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benzodiazepine derivatives

All benzodiazepine tranquilizers groups have a greater or lesser degree of sedation and contribute to the onset of sleep. The intensity of individual parties actions (sedative, antianxiety, miorelaksantnogo et al.), Different drugs in this group differ from each other. It means providing the most pronounced hypnotic effect include nitrazepam and some new drugs (triazolam, flurazepam, temazepam, etc.).
According to the mechanism of action of benzodiazepine hypnotics mostly similar to tranquilizers of this series. They all bind to brain tissues with specific benzodiazepine receptors. Recently, these receptors are divided into two subgroups (B - B, and 1 - 2). It is believed that the hypnotic effect due to stronger binding with compounds 1-B receptors. Binding to benzodiazepine receptors is accompanied by activation of the GABA receptor (see. Aminalon), which leads to inhibition of the functional activity of CNS cells. The main value for the hypnotic effect is inhibition of the activity of the cells of the brain stem reticular activating system.