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Antiviral drugs

Противовирусные средства

Many antiviral drugs are on the register of vital and essential medicines, but they do not have proven effectiveness.

Which antiviral drugs have proven efficacy and which do not.

According to statistics, SARS occupy 90-95% of all infectious diseases. In Russia, more than 40 million people a year face these infections.

Many doctors are of the opinion that it is very easy to fight with ARI - do not interfere with the body's own efforts and do not spend money on medicines.

Which antiviral drugs have proven efficacy and which do not.

According to statistics, SARS occupy 90-95% of all infectious diseases. In Russia, more than 40 million people a year face these infections.

Many doctors are of the opinion that it is very easy to fight with ARI - do not interfere with the body's own efforts and do not spend money on medicines.

By the way, many antiviral drugs are on the register of vital and essential medicines, but they do not have proven effectiveness.

Which medications are effective against ARVI?

In our time, the only drugs with proven effectiveness of action are inhibitors of neuraminidase (a special enzyme located on the surface of the influenza virus and taking a direct part in the pathogenesis of the disease).

These drugs include oseltamivir (known under the trade name Tamiflu ) and zanamivir (also known as Relenza ). These drugs show proven effectiveness against influenza A and B viruses (Study 1 and 2 ).

Although recently the effect of these drugs is also questioned , but still there is no better alternative.

WHO 2010 studies report oseltamivir- resistant samples of the influenza virus.

The use of neuraminidase inhibitors is recommended only in cases of severe illness solely for the purpose of the treating physician. In most cases, taking antiviral drugs does not make sense, since the body's own strengths are enough to fight with ARI.

In Russia, these drugs are presented under such trade names:
Tamiflu (oseltamivir) - tablets;
Nomides (oseltamivir) - tablets;
Oseltamivir Kanon - tablets;
Relenza (zanamivir) - a powder for inhalation.

With the use of oseltamivir, nausea, vomiting, diarrhea, dizziness, insomnia, vertigo, arrhythmias, sudoras, allergic reactions, worsening of diabetes and others are possible.

Side effects of zanamivir are allergic reactions, bronchospasm, difficulty breathing, rash, hives, severe skin reactions, including erythema polymorph, Stevens-Johnson syndrome, toxic epidermal necrolysis.

Antiviral drugs without proven efficacy

Rimantadine

A drug with proven effectiveness in the past. However, at the moment almost 100% of influenza A (H3N2) and A (H1N1) virus strains are resistant to this drug.

Since 2011, its use in the US is not recommended . RAMS carried Rimantadine to "obsolete drugs with unproven efficacy."

Umifenovir

Also known as " Arbidol ", " Arpetolide ", " Arpefly ", " ORITOL NP ", " Arpetol " and " Immustat ".

Although the drug is on the list of vital and essential medicines of the Russian Federation, WHO believes that drug studies do not meet the requirements of evidence-based medicine.

The only suitable study shows that umifenovir can bind to the influenza virus, which is objectively insufficient to prove the effectiveness of the drug.

Sodium deoxyribonucleate

Also known as Derinat . It is a DNA salt that is designed to stimulate the body to fight viruses. However, there is no evidence base at all.

Ingavirin

Data on the effect of the drug are limited, contradictory and insufficiently justified.

According to Vasily Vlasov, a member of the Formulary Committee of the Russian Academy of Medical Sciences, there is no evidence of the effectiveness of Ingavirin. This drug is also not considered for treatment in any WHO publication.

IRS 19

Spray, which includes 19 types of dried microorganisms. It is called to stimulate immunity for treatment and prevention of diseases of the upper respiratory tract.

In studies in susceptible children, this drug had some efficacy, but the quality of many studies is inadequate and a more detailed study of the drug is required.

Oxolin

Old antiviral drug, which has no evidence base. Do not confuse with oxolinic acid, which has an antimicrobial effect.

Homeopathic remedies

Antiviral homeopathic preparations are a great many, the most popular of them - Anaferon , Ergoferon , Aflubin , Otsilokoktsinum and others.

Homeopathy has no proven efficacy in principle.

Interferon preparations

Interferons are a group of special proteins produced by the human body to fight viruses.

Evidence base is only for injection forms of these drugs, which are used to treat viral hepatitis, multiple sclerosis, cancer.

Local forms of interferons ( Grippferon, Viferon, Genferon and others) are not effective in the treatment of ARI and have no evidence base.

Also, prolonged use of interferons can cause symptoms similar to ARI (Study 1 and 2 ).

Interferon inductors

Amixin ( Lavomax, Tilaxin, Tiloron ) is a drug banned in the world due to serious side effects such as embryotoxicity (a study in rats) and provocation of mucopolysaccharidosis (also a study in rats). Clinical studies abroad have been discontinued .

In the CIS countries, it is actively sold and advertised.

Amizon - Ukrainian drug, according to the manufacturer's inducer of interferon, has anti-inflammatory and antioxidant activity. There are no studies of the drug's effectiveness.

Cycloferon is a drug for the treatment of acute respiratory viral infections and opportunistic diseases in HIV. Outside the countries of the former USSR is not registered, and its clinical effectiveness is not confirmed in any major international study.

Traditional antiviral agents

Studies have shown that all the usual honey, garlic, echinacea and other traditional medicine will not help in the treatment of ARVI (Study of honey , garlic , Echinacea , Chinese medical herbs ).

Conclusion, which can be done: drugs that uniquely and indisputably help with ARI, in fact, does not exist. However, in most cases the body is able to cope with infections on its own - just give it the opportunity to do it in comfort, do not waste energy on unnecessary activity, for example, on trips to the pharmacy. And in case of complications, consult a doctor.

Do not self-medicate and take care of your health.

Author: Alexey Kalik

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