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Acetylsalicylic acid (aspirin)

Аспирин - Ацетилсалициловая кислота

Acetylsalicylic acid ( aspirin , Latin Acidum acetylsalicylicum, salicylic ester of acetic acid) - a drug that has analgesic (analgesic), antipyretic, anti-inflammatory effect.

The mechanism of action and the safety profile of acetylsalicylic acid have been well studied, its effectiveness has been clinically tested, and therefore this drug is on the list of the most important medicines of the World Health Organization, as well as in the list of vital and essential medicines of the Russian Federation.

Acetylsalicylic acid is also widely known under the trademark "Aspirin", patented by Bayer.

Acetylsalicylic acid (aspirin) has been used quite successfully in pediatrics for many years with fever and inflammatory processes of the most diverse origin.

After the ability of acetylsalicylic acid to have a damaging effect on the gastric mucosa was proven, it was used more restrained, but this restraint did not particularly affect the frequency of use as an antipyretic. In the end, if at the moment the child has 39 ° C and the mother is convinced that after the medication it will become easier, then no theoretically possible stomach ulcers will be a real obstacle to the beginning of treatment.

But it turned out that the changes in the gastric mucosa and other side effects of acetylsalicylic acid (bleeding, bronchospasm) are all flowers. About berries for the first time started talking in 1963, when a very dangerous disease was described, manifested by severe brain and liver damage. This disease was called Reye's syndrome.

Reye's syndrome, Reye's syndrome (acute liver failure and encephalopathy, " white hepatic disease ") is a rare but very dangerous, often life-threatening acute condition that occurs in children and adolescents (usually aged 4-12 years) against the treatment of viral fever origin (influenza, measles, varicella) with preparations containing acetylsalicylic acid and characterized by rapidly progressive encephalopathy (due to cerebral edema) and the development of fatty liver infiltration. Rey's syndrome is accompanied by hyperammonemia, an increase in the level of AST, ALT in the serum (more than 3 times) with normal bilirubin level. At the heart of Ray's syndrome lies the generalized damage to mitochondria due to inhibition of oxidative phosphorylation and the violation of β-oxidation of fatty acids. The syndrome was first described by the Australian pathologist Douglas Raiem in 1963.

The reason for the development of Ray's syndrome has not been accurately established to date. At the same time, three groups of factors that contribute to the development of this syndrome have been identified - first, congenital metabolic disorders, and secondly, infections - more often viral (influenza, measles, chicken pox), less often bacterial (haemophilus infection type b) and , thirdly, the use of medications, most often it is acetylsalicylic acid.

The danger of Ray's syndrome is not comparable with any ulcers, bleeding and bronchospasm - even in the best resuscitation departments every second person is killed. The probability of disease is maximal at the age of 4-12 years.

Summary. The probability of developing Ray's syndrome is not high. But there is a risk. And we are talking about the fact that the use of acetylsalicylic acid against the background of viral infections in childhood can cause a deadly disease.

Hence the conclusion is unambiguous and concrete: in children under the age of 15 years to use as a self-treatment acetylsalicylic acid as an antipyretic agent is impossible.

Via Doctor Komarovsky & wiki