Description of the medicine: Chinocidum
CHINOCID (Chinocidum). 6-Methoxy-8- (4-aminopentyl) aminoquinoline dihydrochloride.
Synonyms: Quinocide, Quinocidum.
Bitter orange-yellow crystalline powder. It is very easily soluble in water (1: 2), difficult - in alcohol.
The drug acts on paraerythrocytic forms of the malaria parasite, which cause long-term relapses.
They are used to prevent not only long-term relapses of three-four-day malaria, but also manifestations of these forms of malaria after the termination of personal chemoprophylaxis with a high risk of infection. The drug has a gamotropic effect on the sexual forms of all types of plasmodia.
In tropical malaria, chinocide can be prescribed after the end of treatment with hingamine (or other drugs that do not affect the P. falciparum gamont) to prevent the spread of malaria through the mosquito.
The dose per treatment course for adults is 0.3 or 0.28 g.
At a course dose of 0.3 g, take 0.02 g per day for 10 consecutive days (Scheme 1); with a course dose of 0.28 g, 0.02 g per day for 14 days (Scheme 2).
Higher doses: for adults inside: single and daily 0.03 g.
Children are given chinocide for 10 or 14 days in the following doses:
A course of treatment
Age, in a daily dose, g years
10 days 14 days (pattern 1) (pattern 2)
Up to 1 0.0025 0.0015 1 - 2 0.005 0.0025: 3 - 4 0.0075 0.005 5 - 7 0.01 0.0075 8 - 12 0.015 0.01 13 - 15 0.02 0.015
Over 15 0,03 0,02
The drug is taken 1 to 2 times after a meal.
Treatment according to Scheme 2 is carried out in debilitated patients (preferably in a hospital).
When taking chinocide, side effects may occur: nausea, headache, cyanosis of the lips and the nail bed, in some cases - signs of irritation of the kidneys and bladder, drug fever; slight hemolysis, leukopenia, or leukocytosis are possible. Side effects disappear after discontinuation of the drug.
In persons with congenital insufficiency in the red blood cells of the enzyme glucose-6-phosphate dehydrogenase (genetic abnormality), there is an increased sensitivity to drugs of the chinocide group (see Primakhin) with the possible development of acute hemolysis.
Relative contraindications: diseases of the blood and organs of the blood, kidney disease, angina pectoris. Chinocide can not be prescribed simultaneously with other antimalarial drugs, as this increases its toxicity.
Care must be taken when prescribing the drug to the elderly and debilitated patients.
Release form: coated tablets (Tabulettae Chinocidi obductae), at 0.005 and 0.01 g.
Storage: List B. In well-corked dark glass jars.