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Acetylsalicylic acid (aspirin)

Аспирин - Ацетилсалициловая кислота

Acetylsalicylic acid (decomp. Aspirin ; lat. Acidum acetylsalicylicum, salicylic ester of acetic acid) - a drug that has analgesic (analgesic), antipyretic, anti-inflammatory effect.

The mechanism of action and the safety profile of acetylsalicylic acid have been well studied, its effectiveness has been clinically tested, and therefore this drug is included in the list of essential medicines of the World Health Organization, as well as in the list of vital and essential medicines of the Russian Federation.

Acetylsalicylic acid is also widely known under the Aspirin trademark, patented by Bayer.

Acetylsalicylic acid (aspirin) has been used quite successfully in pediatrics for many years with fever and inflammatory processes of a wide variety of origins.

After the ability of acetylsalicylic acid to have a damaging effect on the gastric mucosa was proved, they began to use it more restrained, but this restraint did not particularly affect the frequency of use as an antipyretic. In the end, if it is at the moment the child has 39 ° C and the mother is convinced that it will become easier after the medication, then no theoretically possible stomach ulcers will be a real obstacle to starting treatment.

But it turned out that changes in the gastric mucosa and other side effects of acetylsalicylic acid (bleeding, bronchospasm) are all flowers. They first talked about berries in 1963, when a very dangerous disease was described, manifested by severe damage to the brain and liver. This disease was called Reye's syndrome.

Reye’s syndrome, Reye’s syndrome (acute liver failure and encephalopathy, “ white liver disease ”) is a rare, but very dangerous, often life-threatening, acute condition that occurs in children and adolescents (usually aged 4-12 years) with treatment of viral fever origin (flu, measles, chicken pox) drugs containing acetylsalicylic acid, and characterized by rapidly progressive encephalopathy (due to cerebral edema) and the development of fatty liver. Reye's syndrome is accompanied by hyperammonemia, an increase in the level of AST, ALT in the blood serum (more than 3 times) with a normal level of bilirubin. Reye's syndrome is based on generalized mitochondrial damage due to inhibition of oxidative phosphorylation and impaired β-oxidation of fatty acids. The syndrome was first described by Australian pathologist Douglas Rye in 1963.

The reason for the development of Reye's syndrome is not exactly established to date. At the same time, three groups of factors contributing to the development of this syndrome were identified, firstly, congenital metabolic disorders, and secondly, infections are more often viral (flu, measles, chickenpox), less often bacterial (hemophilic infection type b) and thirdly, taking medication, most often acetylsalicylic acid.

The danger of Reye's syndrome is incomparable with any ulcers, bleeding and bronchospasm - even in the best resuscitation departments every second sick person dies. The probability of the disease is maximum at the age of 4-12 years.

Summary. The likelihood of developing Reye's syndrome is small. But there is a risk. And we are talking about the fact that the use of acetylsalicylic acid against the background of viral infections in childhood can cause a deadly disease.

Hence the conclusion is unequivocal and specific: in children under the age of 15 years, acetylsalicylic acid can not be used as an antipyretic in self-medication.

Via Dr. Komarovsky & wiki