Description of the medicine: Clomipramine (Clomipramine)
CLOMIPRAMINE (Clomipramine) *. 3 Chloro-5- [3- (dimethylamino) propyl] -10,11-dihydro-5H-dibenzo [b, f] -azepine.
Synonyms: Anafranil, Anafranil, Chlorimipramine, Hydiphen, Klomipramin, Maronil, Monochlorimipramine, Neoprex.
Available in the form of hydrochloride.
In structure, it differs from imipramine by the presence of a chlorine atom in the molecule.
By pharmacological properties it is also close to imipramine, but differs in a stronger blocking effect on the reverse neuronal uptake of serotonin (see Trazodon, Fluoxetine).
It has a pronounced timoleptic effect with a less pronounced stimulant component than imipramine.
It is used for various forms of depression, including deep, protracted forms. The effect occurs relatively quickly (on the 3rd - 5th day).
Usually prescribed at 0.025 g (25 mg) 3 times a day, if necessary, increasing the dose to 50 mg or more 3 times a day. In severe depression, 25-50 mg is injected into the vein (slowly!) - up to 200 mg. Upon reaching the therapeutic effect, they switch to taking the drug inside.
Side effects and contraindications are basically the same as for imipramine. Unlike imipramine, clomipramine usually does not increase fear and anxiety.
Method of release: capsules and tablets of 10; 25 and 50 mg, 1, 25% solution in ampoules of 2 ml (25 mg in ampoule).
Storage: List B.