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Medication Description: Akrikhin (Acrichinum)

AKRIKHIN (Acrichinum). 2-Methoxy-6-chloro-9- (1-methyl-1-diethylaminobutylamino) -acridine dihydrochloride.

Synonyms: Atabrine, Atebrin, Chemiochin, Chinacrine , Haffkinine, Hepacrin, Italcihne, Malaricida, Mecaprine, Mepacrine hydrochloride, Mepacrini hydrochloridum, Mepacrinum, Methochin, Methoquine, Palacrin, Palusan, Pentilen, Quinacrine, Tenicridine.

Yellow crystalline powder, bitter taste. Soluble in water (at + 20 'C to 3%; solubility increases when the solution is heated). Diluted aqueous solutions fluoresce. Aqueous solutions for injection are prepared aseptically.

Akrikhin is rapidly absorbed from the gastrointestinal tract; after taking a therapeutic dose, the maximum concentration in the blood is noted after 2 to 3 hours; a high level of the drug in the blood is retained for several hours. Akrikhin is long delayed in the body. Excreted mainly by the kidneys, partially excreted by the bile, while in the duodenum can be again absorbed. Part of the drug taken is destroyed in the body.

By the nature of the antimalarial effect, Akrihin is close to hingamin (chloroquine). Due to the fact that Akrikhin is less active and, in addition, causes staining of the skin and mucous membranes, it is now practically not used as an antimalarial agent.

Akrikhin is also used as an antihelminthic and for the treatment of lupus erythematosus, cutaneous leishmaniasis, psoriasis.

As an antimalarial drug, take Akrikhin inside after eating, drinking plenty of water. 1, 5 g is prescribed for the course: on the 1st day, 0.3 g 2 times with an interval of 6 hours, in 2–3 - 4th day — 0.3 g in 1 reception. On the 1st day of treatment, 0.3 g can be given, in this case, the course of treatment is extended by 1 day. In severe cases, the treatment can last up to 7 days.

Age-related daily doses for children are the same as for biguma.

As an antihelminthic, Akrikhin is used for cestodoses: bovine chain invasions (taeniasis), dwarf chains (hymenolepiasis), wide tapeworm (diphyllobotriosis). On the eve and on the day of treatment, they take pureed food with the restriction of fats, spicy and salty foods. At night, appoint saline laxative. In the morning, they put on a cleansing enema and give an empty stomach the entire prescribed dose of Akrikhin (take 1 to 2 tablets every 5 to 10 minutes, wash down with water and add sodium bicarbonate).

Appoint Akrikhin in the following doses: adults - 0.8 g; children 3 4 years old - 0.15 - 0.2 g, 5 - 6 years old - 0.25 - 0.3 g, 7 - 9 years old - 0.35 - 0.4 g, 10 - 12 years old - 0.45 - 0.5 g; 13 - 14 years old - 0.6 g, 15 - 16 years old - 0.7 g.

After 1/2 - 1 h after taking the last pill give a saline laxative or senna infusion complex. Breakfast is allowed 1 to 2 hours after taking a laxative. If there was no stool for 3 hours after taking the laxative, they give an enema (adults of 5 glasses of warm water, children, respectively, less). If the parasites come out without a head, put another 1 - 2 enemas.

In case of teniosis and diphyllobothriasis, treatment is carried out once; with hymenolepiasis - 4 cycles of 3 days with an interval of 7 days. The drug is prescribed to adults for 0.3 g (in 2 doses in 20 minutes) per day on an empty stomach; on the 1st day of the first cycle, after 2 hours, give a saline laxative.