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Medication Description: Securininum (Securininum)

SEQUIRININ (Securininum).

The alkaloid securinine (C 13 H 15 O 2 N) is isolated from the herb of securinega semi-shrub, or branching [Securinega suffruticosa (Pall.), Seu ramiflora (Mull.-Arg.)], Herewith. euphorbia (Euphorbiaceae).

In medical practice, securinin nitrate (Securinini nitras, Securinine nitrate) is used.

Synonym: Securininum nitricum.

White or white with cream or pinkish tinge crystalline powder. Under the influence of light turns pink. Soluble in water, difficult to dissolve in alcohol.

It stimulates the central nervous system, increases the reflex excitability of the spinal cord, the nature of the action is close to strychnine. Compared with strychnine less active, but less toxic (8 - 10 times).

Applied with asthenic conditions, paresis and paralysis, which occurred after suffering infectious and other diseases, with hypo-and asthenic form of neurasthenia, with sexual impotence on the basis of functional nervous disorders, etc.

Assign inside (regardless of the meal) or under the skin. Inside take in the form of tablets of 0.002 g (2 mg), 2 times a day, or 0.4% solution of 10 - 12 drops, 2 times a day; A 0.2% solution of 1 ml (2 mg) is administered under the skin once a day. The drug is used daily for 20 to 30 days.

Higher doses for adults inside: single 0.005 g, 0.015 g daily; under the skin: single 0.003 g, daily 0.005 g

Possible side effects and contraindications are the same as with strychnine.

Method of production: tablets of 0.002 g (2 mg); 0.4% solution in vials of 20 ml (for oral administration); 0.2% solution in 1 ml ampoules (for subcutaneous injections).

Storage: List A. In a cool, dark place.

Rp .: Tab. Securinini nitratis 0,002

N. 20.

DS 1 tablet 2 times a day

Rp .: Sol. Securinini nitratis 0,4% 20 ml

DS On 1O drops 2 times a day

Rp .: Sol. Securinini nitratis 0,2% 1 ml

DtdN 20 in ampull.

S.