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Description of the medicine: Pentagastrin (Pentagastrinum)

PENTAGASTRIN (Pentagastrinum).

N-tert-butyloxycarbonyl-b-alanyl-L-tryptophil-L-methionyl-L-asparaginyl-L-phenylalanilamide (pentapeptide).

Synonyms: Acignost, Gastrodiagnost, Pentagastrin, Peptavlon.

Odorless amorphous powder, white or white with a slightly yellowish tint. Practically insoluble in water, very slightly soluble in alcohol.

It is a synthetic analogue of the hormone of the digestive tract - gastrin. It has the ability to strongly stimulate the secretion of the stomach. It is used as a stimulant of gastric secretion for the diagnosis of stomach diseases (for the definition of secretory ability and acid-forming function of the stomach, see also Histamine).

It is used as a 0.025% solution. 6 mcg (0.006 mg) per 1 kg of the patient’s body weight is injected under the skin.

After administration of the drug, secretion increases after 5-10 minutes, reaches a maximum after 15-30 minutes and lasts for 1 hour or more.

The study of gastric juice is usually carried out every 15 minutes for 1 hour or more.

With the introduction of the drug, salivation, nausea, a short-term moderate decrease in blood pressure, discomfort in the abdominal cavity are possible.

The use of pentagastrin is contraindicated in circulatory failure stage II - III, cardiac arrhythmias, severe hypotension.

Release form: in the form of a solution in ampoules containing 0.5 mg (2 ml = 500 μg of the drug).

Storage: List B. In the dark place at a temperature of +1 to +6 C.