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antivirals

The first drugs proposed as a specific antiviral agent, was K thiosemicarbazone, virulotsidnoe action is described by G. Domagk (1946).
The preparation of this group tioatsetazon (. Cm) has some antiviral activity, but is not sufficiently effective; it is used as antituberculosis agent.
A derivative of the group 1, 4-benzoquinone-guanyl gidrazinotio semicarbazone called <Faringosept> (Faringosept, Romania) is used in the form of <perlingvalnyh> (resorbable oral) tablets for the treatment of infectious diseases of the upper respiratory tract (tonsillitis, gingivitis, stomatitis and etc.).
In the future, it was synthesized Kmetisazon effectively suppresses reproduction of smallpox viruses (see.) And in 1959 g.- nucleoside K idoxuridine (cm.), Turned out to be an effective antiviral agent that suppresses herpes simplex virus and vaccinia (vaccinal disease). Side effects when administered systemically limited the possibility of wide use idoxuridine, but he remained as an effective tool for local use in ophthalmic practice for herpetic keratitis. Following idoxuridine steel receive other nucleosides have been identified among which high antivirals, including Katsiklovir (cm.) Kribamidil (Kribavirin -. Cm), and others.
In 1964 was synthesized Kamantadin (see. Midantan), then rimantadine (cm.) And other adamantane derivatives were effective antiviral agents.
The outstanding event was the discovery of endogenous interferon-K and the establishment of its antiviral activity. Modern recombinant DNA technology (genetic engineering) opened up the possibility of using a wide interferons for the treatment and prevention of viral and other diseases.
Russian researchers developed a number of synthetic and natural (herbal) medicines for systemic and topical use in viral diseases (see. Bonafton, Arbidol, oxoline, Deytiformin, Tebrofen, Alpizarin et al.).
It is now established that the effect of a number of immunostimulatory and antiviral agents (see. Prodigiozan, Poludan, Arbidol et al.) Is related to their activity interferonogenic, t. E. The ability to stimulate the production of endogenous interferon.

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