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Description of the medicine: Ofloxacin (Ofloxacinum)

OFLOXACIN (Ofloxacinum). 9-Fluoro-2, 3-dihydro-3-methyl-10- (4-methyl-1-piperazinyl) -7-oxo-7H-pyrido / 1, 2, 3-de / 1, 4-benzoxazine carboxylic acid.

Synonyms: Tarid, Flobocin, Mefoxacin, Ofloxacin, Oflozet, Oxoldin, Tabrin, Tarivid, Viseren, Zanocin.

Crystalline substance slightly yellowish, odorless, bitter taste. It is slightly soluble in water and alcohol.

By its chemical structure, it is piperazinyl substituted fluoroquinolone with an optionally “built-in” methyl substituted oxazine core.

Like other fluoroquinolones, ofloxacin has a wide antibacterial spectrum of action. It mainly affects gram-negative bacteria. Effective against microorganisms resistant to most antibiotics and sulfonamides. It has a bactericidal effect.

Effective when taken orally. Quickly and almost completely (over 95%) is absorbed from the gastrointestinal tract, enters in high concentration in organs and tissues, as well as in sputum, saliva, bile, skin, tissue and the secretion of the prostate gland. The peak concentration in plasma is observed after 30 minutes; the half-life is about 6 to 7 hours. The drug is practically not metabolized; 75 - 90% is excreted in the urine, and even after a single dose, the drug is found in the urine within 20 to 24 hours.

Ofloxacin is used for infections of the respiratory tract, ear, throat, nose, skin, soft tissues, osteomyelitis, infectious diseases: abdominal organs, kidneys, urinary tract, prostatitis, infectious gynecological diseases, gonorrhea.

There is evidence of the activity of ofloxacin (tarid) against mycobacterium tuberculosis and the feasibility of its use in the treatment of tuberculosis.

Assign inside adults in the following doses: for infections of the respiratory tract, skin and soft tissues (wounds, boils, carbuncles, phlegmon, etc.), infectious diseases of the abdominal organs, upper urinary tract - 0.2 g (1 tablet) 2 times in a day; with infections of bones and joints - 0.2 - 0.4 g (1 - 2 tablets) 2 times a day; with urethritis and prostatitis - 0.3 - 0.4 g 2 times a day.

In severe infections of the respiratory tract and other severe infections, the dose is increased to 0.3 - 0.4 g per day.

Take tarid tablets without chewing, with a little water, before or after a meal.

Treatment, as with other chemotherapeutic drugs, is carried out until the signs of the disease disappear and in the next 2 to 3 days or more. Usually the course of treatment is 7 to 10 days. In uncomplicated cases, the course of treatment may be shorter. You can not take the drug for more than 4 weeks.

The drug is usually well tolerated. In some cases, allergic reactions are observed (skin itching, rash); possible development of edema of the face, vocal cords; anorexia, abdominal pain, nausea, vomiting, diarrhea; sleep disturbances, headache, anxiety, general depression; changes in the blood picture (leukopenia, agranulocytosis, thrombocytopenia). In rare cases, the perception of smell and taste is impaired.