Description of the medicine: Phthivazidum (Phthivazidum)
Phthivazidum (Phthivazidum). Isonicotinic acid 3-methoxy-4-hydroxybenzylidenehydrazide, or isonicotinoyl- (3-methoxy-4-hydroxybenzal) -hydrazone.
Synonyms: Ftivazidum, Vanicide, Vanillaberon, Vanizide.
Light yellow or yellow fine crystalline powder, with a faint odor of vanillin, without taste. It is very slightly soluble in water, little in alcohol, and easy in inorganic acids, alkalis.
According to chemotherapeutic properties and indications for use, it is close to isoniazid.
Compared with isoniazid, it is more slowly absorbed from the gastrointestinal tract; when applied, a slightly lower concentration of isonicotinic acid hydrazide is created in the blood.
Take phtivazide orally. Compared with isoniazid, it is better tolerated and can be prescribed for poor tolerance of isoniazid.
The average daily dose for an adult is 1, 0 - 1, 5 g (0.5 g 2 - 3 times a day); for children at the rate of 0.02 - 0.03 - 0.04 g / kg (20 - 30 - 40 mg / kg) - not more than 1.5 g per day 3 times a day.
With ordinary (tuberculous) lupus, 0.25-0.3 g is prescribed 3-4 times a day for a course of 40-60 g. To achieve clinical cure, such courses are repeated 2 to 3 times with a monthly break.
Higher doses for adults inside: single 1 g, daily 2 g.
Possible side effects are similar to those observed with isoniazid. To prevent them, the use of pyridoxine is recommended (see Isoniazid).
Contraindications: angina pectoris and heart defects with decompensation, organic diseases of the central nervous system, kidney diseases of non-tuberculosis nature, accompanied by a violation of excretory function.
Method of production: powder, tablets of 0.1, 0.3 and 0.5 g in a package of 100 pieces.
Storage: List B. In a well-sealed container.