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Description of medicine: Akrikhin (Acrichinum)

AKRIKHIN (Acrichinum). 2-Methoxy-6-chloro-9- (1-methyl-1-diethylaminobutylamino) acridine dihydrochloride.

Synonyms: Atabrine, Atebrin, Chemiochin, Chinacrine, Haffkinine, Hepacrin, Italcihne, Malaricida, Mecaprine, Mepacrine hydrochloride, Mepacrini hydrochloridum, Mepacrinum, Methochin, Methoquine, Palacrin, Palusan, Pentilen Tenrin, Quin.

Yellow crystalline powder, bitter in taste. Soluble in water (at + 20 ° C to 3%; solubility increases when the solution is heated). Diluted aqueous solutions fluoresce. Aqueous solutions for injection are prepared aseptically.

Akrikhin is rapidly absorbed from the gastrointestinal tract; after taking a therapeutic dose, the maximum concentration in the blood is noted after 2 to 3 hours; a high level of the drug in the blood is held for several hours. Akrikhin is retained in the body for a long time. It is excreted mainly by the kidneys, partially excreted by bile, while in the duodenum it can be reabsorbed. Part of the drug taken is destroyed in the body.

By the nature of the antimalarial effect, Akrikhin is close to chingamine (chloroquine). Due to the fact that acrychin is less active and, in addition, causes staining of the skin and mucous membranes, it is currently practically not used as an antimalarial.

Akrikhin is also used as an anthelmintic and for the treatment of lupus erythematosus, cutaneous leishmaniasis, psoriasis.

As an antimalarial drug, Acrychin is taken orally after a meal, washed down with plenty of water. 1, 5 g is prescribed for the course: on the 1st day, 0.3 g 2 times with an interval of 6 hours, in 2 - 3 - 4 days - 0.3 g in - 1 dose. On the 1st day of treatment, you can give 0.3 g, in this case, the course of treatment is extended by 1 day. In severe cases of the disease, treatment can last up to 7 days.

Age-related daily doses of acrychin for children are the same as for bigumal.

As an anthelmintic, Akrikhin is used for cestodoses: invasions by bovine tapeworm (teniidosis), dwarf tapeworm (hymenolepidosis), broad tapeworm (diphyllobothriasis). On the eve and on the day of treatment, pureed food is taken with a restriction of fats, spicy and salty foods. At night, a saline laxative is prescribed. In the morning they put a cleansing enema and give on an empty stomach the entire prescribed dose of acrychin (take 1-2 tablets every 5-10 minutes, drink water with the addition of sodium bicarbonate).

Prescribe Akrikhin in the following doses: adults - 0.8 g; children 3 4 years old - 0.15 - 0.2 g, 5 - 6 years old - 0.25 - 0.3 g, 7 - 9 years old - 0.35 - 0.4 g, 10 - 12 years old - 0.45 - 0.5 g; 13-14 years old - 0.6 g; 15-16 years old - 0.7 g.

1/2 to 1 hour after taking the last pill, they give a saline laxative or complex senna infusion. Breakfast is allowed 1 to 2 hours after taking a laxative. If within 3 hours after taking the laxative there was no stool, an enema is given (adults out of 5 glasses of warm water, children less, respectively). If the parasites left without a head, put another 1 - 2 enemas.

With teniidosis and diphyllobothriasis, treatment is carried out once; with hymenolepidosis - 4 cycles of 3 days with an interval of 7 days. The drug is prescribed for adults at 0.3 g (in 2 divided doses after 20 minutes) per day on an empty stomach; on the 1st day of the first cycle after 2 hours they give a saline laxative.