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Acetylsalicylic acid (aspirin)

Аспирин - Ацетилсалициловая кислота

Acetylsalicylic acid (colloquy. Aspirin ; lat. Acidum acetylsalicylicum, salicylic ester of acetic acid) is a drug that has analgesic (analgesic), antipyretic, anti-inflammatory effect.

The mechanism of action and safety profile of acetylsalicylic acid are well studied, its effectiveness is clinically tested, and therefore this drug is included in the list of the most important medicines of the World Health Organization, as well as in the list of vital and essential medicines of the Russian Federation.

Acetylsalicylic acid is also widely known under the trademark Aspirin, patented by Bayer.

Acetylsalicylic acid (aspirin) has been used quite successfully in pediatrics for many years in fever and inflammatory processes of a wide variety of origin.

After the ability of acetylsalicylic acid was proven to have a damaging effect on the gastric mucosa, it began to be used more restrained, but this restraint did not particularly affect the frequency of use as a fever-reducing agent. In the end, if it is at this moment that the child has 39 ° C and the mother is convinced that after the medication it becomes easier, so no theoretically possible stomach ulcers will be a real obstacle to starting treatment.

But it turned out that changes in the gastric mucosa and other side effects of acetylsalicylic acid (bleeding, bronchospasm) are all flowers. The berries were first talked about in 1963, when a very dangerous disease was described, manifested by severe damage to the brain and liver. This disease is called Ray's syndrome.

Rey's syndrome, Reye's syndrome (acute hepatic failure and encephalopathy, " white liver disease ") is a rare but very dangerous, often life-threatening acute condition that occurs in children and adolescents (most often at the age of 4-12 years) with the treatment of viral fever origin (influenza, measles, chicken pox) drugs containing acetylsalicylic acid, and characterized by rapidly progressing encephalopathy (due to brain swelling) and the development of fatty infiltration of the liver. Reye's syndrome is accompanied by hyperammonemia, increased levels of AST, ALT in the serum (more than 3 times) with a normal level of bilirubin. Reye’s syndrome is based on generalized mitochondrial damage due to inhibition of oxidative phosphorylation and impaired β-oxidation of fatty acids. The syndrome was first described by Australian pathologist Douglas Ray in 1963.

The reason for the development of Ray's syndrome has not been precisely established to date. At the same time, three groups of factors contributing to the development of this syndrome were identified - firstly, congenital metabolic disorders, secondly, infections are more often viral (influenza, measles, chicken pox), less often bacterial (hemophilic infection type b) and Thirdly, taking medication, most often it is acetylsalicylic acid.

The danger of Ray's syndrome is incomparable with any ulcers, hemorrhages and bronchospasms - even in the best intensive care units, every second patient dies. The probability of the disease is maximum at the age of 4-12 years.

Summary. The likelihood of Reye's syndrome is low. But there is a risk. And we are talking about the fact that the use of acetylsalicylic acid against the background of viral infections in childhood can cause a deadly disease.

Hence the conclusion is unequivocal and specific: for children under the age of 15 years, in the order of self-treatment, acetylsalicylic acid cannot be used as a febrifuge.

Via Dr. Komarovsky & wiki