Medication Description: Florimycin Sulfate (Florimycini sulfas)
FLORIMYCIN SULFATE (Florimycini sulfas).
Florimitsin - an antibiotic that is a product of the vital activity of fragrant fungi Streptomyces floridae or other related organisms.
Synonyms: Viomitsin, Florimycinum sulfuricum, Geliomycin, Vinactane, Viocin, Viomycinum sulfuricum, Vionactan.
Powder or porous mass of white or almost white color, odorless, slightly bitter taste. Easily soluble in water.
Chemotherapeutic properties are close to kanamycin (see). It has a specific bacteriostatic effect on mycobacterium tuberculosis; is also active against gram-positive and gram-negative bacteria.
It is a "reserve" drug in the treatment of various forms and localizations of tuberculosis. It is prescribed to patients in whom tuberculostatic drugs of the first series have been ineffective due to the development of resistance to them or for other reasons, as well as intolerance to other anti-tuberculosis drugs.
Apply intramuscularly (in the intestine, it is not absorbed). Enter (slowly) deeply into the upper outer quadrant of the buttocks. Solutions for injections are prepared before use; in a bottle containing 0.5 - 1, 0 g (500 000 - 1 000 000 IU) of the drug, enter 3 - 5 ml of sterile water for injection, isotonic sodium chloride solution or 0.25 - 0.5% novocaine solution. The solution should be used within the first 24 hours.
The daily dose for adults is 1 g.
Entered daily at 0.5 g 2 times a day (morning and evening) or 1 g 1 time per day - for 6 consecutive days, on the 7th day break. With long-term treatment, sometimes they take a break for 2 days a week (in a row or after 2 to 3 days, one day each).
The highest single dose for explosive 1 g, daily 2 g. The dose for patients with a body weight below 50 kg and for persons over 60 years old is 0.5 0.75 g per day.
In children, phlorimycin sulfate should be used with caution (due to the difficulty of assessing the effect of the drug on hearing). Assign it to children suffering from chronic destructive tuberculosis, with the ineffectiveness of other means.
Daily dose for children is 0.015–0.02 g (15–20 mg / kg) (not more than 0.5 g for children and 0.75 g for adolescents).
It should be borne in mind that florimitsin may have a toxic effect on the auditory nerve, so treatment should be carried out under the control of audiometry. At the first sign of hearing loss, the drug is canceled.
Florimycin can be combined with drugs I and II series (PASK, cycloserine, etc.). However, it cannot be combined with streptomycin and other antibiotics, which have an ototoxic effect (neomycin, monomitsin, kanamycin, etc.).
When using florimitsin can cause headache, allergic dermatitis, protein in the urine.
It must be borne in mind that in patients with impaired renal excretory function, flimimycin elimination from the body is delayed, which can lead to an increase in its toxic action.
The use of calcium pantothenate may contribute to the weakening of neurotoxic and allergic reactions (see).
Contraindications: defeat of the eighth pair of cranial nerves and impaired renal function.