Description of the medicine: Florimycin sulfate (Florimycini sulfas)
FLORIMYCIN SULFATE (Florimycini sulfas).
Florimycin is an antibiotic that is a product of the vital activity of aromatic mushrooms Streptomyces floridae or other related organisms.
Synonyms: Viomycin, Florimycinum sulfuricum, Geliomycin, Vinactane, Viocin, Viomycinum sulfuricum, Vionactan.
Powder or porous mass of white or almost white, odorless, slightly bitter in taste. Easily soluble in water.
On chemotherapeutic properties it is close to kanamycin (see). It has a specific bacteriostatic effect on tuberculosis mycobacteria; also active against gram-positive and gram-negative bacteria.
It is a "reserve" drug in the treatment of various forms and localizations of tuberculosis. It is prescribed for patients whose first-line tuberculostatic drugs have been ineffective due to the development of resistance to them or for other reasons, as well as intolerance to other anti-tuberculosis drugs.
Apply intramuscularly (in the intestine it is not absorbed). Enter (slowly) deep into the upper outer quadrant of the buttock. Solutions for injection are prepared before use; 3 to 5 ml of sterile water for injection, isotonic sodium chloride solution or 0.25 - 0.5% novocaine solution is introduced into a vial containing 0.5-1.0 g (500,000-1,000,000 units) of the drug. The solution should be used during the first day.
The daily dose for adults is 1 g.
Enter daily at 0.5 g 2 times a day (morning and evening) or 1 g 1 time per day - for 6 consecutive days, on the 7th day a break. With prolonged treatment, sometimes they take a break for 2 days a week (in a row or after 2 to 3 days, one day).
The highest single dose for adults 1 g, daily 2 g. The dose for patients weighing less than 50 kg and people over 60 is 0.5 0.75 g per day.
In children, florimycin sulfate should be used with caution (due to difficulties in assessing the effect of the drug on hearing). Assign it to children suffering from chronic destructive tuberculosis, with the ineffectiveness of other drugs.
The daily dose for children is 0.015-0.02 g (15-20 mg / kg) (not more than 0.5 g for children and 0.75 g for adolescents).
It should be borne in mind that florimycin can have a toxic effect on the auditory nerve, so treatment should be carried out under the supervision of audiometry. At the first sign of hearing loss, the drug is canceled.
Florimycin can be combined with drugs of the I and II row (PASK, cycloserine, etc.). However, it cannot be combined with streptomycin and other antibiotics that have an ototoxic effect (neomycin, monomycin, kanamycin, etc.).
When applying florimycin, a headache, allergic dermatitis, protein in the urine may appear.
It should be borne in mind that in patients with impaired renal excretory function, the elimination of florimycin from the body is delayed, which can lead to an increase in its toxic effect.
The weakening of neurotoxic and allergic reactions can contribute to the use of calcium pantothenate. (See).
Contraindications: defeat of the VIII pair of cranial nerves and impaired renal function.