Description of the medicine: Oxolinic acid (Acidum oxolinicum)
OXOLIC ACID (Acidum oxolinicum). 5, 8 - Dihydro-8-oxo-5-ethyl-1, 3-dioxolo (4, 5-d) quinoline-7-carboxylic acid.
Synonyms: Gramurin, Dioxol, Emyrenil, Gramurin, Nefroclar, Nevopax, Nidantin, Oxabid, Oxobid, Oxol, Oxolinic acid, Pietil, Prodoxol, Urbid, Uribid, Urigram, Uristatic, Uritrate, Uropax, etc.
Domestic drug dioxacin (Dioxacinum).
Fine crystalline white with a yellowish or creamy (to yellow) tint. Practically insoluble in water and alcohol.
According to the antibacterial spectrum of action, oxolinium acid does not significantly differ from nalidixic. The drug is most effective against gram-negative bacteria (Proteus, Escherichia coli, Staphylococcus aureus). It acts with the resistance of microorganisms to other chemotherapeutic drugs, with the exception of quinolones, since when using drugs of this group, cross resistance is observed.
In in vitro experiments, oxolinium acid is 2–4 times more active than nalidixic. However, oxolinium acid is more neurotoxic.
Oxalinic acid is used mainly for infections of the urinary tract: cystitis, pyelitis, pyelonephritis, prostatitis, as well as for the prevention of infection with cystoscopy, urinary tract catheterization.
Assign inside adults and children over 12 years old 2 tablets (0.5 g) 3 times a day, children from 2 to 12 years old - 1 tablet (0.25 g) 3 times a day. Take immediately after eating. The course of treatment is not less than 7-10 days (up to 2-4 weeks).
When using oxolinium acid, nausea, vomiting, diarrhea, heartburn, headache, anxiety, tachycardia are possible: sleep disturbance, weakness. These phenomena usually pass independently. However, with individual intolerance, the drug is stopped.
In connection with the stimulating effect on the central nervous system, caution should be exercised when prescribing the drug to patients with epilepsy and other diseases of the central nervous system.
Caution is needed when administering the drug to patients with impaired liver and kidney function (reduce the dose!), To the elderly.
Contraindicated during pregnancy and lactation, as well as children under 2 years.
Release form: tablets of 0.25 g in a package of 50 pieces.
Storage: List B. In the dark place.