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INVENTION
Patent of the Russian Federation RU2082381
METHOD OF TREATMENT OF PERSONS RECEIVED BY IRRADIATION BY SMALL DOSES OF IONIZING
RADIATIONS WITH ASTHENO-NEUROTIC SYNDROME IN CONNECTION WITH
VEGETA-VASCULAR DYTONY
The name of the inventor: Gogilov NP
The name of the patentee: Sochi Scientific Research Institute of Balneology and Physiotherapy of the Ministry of Health of the Russian Federation
Address for correspondence:
Date of commencement of the patent: 1993.12.26
(EN) The invention relates to medicine, namely, neurology and balneology, and can be used in persons who received irradiation with small doses of ionizing radiation in combination with vegeto-vascular dystonia.
SUMMARY OF THE INVENTION: after minimal adaptation, the patient is assigned hydrogen sulphide baths in the regime of stepwise-increasing concentration of hydrogen sulfide 25-50-100-150 mg / l at the exposure time of 6-8-10-12-15 minutes in combination with irrigation of the head with hydrogen sulfide water on the day of administration Baths, after 30 min rest, at the concentration of hydrogen sulfide in the first five procedures of 100 mg / l, 10 min, the following five procedures with the concentration of hydrogen sulfide 150 mg / l, 10 min, for a total of 10 procedures.
DESCRIPTION OF THE INVENTION
The invention relates to medicine, namely, neurology and balneology.
Methods of treating neuroses, neurasthenia with various syndromes, and disorders of central hemodynamics are known.
However, the known methods do not give the desired result of treatment, since the treatment is long, and the terms of remission are small. [1]
The aim of the invention is to shorten the duration of treatment and to prolong remission.
The goal is achieved by the fact that after minimal adaptation, the patient is prescribed common hydrogen sulphide baths in a stepwise-increasing concentration regime from 25-50-100-150 ml / l of hydrogen sulfide at an exposure time of 6-8-10-12-15 min combined with irrigation Head with hydrogen sulfide water on the day of taking baths, after 30 minutes rest, at the concentration of hydrogen sulfide: the first 5 procedures 100 mg / l, at a time of 10 minutes N 5. Then, the following five procedures for head irrigation are carried out at a hydrogen sulfide concentration of 150 mg / l for 10 minutes. A total of 10 courses a day.
THE METHOD IS PROVIDED AS FOLLOWS:
After minimal adaptation of the patient at the resort, from the second day, hydrogen sulphide baths are prescribed every other day for a course of 10 procedures with the concentration of hydrogen sulphide: the first two procedures in 25 mg / l, duration of 6.8 minutes; The third and fourth procedures are 50 mg / l, lasting 10 minutes, 12 minutes; Fifth and sixth procedures of 100 mg / l, duration of 15 minutes; The seventh - the tenth procedure of 150 mg / l, the duration of 15 minutes.
In the days of taking common hydrogen sulphide baths, 30 minutes after the release of the common bath, the head is hydrated with hydrogen sulfide water: the first five procedures are released at a hydrogen sulphide concentration of 100 mg / l for 10 minutes. From the sixth procedure, head irrigation is carried out at a hydrogen sulfide concentration of 150 mg / l, lasting 10 minutes, for a total of 10 irrigation courses.
Example 1
The patient is 39 years old. Was in the clinic of the Institute, in the neurology department from 2.07.92 to 27.07.92. I was diagnosed with: Vegetative-vascular dystonia with astheno-neurotic manifestations. At admission I complained of weakness, quick fatigue, irritability, short temper, instability of mood; Anxiety, headache, dizziness after overwork, sleep disorder, pain in the heart after nervous and emotional overload, pain in the lumbar spine.
The patient took part in the liquidation of the accident at the Chernobyl nuclear power plant in 1986, was in the radioactive contamination zone for 2 months. The radiation dose is 24.5 Beer.
After returning from Chernobyl, the patient noted increased weakness. In 1988, complaints of nervous system disorders appeared, followed by headaches, a feeling of heaviness in the occipital part of the head, and occasional dizziness. I was treated out-patient about astheno-neurotic syndrome: general restorative therapy, vitamins, biostimulants, sedatives. Later, he was registered as a "liquidator" of the Chernobyl accident. Outpatient treatment was conducted up to 2 times a year. Previously, sanatorium treatment was not accepted.
DATA OF OBJECTIVE RESEARCH
The patient's condition is satisfactory, his physique is of the normostenic type. Skin and visible mucous membranes are clean, pale pink, subcutaneous fat is moderately developed. Lymph nodes are accessible for palpation, not enlarged. The border of the heart within the permissible norm. The pronounced impulse is defined in the intercostal space. Heart tones are slightly muffled not to the top, rhythmic. BP 120/60 mm Hg, pulse 68 bpm, satisfactory filling and tension. Respiratory organs within normal limits. The digestive organs are within normal limits. Nervous system: ЧМН adjusting, horizontal, small-petulant, nystagmoid in extreme leads. The sensitivity was not detected. The tendon-peristal reflexes are animated on both sides, with the extension of the zone of inertia. In the Romberg pose is stable, the finger-nasal test performs confidently. The patient is emotionally lazy, talkative. The genitourinary system is within normal limits.
DATA OF PARACLINIC METHODS OF SURVEY BEFORE TREATMENT
The general analysis of the blood: hemoglobin 147,6 g / l, erythrocytes 4,9х10 12 l, leukocytes 6,2х10 9 , lymphocytes 45, platelets 202х10 9 l, ESR 4 mm / h. Biochemical blood tests: total amount of nucleic acids 2.28; Diene conjugates of blood plasma lipids 2.22; Malonic dialdehyde of erythrocytes 31.09; Malonic dialdehyde 11.02, catalase 1.33, medium molecular peptides 0.222.
ECG: rhythm sinusovy 58 beats per minute, sinus bradycardia. Moderate changes in the myocardium.
REG: Blood supply to the brain in the pool of internal carotid arteries is strengthened. The tonus of the arteries is elevated. There was a tendency to obstruct venous outflow. Interhemispheric asymmetry.
Immune status: in the course of the studies, relative lymphocytosis, a decrease in the number of suppressor cells against a background of insignificant hypergammoglobulinemia of M.
Psychological tests: Taylor-37, self-assessment questionnaire-32.
In the course of the survey, a diagnosis was made: Asthenic-neurotic syndrome with vegeto-vascular dystonia.
The patient is prescribed treatment according to the proposed method:
- Climatological procedures according to the I-II regime, the physical activity is sparing, adaptation is 2, 3 days, morning and therapeutic gymnastics according to the second regime;
- Diet N 5;
- Total hydrogen sulphide baths in the regime of step-up concentration from 25-50-100-150 mg / l at the exposure time of 6-8-10-12-15 minutes (Table 1) every other day for a course of 10 procedures, irrigation of the head with hydrogen sulfide water in Days of taking baths at the concentration of hydrogen sulphide: the first five procedures are 100 mg / l for 10 minutes, then 150 mg / l for 10 minutes (starting from the sixth head irrigation procedure the concentration of hydrogen sulfide is constant 150 mg / l for 10 minutes) for a course of 10 procedures.
During the 24-day stay in the clinic, the patient was examined by a doctor 5 times. All procedures are well tolerated. The patient was discharged with the diagnosis: Asthenic-neurotic syndrome with vegeto-vascular dystonia.
In the course of treatment, the patient received a full course of planned treatment and was discharged with significant improvement, which was manifested in the disappearance of attacks of headache, dizziness, and recovery of sleep. The patient had a good rest, became more calm, balanced, pains along the course of the spine do not disturb.
DATA OF THE SURVEY AFTER TREATMENT
The general analysis of the blood: hemoglobin 123,9 g / l, erythrocytes 4,8х10 12 g / l, platelets 240х10 9 , lipids 10,0, ESR 20.
Biochemical blood tests: total amount of nucleic acids 2.28, diene conjugates of blood lipids 3.29, malonic dialdehyde of erythrocytes 53.70, malonic lipid dialdehyde 13.46 catalysis 28.21, medium-molecular peptides 0.245.
ECG: sinus rhythm. Normal position of electric. Heart. Without dynamics.
REG: blood vessels in the brain in the pool of internal carotid arteries recovered. The tonus of the arteries, the elasticity of the vessels, the venous circulation are normalized.
After the treatment, the functional mode of the functional link of humoral immunity was normalized.
In general, the positive effect of the proposed method of treatment on the patient was noted.
To assess the effectiveness of the proposed method of treatment, a comparative analysis of 2 groups of patients was carried out.
Group I of 30 patients with astheno-neurotic syndrome with vegeto-vascular dystonia phenomena developing in persons who participated in the liquidation of the Chernobyl accident, exposed to low doses of ionizing radiation and frequent stressful situations.
I group (prototype) received a complex of sanatorium treatment including general hydrogen sulphide baths + LFK + climatotherapy. By age, they were distributed as follows: from 20 to 30 years 10% of 31-40 years 40% 45-50 years 40% 51-60 years 10% All sick representatives of the male. Liquidators. The dose of irradiation in the range of 0.8-29.4 R. By the time of stay in the accident zone, the patients were distributed as follows: up to 2 months 26.6% 2-4 months 43.4% 4-5 months 30% of patients. In 1986, 36.6% in 1987, 33.4% in 1988, 30%
Group II of 30 patients, liquidators of the accident at the Chernobyl Nuclear Power Plant, received irradiation with small doses of ionizing radiation with an astheno-neurotic syndrome with the phenomena of vegetative-vascular dystonia. Accepted treatment according to the proposed method: against the backdrop of climatotherapy and exercise therapy, general hydrogen sulphide baths and irrigation of the head with hydrogen sulfide water every other day for a course of 10 procedures (treatment scheme Table 1).
By age, the patients in this group were distributed as follows: 20-30 years 3% 31-40 years 50% 41-50 years 40% 51 and above 7% All male subjects, liquidators, radiation dose 0.8-29.4 P By the time of stay in the accident zone: 1-2 months 37% 2-4 months 33% 4-6 months 30% In 1986 50% 1987 37% 1988 13%
From Table. 2 that the effectiveness of the use of common hydrogen sulphide baths in combination with irrigation of the head with hydrogen sulfide water is higher in comparison with the initial group. Reduction of complaints after treatment was 42.4% in group I, 72.1% in group II.
From the data given in tab. 3 that the effectiveness of the proposed method of treatment is higher in comparison with the initial group (I gr.), The reduction of complaints is higher: I gr. 40.3% II gr. 64%
Table 3 shows that under the influence of hydrogen sulfide balneotherapy in combination with irrigation of the head with hydrogen sulfide water (II gr.), The total amount of nucleic acids increased by 0.28 and approached the lower limit of the norm. And there was a clear decrease in the level of diene conjugates by 0.87 units. And their level reached 2.02 ± 0.79 (rel. Units), i.e. Upper border. The level of medium-molecular peptides, increased before treatment in both groups, most intensively decreased in the second group and reached the average norm limits. The level of catalysis increased to treatment in both groups, most significantly decreased in the second group with an advantage of 32.3 units. And reached the upper limit of the allowable rate.
Thus, the proposed method of treatment with the use of hydrosulphuric balneotherapy in combination with head irrigation is more effective.
Comparative characteristics of immunological parameters under the influence of 2 treatment complexes are given in Table 5.
Comparative results of rheographic data on the background of treatment in both groups are given in Table 6.
Analyzing Table 5, we come to the conclusion that hydrogen sulphide baths have a soft modulating effect, i.e. Restore immunological parameters without inducing hyperstimulation of the immune system, but the use of hydrogen sulphide water in combination with head irrigation has a stronger immunomodulatory effect, causing changes that positively influence the imbalance of the immune system. Under the influence of the proposed method of treatment, more significant activity of the quantitative link of immunity and a decrease in the index of regulation towards T-helper cells were revealed. There is an increase in T-suppressor cells aimed at suppressing excessive activity of the quantitative link of humoral immunity, as indicated by the tendency toward normalization of the absolute number of B-lymphocytes.
Comparing the results of rheographic data against the background of the treatment, it can be concluded that the most pronounced therapeutic effect was obtained as a result of the course of treatment according to the proposed method. A more pronounced (II grade) decrease in the rheographic index was observed at 5.8 cm on the right and 0.3 cm on the left, indicating a more significant decrease in the tone of the peripheral cerebral vessels compared to the first group and approaching the indices to the upper limit of the norm .
In the first group, the modulus of elastic modulus decreased by 0.6% on the right and by 0.9% on the left, while in the second group the decrease in the modulus of elasticity was more pronounced, by 3.7% on the right and by 2.7% On the left, which approximates the indicators at the upper limit of the norm.
Thus, according to the results of REG, the proposed method of treatment is more effective.
As a result of the analysis of Table. 7, we can note a higher effectiveness of the proposed method of treatment, including common hydrogen sulphide baths and head irrigation with hydrogen sulfide water, where 57% and 43% of patients discharged with slight improvement and without dynamics were discharged with significant improvement and improvement.
Thus, the proposed method of treatment of liquidators of the Chernobyl accident, exposed to small doses of ionizing radiation, in which astheno-neurotic syndrome developed, has pronounced therapeutic effects.
CLAIM
A method of treating individuals who received radiation with small doses of ionizing radiation, with an astheno-neurotic syndrome in combination with vegeto-vascular dystonia by balneotherapy, characterized by the addition of irrigation of the head with hydrogen sulfide water at a concentration of 100-150 mg / l to 10 min on the days of bathing In a day, on a course of 10 procedures.
print version
Date of publication 08.11.2006gg
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