1986). This method is affected by the radiation from the EHF generator (G4-142), which provides an output power of up to 8 mW / cm 2 at frequencies of 50-70 GHz, acting in zones characteristic of acupuncture. In this case, the radiator (antenna) is fixed at a distance of 5 cm from the irradiated area of the body surface, and the area of the irradiated area should be about 2 cm 2 . The duration of the procedure is 20-25 minutes, and the whole course of treatment is 10-15 sessions (with interruptions).
These methods are more effective in comparison with conventional medicamentous, but also insufficiently effective in the treatment of cardiovascular diseases.
The method closest to the proposed solution is the way to treat angina pectoris by exposing the patient to electromagnetic radiation of millimeter range (EMR MMD or EHF-therapy). With the initial decrease in anticoagulant and increase in procoagulant potentials of blood, as well as activation of intravascular coagulation, the wavelength is 7.1 mm in irradiation mode "5/10" (5 minutes irradiation, 10 minutes break). With the initial oppression of anticoagulant and fibrinolytic activities of blood, the wavelength is 5.6 mm in the "2/5" mode (2 minutes irradiation, 5 minutes break). With the initial decrease in anticoagulant and fibrinolytic abilities of blood and a simultaneous increase in the procoagulant potential, the wavelength is 5.6 mm in the "2/5" mode (see RF patent No. 2086269, IPC A 61 N 5/02).
Electromagnetic radiation in the millimeter range (EMR MMD or EHF-therapy) has been used in cardiology for 15 years and the effects of EMR MMD 
= 7.1 mm and = 5.6 mm have been studied quite well (see, for example, Parshina SS Influence of millimeter-wave electromagnetic radiation on the functional state of the hemostatic system in patients with angina pectoris: Author's abstract of Candidate of Medical Science - Saratov, 1994. - 28 sec. .).
However, in some patients, the antianginal effect is not sufficiently pronounced.
The objective of the proposed solution is to increase the effectiveness of treatment by increasing the antianginal effect and increasing fibrinolytic activity of the blood.
This object is achieved by the fact that in the method of treating cardiovascular diseases involving the patient with electromagnetic radiation of millimeter range, according to the invention, the effect is performed at the frequencies of the molecular spectrum of radiation and absorption of nitric oxide in intermittent mode when the irradiation is localized in the region of the xiphoid process of the sternum.
The exposure regimen is chosen as follows: 2 min irradiation, 5 min break or 3 min irradiation, 15 min break with a session duration of 37 or 39 minutes, respectively. Irradiation is carried out in an amount of 8-10 sessions per session per day.
The method consists in the following: on the background of the generally accepted drug therapy for patients with cardiovascular diseases, in particular stable and unstable angina, including those with concomitant arterial hypertension (primary or secondary), EMD MMD is treated in an amount of 8-10 sessions at the frequencies of the molecular spectrum Radiation and absorption of nitric oxide (150, 176 ... 150, 644 GHz) during 37-39 min in the intermittent mode of signal generation (2 min irradiation, 5 min break or 3 min irradiation, 15 min break) with localization of irradiation in the region The xiphoid process of the sternum, with an output power of 500 μW, a distance between the center of the radiator and the object of 4 cm, and a power density of EMR on the skin surface of 17.4 μW / cm 2 .
The power density of the EMR EHF is determined from the relation:
= P (μW) / S 1 (cm 2 ),
Where P is the radiation power at the output of the radiator;
S 1 - area of the irradiated surface;
wherein
D 0 is the diameter of the diaphragm of the radiator;
L is the distance between the center of the radiator and the object;
D 1 is the diameter of a circular beam at a distance l.
Nitric oxide is not only a universal regulator of physiological and metabolic processes in a single cell and in the body as a whole, but also performs intercellular interactions, functioning as a signal molecule in virtually all organs and tissues of humans and animals (Markov, NM Nitric oxide and carbon monoxide - a new class of signaling molecules / / Successes of physiological sciences - 1996 - T.27 - №4 - P.30-44, Snyder S.Kh., Bredt DS Biological role of nitric oxide // In the world of science - 1992 - № 7 - C.15-24, Moncada S., Palmer RU, Higgs EA Nitric oxide: physiology, pathophysioldgy and pharmacology // Pharmacol. Rev. - V.43 - P.109-142).
The molecular spectrum of emission and absorption of nitric oxide (150, 176 ... 150, 644 GHz) is in the short-wave part of the submillimeter band, commonly called the terahertz (THz) band, which is located on the scale of electromagnetic waves between EHF and optical infrared ranges.
Nitric oxide NO as an exogenous vasodilator is involved in the regulation of the tone of blood vessels (see Menshikova, EB, Zenkov, NK, Reutov, VP, Nitric oxide and NO-synthase in mammals under various physiological conditions, Biochemistry 2000 - т.65, вып.4 - С.485-503, Severina IS Soluble Gunylate Cyclase in the Molecular Mechanism of Physiological Effects of Nitric Oxide - Biochemistry, 1998 - v.63 - N7 - P.939-997) and is considered Now as a powerful antihypertensive factor, inhibits the aggregation of platelets, thereby affecting one of the leading links in the pathogenesis of coronary heart disease - the state of the hemostatic system.
We have first proposed a method for treating cardiovascular diseases using the influence of electromagnetic radiation in the millimeter range at the frequencies of the molecular spectrum of nitric oxide (EMR MMD-NO or EMR EHF-NO).
The study of the interaction of EMR EHF-NO with the human body was carried out in stages:
I stage: study of the influence of EMR EHF-NO in healthy volunteers.
II stage: the study of the effects of EMP on the frequencies of the molecular spectrum of nitric oxide in people with a history of cardiology in which the disease was at the stage of remission at the time of the study.
Stage III: study of the effect of EMR EHF-NO in patients with cardiovascular pathology who were on treatment in the cardiological department of the hospital. This group included patients with stable and unstable angina at different periods of inpatient treatment with concomitant arterial hypertension (primary or secondary), and patients with primary hypertension (hypertensive disease) in whom EMI EHF-NO was used to arrest hypertensive crises.
Irradiation of EMR MMD-NO was carried out with the help of a small-sized "KVCH-NO" generator. The structure of the molecular spectrum of nitric oxide (150, 176 ... 150, 644 GHz) is formed by this generator in accordance with the methods proposed and implemented in the quasi-optical EHF generator complex of deterministic noise modeling for biophysical studies. The localization of irradiation is the area of the xiphoid process of the sternum. The output power was 500 μW, the distance between the center of the radiator and the object was 4 cm, while the power density of the EMR on the surface of the skin was 17.4 μW / cm 2 . Before, during and after the session, blood pressure (BP), heart rate (Ps) were measured, subjective sensations of subjects were carefully recorded.
The results of the study showed that the use of EMR EHF-NO in some healthy volunteers causes a number of vegetative reactions, and these reactions are recorded predominantly in women and occur in the first 3-4 min of irradiation, which, firstly, may indicate the presence of different sensitivity to EMR EHF-NO, and secondly, the effect of this type of millimeter radiation on the state of the autonomic nervous system.
Further, the effect of EMR of EHF-NO on the condition of patients with various pathologies of the cardiovascular system in the anamnesis was studied, the disease of which was in stable remission for at least 3-4 years. Variations in hemodynamic parameters were noted: changes in blood pressure by 9-18%, pulse rate by 8-12%. At the same time, the ECG in patients with IHD showed no negative dynamics in the ST segment and the T wave, which led to the next stage - the use of terahertz band waves at the frequencies of the molecular spectrum of nitric oxide in the clinic.
Taking into account the data obtained during the first and second stages of the study, namely, the appearance of various reactions during the session for 3-4 min of irradiation, we chose intermittent ones, the "2/5" (2 min irradiation, 5 min break, the total duration of the session 37 min) and "3/15" (3 min irradiation, 15 min break, the total duration of the session is 39 min).
Patients with stable and unstable angina, including those with concomitant arterial hypertension (30 people) received standard medical therapy with aspirin, heparin, nitrates, 
Adrenoblockers, ACE inhibitors and other drugs as needed. Against this background, he was treated with EMR EHF-NO as described above. The course of treatment included 10 procedures.
The effectiveness of treatment of patients with angina pectoris with the use of EMR EHF-NO was evaluated by the antianginal effect, the effect on the parameters of the hemostasis system as one of the leading links in the pathogenesis of coronary heart disease, the change in hemodynamic parameters, Dopoechocardiography.
The antianginal effect was assessed as follows: excellent - complete disappearance of angina attacks, good - reduction of the functional class of angina pectoris, cessation of progression, satisfactory - decrease in the amount of nitroglycerin consumed and decrease in angina attacks while maintaining the original functional class.
In all patients, the treatment resulted in a positive antianginal effect. 66.7% of patients had no angina at the time of discharge, 35.7% remained single with moderate physical exertion and were self-sufficient. At discharge patients did not use nitroglycerin. None of the patients showed any worsening of the condition or development of any complications.
None of the patients had a rhythm disturbance, hypertensive crises, or angina attacks during or after EMR EHF-NO sessions.
The dynamics of blood pressure during the sessions was varied: in 75% of patients there was a decrease in BP both systolic and diastolic blood pressure by 5-20 mm Hg. During the first 2 minutes of irradiation. In the future, blood pressure increased slightly, but by the end of the session it still remained at lower digits than the original one. The remaining 25% of patients had no BP in the first 4-5 sessions of such dynamics, but later the hypotensive effect of EMR of EHF-NO and BP at the end of the session decreased compared to the initial one. The following fact deserves attention: at an initially low diastolic blood pressure (in a patient with unstable angina, uncontrolled arterial hypertension and severe aortic stenosis), during the exposure to EMR of EHF-NO, an increase of 10-30 mm Hg was noted. In combination with a decrease in systolic blood pressure (for example, with the initial blood pressure of 130/43 mm Hg, it was noted that it changed to 111/75 mm Hg during the session). The fluctuations in the pulse rate during the sessions and were varied: it was noted as an increase of 7-10%, and a decrease of 12-16%. In no case was the development of bradycardia less than 60 beats / min, or the appearance of tachycardia more than 90 beats / min.
It was found that the use of EMR EHF-NO allows to achieve a more pronounced antianginal effect in comparison with EMR of MMD of standard wavelengths (7.1 and 5.6 mm) (Table 1). So, statistically significantly more (almost 2 times) marked an excellent antianginal effect. Attention is drawn to the fact that in the treatment of EMI EHF-NO, its antianginal effect was recorded in all patients (ie, in 100% of cases), while in the group of patients treated with EMR EHF of standard wavelengths (7.1 and 5.6 Mm), in 6.4% of cases it was not possible to achieve a positive antianginal effect.
A comparative analysis of the antianginal effect of EMR EHF-NO and EMR of EHF of standard wavelengths (7.1 and 5.6 mm) revealed and its faster achievement with EMR EHF-NO (Table 2)
Thus, with the use of EMR EHF-NO for 7-8 sessions, the antianginal effect was manifested (at different rates) in all patients, whereas in the treatment of EMR of MMD of standard wavelengths (7.1 and 5.6 mm) in 8.7% of patients, the antianginal effect was manifested 9-10 sessions, and in 2.2% of cases even delayed (after the termination of the course of EMR EHF) effect was observed.
The positive effect of EMR of EHF-NO on the state of the hemocoagulation system was noted: lengthening of clotting time, activated partial thromboplastin time and decrease in the level of fibrinogen during discharge from the hospital were noted.
Analysis of the effect of EMR of EHF-NO on the functional state of the hemostasis system showed that this type of EM of the millimeter range exerts a pronounced effect primarily on the fibrinolytic link of hemocoagulation (Table 3). At the same time, the increase in fibrinolytic blood potential was more significant in comparison with the results of treatment of EMR MMD of standard wavelengths (7.1 and 5.6 mm).
Thus, EMR EHF-NO has more pronounced antianginal and profibrinolytic action in comparison with EMR of MMD of standard wavelengths (7.1 and 5.6 mm).
Clinical example: patient A., 68 years old, was on inpatient treatment since 8.06.04 with the diagnosis:
Main: 1. IHD. Unstable Angina IIIB according to Braunvald. Stenocardia of tension IV f.k. From 16.06.04. Postponed myocardial infarction in 2002, 2003 Combined aortic defect with prevalence of severe stenosis of atherosclerotic origin. Arterial hypertension III, risk IV.
2. Chronic pyelonephritis in the acute stage. Accompanying: Chronic calculous cholecystitis in st. Remission. Varicose veins. Complications: NK I, IIIF by NYHA. Supraventricular, ventricular extrasystole in the anamnesis.
Therapy of EMR EHF-NO was started on the 12th day of treatment due to the ineffectiveness of the medication being administered. The patient had angina attacks with little physical exertion (walking along the corridor) and at rest, fluctuations in blood pressure to the degree of hypertensive crises, took up to 10-15 tab. Nitroglycerin per day. Despite the correction of drug treatment (the patient received nitrates - monoquinque 1 t. 2 times a day, calcium antagonists, ACE inhibitors, aspirin, polarizing mixture and isocaine IV drip, diuretic, antibiotics), the condition continued to be severe.
After the start of EMR EHF-NO for the 4th session, there was an improvement in the condition: during the day, angina attacks significantly worsened (1-2 times a day), blood pressure was stopped. Hypertensive crises persisted at night, against which angina attacks recurred. By the 8th session, combined with medical and EHF-therapy, NO, the patient's well-being improved significantly, hypertensive crises ceased at night, angina episodes completely disappeared. The level of fibrinogen decreased as a result of treatment from 4.5 g / l to 3.25 g / l. It is written out without attacks of a stenocardia, with stable figures of a BP, nitroglycerinum did not use.
This observation indicates the effectiveness of EHF-therapy-NO in a patient with severe CHD in combination with a pronounced impairment of central and peripheral hemodynamics as a result of severe aortic stenosis and arterial hypertension.
In addition to the use of EMR EHF-NO in unstable angina, terahertz radiation at the frequencies of the molecular spectrum of nitric oxide was used in patients with primary arterial hypertension (hypertensive disease) for the management of hypertensive crises.
Clinical observation: patient K., 41 years. He suffers from hypertension for 10 years, was repeatedly on outpatient and inpatient treatment. It takes atenolol 25 mg / day. EMR EHF-NO was used to arrest the hypertensive crisis with an initial BP of 180/110 mm Hg. The initial pulse rate is 82 bpm. The continuous exposure procedure was used for 6 min. On the 2nd minute of irradiation appeared discomfort in the back parts of the neck in combination with a minor stitching pain of the same localization. At the 3rd minute BP decreased to 150/100 mm Hg, for the 4th minute BP 160/110 mmHg, pulse 91 in min, for the 6th minute of the irradiation AD 160/110 mm Hg. St., Pulse 83 per minute. After the end of the session for the first minute, there was an improvement in vision: the clarity of perception and the brightness of the colors increased, by the 5th minute there were unpleasant sensations in the posterior parts of the neck, the BP was preserved on the figures 160/110 mm Hg, pulse 84 in min. By the 15th minute of recovery of blood pressure 140/100 mm Hg, pulse, 84 per minute, there are no unpleasant sensations.
The described observation indicates that EMR EHF-NO is a potent vasodilating factor and can be used in the complex treatment of patients with angina with concomitant arterial hypertension for relief of hypertensive crises.
Thus, the electromagnetic radiation of the terahertz range at the frequencies of the molecular spectrum of nitric oxide is a theoretically and experimentally grounded method for treating patients with cardiovascular pathology. The promise of this new direction - "terahertz therapy" - is confirmed by the first results of EMR EHF-NO application in the clinic.
CLAIM
A method for the treatment of cardiovascular diseases comprising exposing a patient to electromagnetic radiation in millimeter range, characterized in that the effect is performed at the frequencies of the molecular spectrum of radiation and absorption of nitric oxide when the irradiation is localized in the region of the xiphoid process of the sternum, the effect being performed in the mode of interrupting radiation During the session.
2. A method according to claim 1, characterized in that the treatment mode is selected as follows: 3 min irradiation, 15 min break with a session time of 39 min.
3. The method of claim 1, wherein the exposure regimen is selected as follows: 2 min irradiation, 5 min break with a session duration of 37 min.
4. A method according to claim 2 or 3, characterized in that the irradiation is carried out in an amount of 8-10 sessions per session per day.
5. The method of claim 1, characterized in that it is operated at an output power of 500 μW and a radiation power density on the skin surface of 17.4 μW / cm 2 , with the distance between the center of the radiator and the object being selected to be 4 cm.
6. The method of claim 1, wherein the irradiation is performed against the background of conventional drug therapy.
print version
Date of publication 06.01.2007gg
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